MLKL Monoclonal Antibody

Uniprot : Q8NB16
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
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    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience

      Catalog number:E-AB-22249

      Synonyms:9130019I15Rik,FLJ34389,hMLKL,Mixed lineage kinase domain like,Mixed lineage kinase domain like protein,Mixed lineage kinase domain like pseudokinase,Mixed lineage kinase domain-like protein,Mlkl,MLKL

      Size:
      • 20μL
      • 60μL
      • 120μL
      • 200μL
      Qty:
      - +
      Price: $69

      Host: Mouse

      Reactivity: H

      Applications: IHC-p

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms 9130019I15Rik,FLJ34389,hMLKL,Mixed lineage kinase domain like,Mixed lineage kinase domain like protein,Mixed lineage kinase domain like pseudokinase,Mixed lineage kinase domain-like protein,Mlkl,MLKL
      Swissprot Q8NB16
      Source Mouse
      Reactivity Human
      Immunogen Synthetic Peptide of MLKL
      Application IHC-p(Detection kit: E-IR-R217)
      Recommended dilution IHC 1:100-200
      Concentration 1 mg/mL
      Clonality Monoclonal

      Properties

      Cellular localization Cytosol,Plasma Membrane,Other locations:cytoplasm
      Clone No. Clone:8H7
      Isotype IgG
      Purification Protein A purification
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
      Background This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene.MLKL (Mixed Lineage Kinase Domain Like Pseudokinase) is a Protein Coding gene. Among its related pathways are Apoptosis and Autophagy and CDK-mediated phosphorylation and removal of Cdc6. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity.

      Images

      monoclonal antibody-Elabscience

      Immunohistochemistry of paraffin-embedded Human tonsil tissue using MLKL Monoclonal Antibody at dilution of 1:200.

      monoclonal antibody-Elabscience

      Immunohistochemistry of paraffin-embedded Human skin tissue using MLKL Monoclonal Antibody at dilution of 1:200.

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