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Mouse IL-1β(Interleukin 1 Beta) ELISA Kit

Citations(442)Uniprot : P10749

Cat.No.:E-EL-M0037
Reactivity: Mouse

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96T
48T
24T
96T*5
96T*10

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Product Details

Properties

Assay type	Sandwich-ELISA
Format	96T/48T
Assay time	3.5h
Detection range	7.81-500 pg/mL
Sensitivity	4.69 pg/mL
Sample type &Sample volume	serum, plasma and other biological fluids; 100μL
Specificity	This kit recognizes Mouse IL-1β in samples. No significant cross-reactivity or interference between Mouse IL-1β and analogues was observed.
Reproducibility	Both intra-CV and inter-CV are < 10%.
Application	This ELISA kit applies to the in vitro quantitative determination of Mouse IL-1β concentrations in serum, plasma and other biological fluids.

Test Principle

This ELISA kit uses the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Mouse IL-1β. Standards or samples are added to the micro ELISA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for Mouse IL-1β and Avidin-Horseradish Peroxidase (HRP) conjugate are added successively to each micro plate well and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Mouse IL-1β, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of stop solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm ± 2 nm. The OD value is proportional to the concentration of Mouse IL-1β. You can calculate the concentration of Mouse IL-1β in the samples by comparing the OD of the samples to the standard curve.

Kit components & Storage

An unopened kit can be stored at 2-8℃ for 1 month. If the kit is not supposed to be used within 1 month, store the components separately according to the following conditions once the kit is received.

Item	Specifications	Storage
Micro ELISA Plate(Dismountable)	96T: 8 wells ×12 strips 48T: 8 wells ×6 strips	-20℃, 6 months
Reference Standard	96T: 2 vials 48T: 1 vial
Concentrated Biotinylated Detection Ab (100×)	96T: 1 vial, 120 μL 48T: 1 vial, 60 μL
Concentrated HRP Conjugate (100×)	96T: 1 vial, 120 μL 48T: 1 vial, 60 μL	-20℃(Protect from light), 6 months
Reference Standard & Sample Diluent	1 vial, 20 mL	2-8°C, 6 months
Biotinylated Detection Ab Diluent	1 vial, 14 mL
HRP Conjugate Diluent	1 vial, 14 mL
Concentrated Wash Buffer (25×)	1 vial, 30 mL
Substrate Reagent	1 vial, 10 mL	2-8℃(Protect from light)
Stop Solution	1 vial, 10 mL	2-8°C
Plate Sealer	5 pieces
Manual	1 copy
Certificate of Analysis	1 copy

Technical Data

Precision

Intra-assay Precision (Precision within an assay): 3 samples with low, mid range and high level Mouse IL-1β were tested 20 times on one plate, respectively.
Inter-assay Precision (Precision between assays): 3 samples with low, mid range and high level Mouse IL-1β were tested on 3 different plates, 20 replicates in each plate.

	Intra-assay Precision			Inter-assay Precision
Sample	1	2	3	1	2	3
n	20	20	20	20	20	20
Mean (pg/mL)	26.40	59.30	201.20	27.30	57.80	199.40
Standard deviation	1.70	3.20	10.10	1.80	2.40	8.80
CV (%)	6.44	5.40	5.02	6.59	4.15	4.41

Recovery

The recovery of Mouse IL-1β spiked at three different levels in samples throughout the range of the assay was evaluated in various matrices.

Sample Type	Range (%)	Average Recovery (%)
Serum(n=8)	88-103	96
EDTA plasma (n=8)	91-104	97
Cell culture media (n=8)	91-107	98

Linearity

Samples were spiked with high concentrations of Mouse IL-1β and diluted with Reference Standard & Sample Diluent to produce samples with values within the range of the assay.

Target Information

Database Links	SwissProt: P10749
Synonyms	IL1B, IL1-BETA, IL1F2, catabolin
Research Area	Cancer, Cardiovascular, Metabolism, Immunology

Assay Procedures

	1. Add 100μL standard or sample to the wells. Incubate for 90 min at 37°C
	2. Discard the liquid, immediately add 100μL Biotinylated Detection Ab working solution to each well. Incubate for 60 min at 37°C
	3. Aspirate and wash the plate for 3 times
	4. Add 100μL HRP conjugate working solution. Incubate for 30 min at 37°C. Aspirate and wash the plate for 5 times
	5. Add 90μL Substrate Reagent. Incubate for 15 min at 37°C
	6. Add 50μL Stop Solution
	7. Read the plate at 450nm immediately. Calculation of the results

Citations

BRAIN BEHAVIOR AND IMMUNITY (2022) IF: 19.227
Intestinal dysbiosis mediates cognitive impairment via the intestine and brain NLRP3 inflammasome activation in chronic sleep deprivation

DOI: 10.1016/j.bbi.2022.11.013

PMID: 36427810
Sample: serum
CHEMICAL ENGINEERING JOURNAL (2022) IF: 16.744
Tumor microenvironment activated nanoreactors for chemiluminescence imaging-guided simultaneous elimination of breast tumors and tumor-resident intracellular pathogens

DOI: 10.1016/j.cej.2022.139939

Sample: serum
BIOMATERIALS (2022) IF: 15.304
Blood-brain barrier Permeable nanoparticles for Alzheimer's disease treatment by selective mitophagy of microglia

DOI: 10.1016/j.biomaterials.2022.121690

PMID: 35965114
Sample: Brain tissue
Arthritis & Rheumatology (2022) IF: 15.483
NLRP3 attenuates intraocular inflammation by inhibiting AIM2 mediated pyroptosis through the P-SIK1/SREBF1 pathway

DOI: 10.1002/art.42420

Sample: BMDMs
MOLECULAR CELL (2017) IF: 14.714
Celastrol-Induced Nur77 Interaction with TRAF2 Alleviates Inflammation by Promoting Mitochondrial Ubiquitination and Autophagy

DOI: 10.1016/j.molcel.2017.03.008

Sample: Serum
CHEMICAL ENGINEERING JOURNAL (2022) IF: 13.273
2D MoSe2@PVP nanosheets with multi-enzyme activity alleviate the acute pancreatitis via scavenging the reactive oxygen and nitrogen species

DOI: 10.1016/j.cej.2022.136792

Sample: serum
Bone Research (2019) IF: 13.567
Extracellular vesicles from human urine-derived stem cells prevent osteoporosis by transferring CTHRC1 and OPG

DOI: 10.1038/s41413-019-0056-9

Sample: serum
Bone Research (2019) IF: 13.567
Extracellular vesicles from human urine-derived stem cells prevent osteoporosis by transferring CTHRC1 and OPG

DOI: 10.1038/s41413-019-0056-9

Sample: serum
Bone Research (2018) IF: 12.354
Omentin-1 prevents inflammation-induced osteoporosis by downregulating the pro-inflammatory cytokines

DOI: 10.1038/s41413-018-0012-0

Sample: Serum
Engineering (2022) IF: 12.834
CPAL, as a New Mediator of Cardiomyocyte Metabolic Alterations and Pyroptosis, Regulates Myocardial Infarction Injury in Mice

DOI: 10.1016/j.eng.2022.08.012

Sample: serum
JOURNAL OF CONTROLLED RELEASE (2023) IF: 11.467
Brain-neuron targeted nanoparticles for peptide synergy therapy at dual-target of Alzheimer's disease

DOI: 10.1016/j.jconrel.2023.01.074

Sample: brain tissues
Redox Biology (2022) IF: 11.799
STING signaling sensing of DRP1-dependent mtDNA release in kupffer cells contributes to lipopolysaccharide-induced liver injury in mice

DOI: 10.1016/j.redox.2022.102367

PMID: 35724543
Sample: serum,Kupffer cell (KCs)
JOURNAL OF NANOBIOTECHNOLOGY (2021) IF: 10.435
Gold nanoparticles reduce inflammation in cerebral microvessels of mice with sepsis

DOI: 10.1186/s12951-021-00796-6

PMID: 33608025
Sample: Tissue（brain）
SCIENCE OF THE TOTAL ENVIRONMENT (2023) IF: 10.753
The role of reactive astrocytes in neurotoxicity induced by ultrafine particulate matter

DOI: 10.1016/j.scitotenv.2023.161416

Sample: mixed glial cell
JOURNAL OF NANOBIOTECHNOLOGY (2023) IF: 9.429
Melanin-like polydopamine nanoparticles mediating anti-inflammatory and rescuing synaptic loss for inflammatory depression therapy

DOI: 10.1186/s12951-023-01807-4

Sample: serum
BRITISH JOURNAL OF PHARMACOLOGY (2022) IF: 9.4730
Repurposing nitazoxanide as a novel anti-atherosclerotic drug based on mitochondrial uncoupling mechanisms

DOI: 10.1111/bph.15949

PMID: 36082580
Sample: serum
BRITISH JOURNAL OF PHARMACOLOGY (2023) IF: 9.4730
Microsomal prostaglandin E synthase-1 inhibition prevents adverse cardiac remodeling after myocardial infarction in mice

DOI: 10.1111/bph.16061

Sample: Plasma
Molecular Neurodegeneration (2020) IF: 9.599
NLRP12 collaborates with NLRP3 and NLRC4 to promote pyroptosis inducing ganglion cell death of acute glaucoma

DOI: 10.1186/s13024-020-00372-w

Sample: BV2 cell
JOURNAL OF PATHOLOGY (2023) IF: 9.8829
MIF-inhibition alleviates vitiligo progression by suppressing CD8+T cell activation and proliferation

DOI: 10.1002/path.6073

Sample: serum
ENVIRONMENTAL POLLUTION (2022) IF: 9.988
Developmental exposure to chlorpyrifos causes neuroinflammation via necroptosis in mouse hippocampus and human microglial cell line

DOI: 10.1016/j.envpol.2022.120217

PMID: 36155221
Sample: hippocampi
ANALYTICAL CHEMISTRY (2022) IF: 8.0079
Visual Identification of Trichosporon asahii, a Gut Yeast Associated with Obesity, Using an Enzymatic NIR Fluorescent Probe

DOI: 10.1021/acs.analchem.2c01691

PMID: 35920602
Sample: hepatic tissue,epididymal fat tissue
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022) IF: 8.025
Structural characterization of a soluble polysaccharide SSPS1 from soy whey and its immunoregulatory activity in macrophages

DOI: 10.1016/j.ijbiomac.2022.07.043

PMID: 35835298
Sample: Raw 264.7 macrophages
Journal of Neuroinflammation (2021) IF: 8.3219
Sirtuin 3 protects against anesthesia/surgery-induced cognitive decline in aged mice by suppressing hippocampal neuroinflammation

DOI: 10.1186/s12974-021-02089-z

PMID: 33541361
Sample: Tissue homogenate(Hippocampal homogenate)
Journal of Neuroinflammation (2022) IF: 8.3219
Far infrared light irradiation enhances Aβ clearance via increased exocytotic microglial ATP and ameliorates cognitive deficit in Alzheimer’s disease-like mice

DOI: 10.1186/s12974-022-02521-y

Sample: brain
Cell Death & Disease (2022) IF: 8.4689
Pentraxin 3 regulated by miR-224-5p modulates macrophage reprogramming and exacerbates osteoarthritis associated synovitis by targeting CD32

DOI: 10.1038/s41419-022-04962-y

PMID: 35739102
Sample: RAW264.7 cell
Cell Death & Disease (2020) IF: 8.4689
MicroRNA-377-3p released by mesenchymal stem cell exosomes ameliorates lipopolysaccharide-induced acute lung injury by targeting RPTOR to induce autophagy

DOI: 10.1038/s41419-020-02857-4

Sample: BALF
Cellular and Molecular Gastroenterology and Hepatology (2022) IF: 8.7970
Klebsiella pneumoniae induces inflammatory bowel disease through caspase-11-mediated IL-18 in the gut epithelial cells

DOI: 10.1016/j.jcmgh.2022.11.005

Sample: colon tissue
CHEMOSPHERE (2020) IF: 7.086
Interleukin 17A deficiency alleviates fluoride-induced testicular injury by inhibiting the immune response and apoptosis

DOI: 10.1016/j.chemosphere.2020.128178

Sample: interstitial fluid
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2022) IF: 7.088
Discovery of novel hybrids containing clioquinol−1-benzyl-1,2,3,6-tetrahydropyridine as multi-target-directed ligands (MTDLs) against Alzheimer's disease

DOI: 10.1016/j.ejmech.2022.114841

Sample: cortex
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2023) IF: 7.129
Acute liver injury induced by carbon tetrachloride reversal by Gandankang aqueous extracts through nuclear factor erythroid 2-related factor 2 signaling pathway

DOI: 10.1016/j.ecoenv.2023.114527

Sample: liver,serum
CARBOHYDRATE POLYMERS (2020) IF: 7.182
Chitosan oligosaccharides attenuate loperamide-induced constipation through regulation of gut microbiota in mice

DOI: 10.1016/j.carbpol.2020.117218

PMID: 33278982
Sample: Tissue homogenate
Oxidative Medicine and Cellular Longevity (2023) IF: 7.31
RRP Regulates Autophagy through the AMPK Pathway to Alleviate the Effect of Cell Senescence on Atherosclerosis

DOI: 10.1155/2023/9645789

Sample: serum
Oxidative Medicine and Cellular Longevity (2022) IF: 7.31
Inositol Alleviates Pulmonary Fibrosis by Promoting Autophagy via Inhibiting the HIF-1α-SLUG Axis in Acute Respiratory Distress Syndrome

DOI: 10.1155/2022/1030238

Sample: serum,Human pulmonary alveolar epithelial cells (H
Oxidative Medicine and Cellular Longevity (2022) IF: 7.31
Downregulation of SIRT3 Aggravates Lung Ischemia Reperfusion Injury by Increasing Mitochondrial Fission and Oxidative Stress through HIF-1α-Dependent Mechanisms

DOI: 10.1155/2022/9041914

Sample: left lung tissue,bronchoalveolar lavage fluid (BAL
FREE RADICAL BIOLOGY AND MEDICINE (2022) IF: 7.376
Inhibition of neuronal nitric oxide synthase protects against hippocampal neuronal injuries by increasing neuropeptide Y expression in temporal lobe epilepsy mice

DOI: 10.1016/j.freeradbiomed.2022.06.221

PMID: 35714846
Sample: hippocampal tissue
FREE RADICAL BIOLOGY AND MEDICINE (2021) IF: 7.376
ADAM10 suppresses demyelination and reduces seizure susceptibility in cuprizone-induced demyelination model

DOI: 10.1016/j.freeradbiomed.2021.05.001

PMID: 33965566
Sample: Tissue homogenate
BIOMEDICINE & PHARMACOTHERAPY (2022) IF: 7.419
Tubuloside B, isolated from Cistanche tubulosa, a promising agent against M1 macrophage activation via synergistically targeting Mob1 and ERK1/2

DOI: 10.1016/j.biopha.2022.113414

PMID: 36076538
Sample: serum
BIOMEDICINE & PHARMACOTHERAPY (2023) IF: 7.419
Phillygenin inhibited M1 macrophage polarization and reduced hepatic stellate cell activation by inhibiting macrophage exosomal miR-125b-5p

DOI: 10.1016/j.biopha.2023.114264

Sample: RAW264.7 cell
BIOMEDICINE & PHARMACOTHERAPY (2022) IF: 7.419
1-Deoxynojirimycin attenuates septic cardiomyopathy by regulating oxidative stress, apoptosis, and inflammation via the JAK2/STAT6 signaling pathway

DOI: 10.1016/j.biopha.2022.113648

PMID: 36108388
Sample: serum
FOOD CHEMISTRY (2021) IF: 7.514
Premna microphylla Turcz leaf pectin exhibited antioxidant and anti-inflammatory activities in LPS-stimulated RAW 264.7 macrophages

DOI: 10.1016/j.foodchem.2021.129164

PMID: 33550022
Sample: Cell culture medium
Frontiers in Immunology (2022) IF: 7.561
PHLDA1 Suppresses TLR4-Triggered Proinflammatory Cytokine Production by Interaction With Tollip

DOI: 10.3389/fimmu.2022.731500

Sample: RAW264.7 cell,Bone marrow-derived macrophages
Frontiers in Immunology (2021) IF: 7.561
IL-27 Mediates Pro-Inflammatory Effects via the ERK Signaling Pathway During Preterm Labor

DOI: 10.3389/fimmu.2021.709229

PMID: 34691022
Sample: serum
Frontiers in Immunology (2022) IF: 7.561
HA/CD44 Regulates the T Helper 1 Cells Differentiation by Activating Annexin A1/Akt/mTOR Signaling to Drive the Pathogenesis of EAP.

DOI: 10.3389/fimmu.2022.875412

Sample: serum
Journal of Materials Chemistry B (2022) IF: 7.571
Oxidized chondroitin sulfate eye drops ameliorate the prognosis of fungal keratitis with anti-inflammatory and antifungal effects

DOI: 10.1039/D2TB00114D

PMID: 36070420
Sample: corneas
Antioxidants (2022) IF: 7.675
Comprehensive Effect of Carbon Tetrachloride and Reversal of Gandankang Formula in Mice Liver: Involved in Oxidative Stress, Excessive Inflammation, and Intestinal Microflora

DOI: 10.3390/antiox11112234

Sample: liver,serum
SCIENCE OF THE TOTAL ENVIRONMENT (2022) IF: 7.963
Suppression of NADPH oxidase 4 inhibits PM2.5-induced cardiac fibrosis through ROS-P38 MAPK pathway

DOI: 10.1016/j.scitotenv.2022.155558

PMID: 35504386
Sample: lungs,serum,,hearts
AMERICAN JOURNAL OF CHINESE MEDICINE (2022) IF: 6.005
Sinapic Acid Alleviates Acute Pancreatitis in Association with Attenuation of Inflammation, Pyroptosis, and the AMPK/NF-κ B Signaling Pathway

DOI: 10.1142/S0192415X2250094X

Sample: serum
ANALYTICAL CHEMISTRY (2018) IF: 6.042
A Redox-Responsive Self-Assembled Nanoprobe for Photoacoustic Inflammation Imaging to Assess Atherosclerotic Plaque Vulnerability

DOI: 10.1021/acs.analchem.8b04912

PMID: 30497260
Sample: Cell culture supernatant
Frontiers in Cardiovascular Medicine (2022) IF: 6.05
Sodium-Glucose Co-transporter-2 Inhibitor of Dapagliflozin Attenuates Myocardial Ischemia/Reperfusion Injury by Limiting NLRP3 Inflammasome Activation and Modulating Autophagy

DOI: 10.3389/fcvm.2021.768214

PMID: 35083298
Sample: serum
Frontiers in Cardiovascular Medicine (2021) IF: 6.05
Long Non-coding RNA N1LR Protects Against Myocardial Ischemic/Reperfusion Injury Through Regulating the TGF-β Signaling Pathway

DOI: 10.3389/fcvm.2021.654969

PMID: 34485393
Sample: serum
Neural Regeneration Research (2022) IF: 6.058
Sphingosine 1-phosphate receptor 1 regulates bloodbrain barrier permeability in epileptic mice

DOI: 10.4103/1673-5374.360263

Sample: hippocampal tissue
BIOCHEMICAL PHARMACOLOGY (2023) IF: 6.1
Inhibition of circular RNA ASPH reduces the proliferation and promotes the apoptosis of hepatic stellate cells in hepatic fibrosis

DOI: 10.1016/j.bcp.2023.115451

Sample: serum
ACTA PHARMACOLOGICA SINICA (2021) IF: 6.15
Luteolin alleviates cognitive impairment in Alzheimer’s disease mouse model via inhibiting endoplasmic reticulum stress-dependent neuroinflammation

DOI: 10.1038/s41401-021-00702-8

Sample: brain
FREE RADICAL BIOLOGY AND MEDICINE (2020) IF: 6.17
Dry eye induced by exposure to cigarette smoke pollution: An in vivo and in vitro study

DOI: 10.1016/j.freeradbiomed.2020.04.007

PMID: 32320747
Sample: Cell lysate,Cell culture supernatant
JOURNAL OF MEDICINAL CHEMISTRY (2020) IF: 6.205
Small-Molecule Antagonist Targeting Exportin-1 via Rational Structure-Based Discovery

DOI: 10.1021/acs.jmedchem.9b01663

Sample: serum
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022) IF: 6.208
Nanoparticle Emulsions Enhance the Inhibition of NLRP3

DOI: 10.3390/ijms231710168

PMID: 36077562
Sample: RAW 264.7 cell
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022) IF: 6.208
Inhibition of Netosis with PAD Inhibitor Attenuates Endotoxin Shock Induced Systemic Inflammation

DOI: 10.3390/ijms232113264

PMID: 36362052
Sample: serum
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2020) IF: 6.291
Silica particles disorganize the polarization of pulmonary macrophages in mice

DOI: 10.1016/j.ecoenv.2020.110364

PMID: 32114243
Sample: Tissue homogenate
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2021) IF: 6.291
Novel insights into the role of BRD4 in fine particulate matter induced airway hyperresponsiveness

DOI: 10.1016/j.ecoenv.2021.112440

PMID: 34175826
Sample: Bronchoalveolar lavage fluid
Cell Death & Disease (2020) IF: 6.304
GDF11 inhibits cardiomyocyte pyroptosis and exerts cardioprotection in acute myocardial infarction mice by upregulation of transcription factor HOXA3

DOI: 10.1038/s41419-020-03120-6

PMID: 33100331
Sample: Serum
Antioxidants (2022) IF: 6.313
Therapeutic Potential of Perillaldehyde in Ameliorating Vulvovaginal Candidiasis by Reducing Vaginal Oxidative Stress and Apoptosis

DOI: 10.3390/antiox11020178

PMID: 35204061
Sample: vaginal tissue
Food & Function (2023) IF: 6.317
DHA-enriched phosphatidylserine alleviates high fat diet-induced jejunum injury in mice by modulating gut microbiota

DOI: 10.1039/D2FO03019E

Sample: serum
Food & Function (2022) IF: 6.317
DHA-enriched phosphatidylcholine from Clupea harengus roes regulates the gut–liver axis to ameliorate high-fat diet-induced non-alcoholic fatty liver disease

DOI: 10.1039/D2FO02672D

Sample: liver
Journal of Materials Chemistry B (2021) IF: 6.331
The role of micro-vibration parameters in inflammatory responses of macrophages cultured on biphasic calcium phosphate ceramics and the resultant influence on osteogenic differentiation of mesenchymal stem cells

DOI: 10.1039/D1TB00898F

PMID: 34476430
Sample: RAW 264.7 cell
JOURNAL OF CELLULAR PHYSIOLOGY (2021) IF: 6.384
STING-mediated inflammation contributes to Gao binge ethanol feeding model

DOI: 10.1002/jcp.30606

PMID: 34698390
Sample: RAW264.7 cell
International Journal of Nanomedicine (2022) IF: 6.4
Pseudoephedrine Nanoparticles Alleviate Adriamycin-Induced Reproductive Toxicity Through the GnRhR Signaling Pathway

DOI: 10.2147/IJN.S348673

PMID: 35401001
Sample: testes
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021) IF: 6.514
Design and synthesis of 7-O-1,2,3-triazole hesperetin derivatives to relieve inflammation of acute liver injury in mice

DOI: 10.1016/j.ejmech.2021.113162

PMID: 33493826
Sample: Cell culture supernatant
BIOMEDICINE & PHARMACOTHERAPY (2018) IF: 6.53
Jinxin oral liquid inhibits human respiratory syncytial virus-induced excessive inflammation associated with blockade of the NLRP3/ASC/Caspase-1 pathway

DOI: 10.1016/j.biopha.2018.04.174

Sample: Serum,Tissue homogenate
BIOMEDICINE & PHARMACOTHERAPY (2019) IF: 6.53
Inhibition of HDAC6 attenuates LPS-induced inflammation in macrophages by regulating oxidative stress and suppressing the TLR4-MAPK/NF-κB pathways

DOI: 10.1016/j.biopha.2019.109166

PMID: 31255993
Sample: Cell culture supernatant
BIOMEDICINE & PHARMACOTHERAPY (2022) IF: 6.53
Ephedra herb reduces adriamycin-induced testicular toxicity by upregulating the gonadotropin-releasing hormone signalling pathway

DOI: 10.1016/j.biopha.2022.113061

PMID: 35658231
Sample: serum
BIOMEDICINE & PHARMACOTHERAPY (2021) IF: 6.53
Curcumin modulates multiple cell death, matrix metalloproteinase activation and cardiac protein release in susceptible and resistant Plasmodium berghei-infected mice

DOI: 10.1016/j.biopha.2021.112454

PMID: 34894518
Sample: serum
BIOMEDICINE & PHARMACOTHERAPY (2022) IF: 6.53
Activation of α7nAChR preserves intestinal barrier integrity by enhancing the HO-1 / STAT3 signaling to inhibit NF-κB activation in mice

DOI: 10.1016/j.biopha.2022.112733

PMID: 36068769
Sample: Serum
Oxidative Medicine and Cellular Longevity (2021) IF: 6.543
Vitamin B12 Attenuates Acute Pancreatitis by Suppressing Oxidative Stress and Improving Mitochondria Dysfunction via CBS/SIRT1 Pathway

DOI: 10.1155/2021/7936316

PMID: 34925701
Sample: Primary acinar cell
Oxidative Medicine and Cellular Longevity (2022) IF: 6.543
Preventive Effect of Collagen Peptides from Acaudina molpadioides on Acute Kidney Injury through Attenuation of Oxidative Stress and Inflammation

DOI: 10.1155/2022/8186838

PMID: 35592533
Sample: serum
SCIENCE OF THE TOTAL ENVIRONMENT (2020) IF: 6.551
Exposure to hyperandrogen drives ovarian dysfunction and fibrosis by activating the NLRP3 inflammasome in mice

DOI: 10.1016/j.scitotenv.2020.141049

Sample: serum
Frontiers in Nutrition (2022) IF: 6.576
Using Collagen Peptides From the Skin of Monkfish (Lophius litulon) to Ameliorate Kidney Damage in High-Fat Diet Fed Mice by Regulating the Nrf2 Pathway and NLRP3 Signaling

DOI: 10.3389/fnut.2022.798708

Sample: kidney
Frontiers in Nutrition (2022) IF: 6.59
The Protective Effect of Sulforaphane on Dextran Sulfate Sodium-Induced Colitis Depends on Gut Microbial and Nrf2-Related Mechanism

DOI: 10.3389/fnut.2022.893344

Sample: Serum
Cells (2019) IF: 6.6
Anti-Neuroinflammatory Effect of Alantolactone through the Suppression of the NF-κB and MAPK Signaling Pathways

DOI: 10.3390/cells8070739

Sample: BV2 cells
Cells (2019) IF: 6.6
Anti-Neuroinflammatory Effect of Alantolactone through the Suppression of the NF-κB and MAPK Signaling Pathways

DOI: 10.3390/cells8070739

Sample: BV2 cells
PHYTOMEDICINE (2022) IF: 6.656
Treatment of ulcerative colitis with Wu-Mei-Wan by inhibiting intestinal inflammatory response and repairing damaged intestinal mucosa

DOI: 10.1016/j.phymed.2022.154362

PMID: 35947900
Sample: serum
PHYTOMEDICINE (2022) IF: 6.656
Shexiang Baoxin Pill attenuates myocardial ischemia/reperfusion injury by activating autophagy via modulating the ceRNA-Map3k8 pathway

DOI: 10.1016/j.phymed.2022.154336

PMID: 35849969
Sample: serum,primary cardiomyocytes
PHYTOMEDICINE (2022) IF: 6.656
Salvianolactone acid A isolated from Salvia miltiorrhiza ameliorates lipopolysaccharide-induced acute lung injury in mice by regulating PPAR-γ

DOI: 10.1016/j.phymed.2022.154386

PMID: 35985183
Sample: Bronchoalveolar lavage fluid (BALF)
Nutrients (2022) IF: 6.706
Cornuside Is a Potential Agent against Alzheimer’s Disease via Orchestration of Reactive Astrocytes

DOI: 10.3390/nu14153179

Sample: cerebral tissue,BV2 cell
LIFE SCIENCES (2022) IF: 6.78
7,8-Dihydroxyflavone alleviates Endoplasmic Reticulum Stress in cafeteria diet-induced metabolic syndrome

DOI: 10.1016/j.lfs.2022.120781

PMID: 35835252
Sample: serum
CELL BIOLOGY AND TOXICOLOGY (2023) IF: 6.819
Syringaresinol protects against diabetic nephropathy by inhibiting pyroptosis via NRF2-mediated antioxidant pathway

DOI: 10.1007/s10565-023-09790-0

Sample: serum,Primary renal tubular epithelial cells (RTEC
Journal of Inflammation Research (2021) IF: 6.922
Histone Deacetylase 6 Regulates the Activation of M1 Macrophages by the Glycolytic Pathway During Acute Liver Failure

DOI: 10.2147/JIR.S302391

Sample: liver,RAW264.7 cell
Journal of Inflammation Research (2022) IF: 6.922
CD73 Attenuates Alcohol-Induced Liver Injury and Inflammation via Blocking TLR4/MyD88/NF-κB Signaling Pathway

DOI: 10.2147/JIR.S341680

Sample: serum,RAW264.7 cell
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022) IF: 6.953
Structures and immunomodulatory activity of one galactose- and arabinose-rich polysaccharide from Sambucus adnata

DOI: 10.1016/j.ijbiomac.2022.03.132

PMID: 35346678
Sample: RAW264.7 cell
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021) IF: 6.953
Structural characterization and immunomodulatory activities of two polysaccharides from Rehmanniae Radix Praeparata

DOI: 10.1016/j.ijbiomac.2021.06.100

PMID: 34197855
Sample: RAW264.7 cells
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021) IF: 6.953
Nitraria tangutorum Bobr.-derived polysaccharides protect against LPS-induced lung injury

DOI: 10.1016/j.ijbiomac.2021.06.181

PMID: 34216671
Sample: lung
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022) IF: 6.953
A monomeric polysaccharide from Polygonatum sibiricum improves cognitive functions in a model of Alzheimer's disease by reshaping the gut microbiota

DOI: 10.1016/j.ijbiomac.2022.05.185

PMID: 35661666
Sample: intestines
LIFE SCIENCES (2020) IF: 5.037
Sevoflurane up-regulates microRNA-204 to ameliorate myocardial ischemia/reperfusion injury in mice by suppressing Cotl1

DOI: 10.1016/j.lfs.2020.118162

PMID: 32730836
Sample: Tissue homogenate
LIFE SCIENCES (2021) IF: 5.037
Pancreastatin induces hepatic steatosis in type 2 diabetes by impeding mitochondrial functioning

DOI: 10.1016/j.lfs.2021.119905

PMID: 34453940
Sample: serum
LIFE SCIENCES (2020) IF: 5.037
Fenugreek attenuates obesity-induced inflammation and improves insulin resistance through downregulation of iRhom2/TACE

DOI: 10.1016/j.lfs.2020.118222

PMID: 32768577
Sample: Serum
LIFE SCIENCES (2021) IF: 5.037
Demethylenetetrahydroberberine alleviates nonalcoholic fatty liver disease by inhibiting the NLRP3 inflammasome and oxidative stress in mice

DOI: 10.1016/j.lfs.2021.119778

PMID: 34192596
Sample: serum
CELL PROLIFERATION (2019) IF: 5.039
Inhibition of CREB‐mediated ZO‐1 and activation of NF‐κB‐induced IL‐6 by colonic epithelial MCT4 destroys intestinal barrier function

DOI: 10.1111/cpr.12673

Sample: serum
CELL PROLIFERATION (2019) IF: 5.039
Inhibition of CREB‐mediated ZO‐1 and activation of NF‐κB‐induced IL‐6 by colonic epithelial MCT4 destroys intestinal barrier function

DOI: 10.1111/cpr.12673

Sample: serum
JOURNAL OF MOLECULAR ENDOCRINOLOGY (2021) IF: 5.098
Synoviolin inhibits inflammatory cytokine secretion of Müller cells by reducing NLRP3

DOI: 10.1530/JME-21-0123

Sample: serum
Marine Drugs (2022) IF: 5.118
Monkfish Peptides Mitigate High Fat Diet-Induced Hepatic Steatosis in Mice

DOI: 10.3390/md20050312

PMID: 35621963
Sample: hepatic
Food Science and Human Wellness (2022) IF: 5.154
Selenium-enriched oolong tea (Camellia sinensis) extract exerts anti-inflammatory potential via targeting NF-κB and MAPK pathways in macrophages

DOI: 10.1016/j.fshw.2021.12.020

Sample: RAW264.7 cell
ARTHRITIS RESEARCH & THERAPY (2021) IF: 5.156
Fargesin ameliorates osteoarthritis via macrophage reprogramming by downregulating MAPK and NF-κB pathways

DOI: 10.1186/s13075-021-02512-z

PMID: 33990219
Sample: Serum,Cell culture supernatant
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2016) IF: 5.158
The TIR/BB-loop mimetic AS-1 attenuates mechanical stress-induced cardiac fibroblast activation and paracrine secretion via modulation of large tumor suppressor kinase 1

DOI: 10.1016/j.bbadis.2016.03.002

Sample: Cell culture supernatant
Oncotarget (2017) IF: 5.168
λ-Carrageenan improves the antitumor effect of dendritic cellbased vaccine

DOI: 10.18632/oncotarget.15610

Sample: Dendritic cell
Oncotarget (2017) IF: 5.168
Wu-tou decoction attenuates neuropathic pain via suppressing spinal astrocytic IL-1R1/TRAF6/JNK signaling

DOI: 10.18632/oncotarget.21638

Sample: Tissue homogenate
FASEB JOURNAL (2021) IF: 5.192
Emodin inhibits lipid accumulation and inflammation in adipose tissue of high-fat diet-fed mice by inducing M2 polarization of adipose tissue macrophages

DOI: 10.1096/fj.202100157RR

PMID: 34110631
Sample: serum,macrophage cells
JOURNAL OF ETHNOPHARMACOLOGY (2022) IF: 5.195
Tanreqing injection protects against bleomycin-induced pulmonary fibrosis via inhibiting STING-mediated endoplasmic reticulum stress signaling pathway

DOI: 10.1016/j.jep.2022.116071

Sample: serum
EUROPEAN JOURNAL OF PHARMACOLOGY (2022) IF: 5.195
Anesthetic sevoflurane simultaneously regulates autophagic flux and pyroptotic cell death-associated cellular inflammation in the hypoxic/re-oxygenated cardiomyocytes: Identification of sevoflurane as putative drug for the treatment of myocardial ischemia

DOI: 10.1016/j.ejphar.2022.175363

PMID: 36343694
Sample: serum,myocardial tissue
CLINICAL SCIENCE (2020) IF: 5.223
DNMT3b-mediated methylation of ZSWIM3 enhances inflammation in alcohol-induced liver injury via regulating TRAF2-mediated NF-κB pathway

DOI: 10.1042/CS20200031

Sample: RAW264.7 cell
Cell Death Discovery (2019) IF: 5.241
Celastrol attenuates ox-LDL-induced mesangial cell proliferation via suppressing NLRP3 inflammasome activation

DOI: 10.1038/s41420-019-0196-0

Sample: MCs cells
CNS Neuroscience & Therapeutics (2022) IF: 5.243
Inhibition of phosphodiesterase-4 in the spinal dorsal horn ameliorates neuropathic pain via cAMP-cytokine-Cx43 signaling in mice

DOI: 10.1111/cns.13807

Sample: spinal cord
NEUROPHARMACOLOGY (2022) IF: 5.251
PEA-OXA ameliorates allodynia, neuropsychiatric and adipose tissue remodeling induced by social isolation

DOI: 10.1016/j.neuropharm.2022.108978

PMID: 35157898
Sample: Mesenchymal stromal cells (MSCs)
BIOORGANIC CHEMISTRY (2022) IF: 5.275
Twelve novel sesquiterpenes with anti-inflammatory and cholesterol-lowering activities from burdock leaves

DOI: 10.1016/j.bioorg.2022.105940

PMID: 35749853
Sample: RAW264.7 cell
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2021) IF: 5.279
Probiotic Bacillus cereus Alleviates Dextran Sulfate Sodium-Induced Colitis in Mice through Improvement of the Intestinal Barrier Function, Anti-Inflammation, and Gut Microbiota Modulation

DOI: 10.1021/acs.jafc.1c03375

PMID: 34677958
Sample: colon tissue
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2022) IF: 5.279
Laminaria japonica Polysaccharide Suppresses Atherosclerosis via Regulating Autophagy-Mediated Macrophage Polarization

DOI: 10.1021/acs.jafc.1c07483

PMID: 35167294
Sample: aortic,Raw264.7 cell
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2022) IF: 5.279
Industrially Produced Rice Protein Ameliorates Dextran Sulfate Sodium-Induced Colitis via Protecting the Intestinal Barrier, Mitigating Oxidative Stress, and Regulating Gut Microbiota

DOI: 10.1021/acs.jafc.2c00585

Sample: Colon tissue
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2021) IF: 5.279
Algal Oil Rich in Docosahexaenoic Acid Alleviates Intestinal Inflammation Induced by Antibiotics Associated with the Modulation of the Gut Microbiome and Metabolome

DOI: 10.1021/acs.jafc.0c07323

PMID: 33900083
Sample: Tissue homogenate(colon)
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021) IF: 5.31
Verapamil inhibits early acute liver failure through suppressing the NLRP3 inflammasome pathway

DOI: 10.1111/jcmm.16357

PMID: 34031983
Sample: Tissue homogenate
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021) IF: 5.31
Pseudolaric acid B ameliorates synovial inflammation and vessel formation by stabilizing PPARγ to inhibit NF-κB signalling pathway

DOI: 10.1111/jcmm.16670

PMID: 34117708
Sample: Raw 264.7 cells
Food Bioscience (2023) IF: 5.318
A comparative study of fermented buffalo and camel milk with anti-inflammatory, ACE-inhibitory and anti-diabetic properties and release of bio active peptides with molecular interactions: In vitro, in silico and molecular study

DOI: 10.1016/j.fbio.2023.102373

Sample: RAW 264.7 cell
PHYTOMEDICINE (2022) IF: 5.34
Tetrahydrocurcumin improves lipopolysaccharide-induced myocardial dysfunction by inhibiting oxidative stress and inflammation via JNK/ERK signaling pathway regulation

DOI: 10.1016/j.phymed.2022.154283

PMID: 35779282
Sample: serum
PHYTOMEDICINE (2021) IF: 5.34
Bioactive constituents of Mosla chinensis-cv. Jiangxiangru ameliorate inflammation through MAPK signaling pathways and modify intestinal microbiota in DSS-induced colitis mice

DOI: 10.1016/j.phymed.2021.153804

PMID: 34735907
Sample: colon tissue
Food & Function (2022) IF: 5.396
Bioactivity-guided isolation of the major anthocyanin from Lycium ruthenicum Murr. fruit and its antioxidant activity and neuroprotective effects in vitro and in vivo

DOI: 10.1039/D1FO04095B

PMID: 35233585
Sample: hippocampus
Food & Function (2021) IF: 5.396
Bioactives and their metabolites from Tetrastigma hemsleyanum leaves ameliorate DSS-induced colitis via protecting intestinal barrier, mitigating oxidative stress and regulating gut microbiota

DOI: 10.1039/D1FO02588K

Sample: colon tissue
Chinese Medicine (2021) IF: 5.455
Full-length transcriptome analysis reveals the mechanism of acupuncture at PC6 improves cardiac function in myocardial ischemia model

DOI: 10.1186/s13020-021-00465-8

PMID: 34238326
Sample: serum
Chinese Medicine (2022) IF: 5.455
Anti-inflammatory effects of anemonin on acute ulcerative colitis via targeted regulation of protein kinase C-θ

DOI: 10.1186/s13020-022-00599-3

PMID: 35346284
Sample: colon tissues
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2017) IF: 5.476
A novel mechanism of diabetic vascular endothelial dysfunction: Hypoadiponectinemia-induced NLRP3 inflammasome activation

DOI: 10.1016/j.bbadis.2017.02.012

Sample: Serum,Cell culture supernatant
Foods (2022) IF: 5.561
Encapsulation of Functional Plant Oil by Spray Drying: Physicochemical Characterization and Enhanced Anti-Colitis Activity

DOI: 10.3390/foods11192993

PMID: 36230069
Sample: serum
MOLECULAR NEUROBIOLOGY (2022) IF: 5.59
Selective GSK3β Inhibition Mediates an Nrf2-Independent Anti-inflammatory Microglial Response

DOI: 10.1007/s12035-022-02923-2

PMID: 35739410
Sample: SIM-A9 cell
EUROPEAN JOURNAL OF NUTRITION (2021) IF: 5.619
Broccoli microgreens juice reduces body weight by enhancing insulin sensitivity and modulating gut microbiota in high-fat diet-induced C57BL/6J obese mice

DOI: 10.1007/s00394-021-02553-9

PMID: 33866422
Sample: Serum
FREE RADICAL BIOLOGY AND MEDICINE (2019) IF: 5.657
Oral administration of 3,3′-diselenodipropionic acid prevents thoracic radiation induced pneumonitis in mice by suppressing NF-kB/IL-17/G-CSF/neutrophil axis

DOI: 10.1016/j.freeradbiomed.2019.09.009

Sample: Bronchoalveolar Lavage Fluid,Tissue homogenate
MOLECULAR NEUROBIOLOGY (2022) IF: 5.682
LncRNA Tug1 Contributes Post-stroke NLRP3 Inflammasome-Dependent Pyroptosis via miR-145a-5p/Tlr4 Axis

DOI: 10.1007/s12035-022-03000-4

PMID: 35989413
Sample: serum,BV-2 cell
Aging-US (2021) IF: 5.682
Investigating the mechanisms of Modified Xiaoyaosan (tiaogan-liqi prescription) in suppressing the progression of atherosclerosis, by means of integrative pharmacology and experimental validation

DOI: 10.18632/aging.202832

PMID: 33839698
Sample: Plasma
Aging-US (2021) IF: 5.682
CHIP ameliorates cerebral ischemia-reperfusion injury by attenuating necroptosis and inflammation

DOI: 10.18632/aging.203774

PMID: 34905731
Sample: brain
Journal of Neuroinflammation (2019) IF: 5.7
Baicalin ameliorates neuroinflammation-induced depressive-like behavior through inhibition of toll-like receptor 4 expression via the PI3K/AKT/FoxO1 pathway

DOI: 10.1186/s12974-019-1474-8

Sample: hippocampus tissue,BV2 cells,primary microglia cel
INTERNATIONAL IMMUNOPHARMACOLOGY (2023) IF: 5.714
Sustained activation of NLRP3 inflammasome contributes to delayed wound healing in aged mice

DOI: 10.1016/j.intimp.2023.109828

Sample: serum
INTERNATIONAL IMMUNOPHARMACOLOGY (2022) IF: 5.714
Caspase-8 is involved in pyroptosis, necroptosis and the maturation and release of IL-1β in Aspergillus fumigatus keratitis

DOI: 10.1016/j.intimp.2022.109275

PMID: 36274488
Sample: RAW264.7 cells
INTERNATIONAL IMMUNOPHARMACOLOGY (2023) IF: 5.714
C1q/tumor necrosis factor-related protein-6 exerts protective effects on myocardial ischemia–reperfusion injury through the modulation of the Akt-GSK-3β-Nrf2 signaling cascade

DOI: 10.1016/j.intimp.2023.109678

Sample: cardiac muscle tissues,cardiomyocytes
Neurotherapeutics (2018) IF: 5.719
Spatial Training Ameliorates Long-Term Alzheimer’s Disease-Like Pathological Deficits by Reducing NLRP3 Inflammasomes in PR5 Mice

DOI: 10.1007/s13311-018-00698-w

Sample: Tissue homogenate
Nutrients (2022) IF: 5.719
Procyanidin B2 Attenuates Nicotine-Induced Hepatocyte Pyroptosis through a PPARγ-Dependent Mechanism

DOI: 10.3390/nu14091756

Sample: serums,hepatocytes
Nutrients (2022) IF: 5.719
Friedelin Alleviates the Pathogenesis of Collagenase-Induced Tendinopathy in Mice by Promoting the Selective Autophagic Degradation of p65

DOI: 10.3390/nu14081673

PMID: 35458235
Sample: serum,tenocytes
Nutrients (2022) IF: 5.719
Drug D, a Diosgenin Derive, Inhibits L-Arginine-Induced Acute Pancreatitis through Meditating GSDMD in the Endoplasmic Reticulum via the TXNIP/HIF-1α Pathway

DOI: 10.3390/nu14132591

Sample: pancreatic tissue
Nutrients (2022) IF: 5.719
A Lard and Soybean Oil Mixture Alleviates Low-Fat–High-Carbohydrate Diet-Induced Nonalcoholic Fatty Liver Disease in Mice

DOI: 10.3390/nu14030560

Sample: liver
Frontiers in Aging Neuroscience (2022) IF: 5.75
Salidroside Ameliorates Alzheimer's Disease by Targeting NLRP3 Inflammasome-Mediated Pyroptosis

DOI: 10.3389/fnagi.2021.809433

Sample: brain tissue,PC12 cell
Frontiers in Aging Neuroscience (2022) IF: 5.75
Agomelatine Prevents Amyloid Plaque Deposition, Tau Phosphorylation, and Neuroinflammation in APP/PS1 Mice

DOI: 10.3389/fnagi.2021.766410

Sample: hippocampus tissue
CELL PROLIFERATION (2020) IF: 5.753
TNF‐α/HMGB1 inflammation signalling pathway regulates pyroptosis during liver failure and acute kidney injury

DOI: 10.1111/cpr.12829

Sample: serum
Journal of Neuroinflammation (2020) IF: 5.793
Systemic exosomal miR-193b-3p delivery attenuates neuroinflammation in early brain injury after subarachnoid hemorrhage in mice

DOI: 10.1186/s12974-020-01745-0

Sample: brain
Frontiers in Pharmacology (2022) IF: 5.811
Wu-Mei-Wan Ameliorates Murine Ulcerative Colitis by Regulating Macrophage Polarization

DOI: 10.3389/fphar.2022.859167

PMID: 35387334
Sample: Serum
Frontiers in Pharmacology (2022) IF: 5.811
The Effect of Shionone on Sepsis-Induced Acute Lung Injury by the ECM1/STAT5/NF-κB Pathway

DOI: 10.3389/fphar.2021.764247

Sample: serum,RAW264.7 cell
Frontiers in Pharmacology (2021) IF: 5.811
Oroxylin a Attenuates Limb Ischemia by Promoting Angiogenesis via Modulation of Endothelial Cell Migration

DOI: 10.3389/fphar.2021.705617

PMID: 34413777
Sample: muscle，serum
Frontiers in Pharmacology (2022) IF: 5.811
Naringin Interferes Doxorubicin-Induced Myocardial Injury by Promoting the Expression of ECHS1

DOI: 10.3389/fphar.2022.859755

PMID: 35496302
Sample: heart tissue
Frontiers in Pharmacology (2021) IF: 5.811
Ethyl 2-Succinate-Anthraquinone Attenuates Inflammatory Response and Oxidative Stress via Regulating NLRP3 Signaling Pathway.

DOI: 10.3389/fphar.2021.719822

Sample: blood
Frontiers in Pharmacology (2022) IF: 5.811
Anti-Epileptic Effect of Crocin on Experimental Temporal Lobe Epilepsy in Mice

DOI: 10.3389/fphar.2022.757729

Sample: cortex,hippocampus
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2022) IF: 5.895
Rice Protein Peptides Alleviate Dextran Sulfate Sodium-Induced Colitis via the Keap1–Nrf2 Signaling Pathway and Regulating Gut Microbiota

DOI: 10.1021/acs.jafc.2c04862

Sample: colon tissue
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021) IF: 5.924
Terazosin Stimulates Pgk1 to Remedy Gastrointestinal Disorders

DOI: 10.3390/ijms23010416

PMID: 35008842
Sample: colon tissue
ANTIVIRAL RESEARCH (2019) IF: 5.97
N-Acetyl cysteine effectively alleviates Coxsackievirus B-Induced myocarditis through suppressing viral replication and inflammatory response

DOI: 10.1016/j.antiviral.2019.104699

Sample: heart
Frontiers in Pharmacology (2022) IF: 5.988
MiR-146b-5p/TRAF6 axis is essential for Ginkgo biloba L. extract GBE to attenuate LPS-induced neuroinflammation

DOI: 10.3389/fphar.2022.978587

PMID: 36091773
Sample: BV-2 cell
Frontiers in Pharmacology (2022) IF: 5.988
Metformin Alleviates LPS-Induced Acute Lung Injury by Regulating the SIRT1/NF-κB/NLRP3 Pathway and Inhibiting Endothelial Cell Pyroptosis

DOI: 10.3389/fphar.2022.801337

PMID: 35910360
Sample: lung tissue,Pulmonary ECs
Frontiers in Aging Neuroscience (2015) IF: 4
PGC-1 silencing compounds the perturbation of mitochondrial function caused by mutant SOD1 in skeletal muscle of ALS mouse model

DOI: 10.3389/fnagi.2015.00204

Sample: Serum
JOURNAL OF NATURAL PRODUCTS (2022) IF: 4.05
A Natural Plant Ingredient, Menthone, Regulates T Cell Subtypes and Lowers Pro-inflammatory Cytokines of Rheumatoid Arthritis

DOI: 10.1021/acs.jnatprod.1c01231

PMID: 35302365
Sample: blood
American Journal of Translational Research (2019) IF: 4.06
Xiaoyaosan prevents atherosclerotic vulnerable plaque formation through heat shock protein/glucocorticoid receptor axis-mediated mechanism

PMID: 31632527
Sample: serum
American Journal of Translational Research (2019) IF: 4.06
Vascular endothelial Cdc42 deficiency delays skin wound-healing processes by increasing IL-1β and TNF-α expression

PMID: 30787984
Sample: skin tissues
American Journal of Translational Research (2021) IF: 4.06
Upregulation of the P2X7 receptor promotes Ca2+ accumulation and inflammatory response in post-stroke depression

PMID: 34650696
Sample: serum
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY (2019) IF: 4.067
Ameliorative effects of snake (Deinagkistrodon acutus) oil and its main fatty acids against UVB-induced skin photodamage in mice

DOI: 10.1016/j.jphotobiol.2019.111538

Sample: skin
BRAIN RESEARCH BULLETIN (2021) IF: 4.079
Sesamin suppresses advanced glycation end products induced microglial reactivity using BV2 microglial cell line as a model

DOI: 10.1016/j.brainresbull.2021.04.012

PMID: 33894297
Sample: Cell culture medium
BIOLOGICAL TRACE ELEMENT RESEARCH (2022) IF: 4.081
Selenium Supplementation Protects Against Arsenic-Trioxide-Induced Cardiotoxicity Via Reducing Oxidative Stress and Inflammation Through Increasing NAD+ Pool

DOI: 10.1007/s12011-022-03478-y

Sample: heart tissue
Biomolecules (2020) IF: 4.082
Preparation, Characterization, and Immuno-Enhancing Activity of Polysaccharides from Glycyrrhiza uralensis

DOI: 10.3390/biom10010159

PMID: 31963790
Sample: Cell culture supernatant,Cell sample
Foods (2020) IF: 4.092
Protective Effect of Prunus mume Fermented with Mixed Lactic Acid Bacteria in Dextran Sodium Sulfate-Induced Colitis

DOI: 10.3390/foods10010058

PMID: 33383792
Sample: colon tissue,serum
INFLAMMATION (2021) IF: 4.092
Benzoylaconine Modulates LPS-Induced Responses Through Inhibition of Toll-Like Receptor-Mediated NF-κB and MAPK Signaling in RAW264.7 Cells

DOI: 10.1007/s10753-021-01478-z

Sample: RAW264.7 cells
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2022) IF: 4.101
Resveratrol ameliorates nutritional steatohepatitis through the mmu‑miR‑599/PXR pathway

DOI: 10.3892/ijmm.2022.5102

PMID: 35137921
Sample: serum
PROSTATE (2021) IF: 4.104
Melatonin attenuates prostatic inflammation and pelvic pain via Sirt1-dependent inhibition of the NLRP3 inflammasome in an EAP mouse model

DOI: 10.1002/pros.24214

PMID: 34418127
Sample: serum
ENVIRONMENTAL TOXICOLOGY (2022) IF: 4.119
Upregulation of FAM129B protects cardiomyocytes from hypoxia/reoxygenation-induced injury by inhibiting apoptosis, oxidative stress, and inflammatory response via enhancing Nrf2/ARE activation

DOI: 10.1002/tox.23461

PMID: 34995000
Sample: cardiomyocytes
ENVIRONMENTAL TOXICOLOGY (2021) IF: 4.119
Inhibition of USP15 ameliorates high-glucose-induced oxidative stress and inflammatory injury in podocytes through regulation of the Keap1/Nrf2 signaling

DOI: 10.1002/tox.23441

PMID: 34931430
Sample: MPC5 cell
ENVIRONMENTAL TOXICOLOGY (2021) IF: 4.119
Effects of 2,4-dichlorophenoxyacetic acid on the expression of NLRP3 inflammasome and autophagy-related proteins as well as the protective effect of Lycium barbarum polysaccharide in neonatal rats

DOI: 10.1002/tox.23358

PMID: 34464015
Sample: BV2 cell
ENVIRONMENTAL TOXICOLOGY (2022) IF: 4.119
2,4-dichlorophenoxyacetic acid induces ROS activation in NLRP3 inflammatory body-induced autophagy disorder in microglia and the protective effect of Lycium barbarum polysaccharide

DOI: 10.1002/tox.23471

PMID: 35099110
Sample: BV2 cell
Scientific Reports (2018) IF: 4.122
Ageratina adenophora induces mice hepatotoxicity via ROS-NLRP3-mediated pyroptosis

DOI: 10.1038/s41598-018-34492-7

PMID: 30375483
Sample: Serum,Tissue homogenate
Frontiers in Cellular and Infection Microbiology (2020) IF: 4.123
Extracellular Histone H3 Induces Pyroptosis During Sepsis and May Act Through NOD2 and VSIG4/NLRP3 Pathways

DOI: 10.3389/fcimb.2020.00196

PMID: 32432055
Sample: Cell culture supernatant
Drug Design Development and Therapy (2022) IF: 4.162
Didymin Ameliorates Liver Fibrosis by Alleviating Endoplasmic Reticulum Stress and Glycerophospholipid Metabolism: Based on Transcriptomics and Metabolomics

DOI: 10.2147/DDDT.S351092

PMID: 35698653
Sample: liver
Food & Function (2020) IF: 4.171
Melatonin as an inducer of arecoline and their coordinated roles in anti-oxidative activity and immune responses

DOI: 10.1039/D0FO01841D

PMID: 32955540
Sample: Plasma
Food & Function (2020) IF: 4.171
Flaxseed oligosaccharides alleviate DSS-induced colitis through modulation of gut microbiota and repair of the intestinal barrier in mice

DOI: 10.1039/D0FO01105C

PMID: 32856645
Sample: Serum,Tissue homogenate
Food & Function (2020) IF: 4.171
Akebia trifoliata pericarp extract ameliorates inflammation through NF-κB/MAPK signaling pathways and modifies gut microbiota

DOI: 10.1039/C9FO02917F

Sample: colon tissue
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019) IF: 4.183
Salidroside Ameliorates Renal Interstitial Fibrosis by Inhibiting the TLR4/NF-κB and MAPK Signaling Pathways

DOI: 10.3390/ijms20051103

PMID: 30836660
Sample: Serum
TOXICOLOGY (2021) IF: 4.221
O-alkyl and o-benzyl hesperetin derivative-1L attenuates inflammation and protects against alcoholic liver injury via inhibition of BRD2-NF-κB signaling pathway

DOI: 10.1016/j.tox.2021.153087

PMID: 34974135
Sample: serum,RAW264.7 cell
Frontiers in Microbiology (2020) IF: 4.236
Immunization With a Secreted Esterase Protects Mice Against Multiple Serotypes (M1, M3, and M28) of Group A Streptococcus

DOI: 10.3389/fmicb.2020.00565

Sample: skin
Frontiers in Microbiology (2020) IF: 4.236
Algal Oil Rich in n-3 PUFA Alleviates DSS-Induced Colitis via Regulation of Gut Microbiota and Restoration of Intestinal Barrier

DOI: 10.3389/fmicb.2020.615404

Sample: serum
Food Bioscience (2022) IF: 4.24
Exploring the potential of Lactobacillus and Saccharomyces for biofunctionalities and the release of bioactive peptides from whey protein fermentate

DOI: 10.1016/j.fbio.2022.101758

Sample: RAW264.7 cell
Food Bioscience (2021) IF: 4.24
Exploring potentials of antioxidative, anti-inflammatory activities and production of bioactive peptides in lactic fermented camel milk

DOI: 10.1016/j.fbio.2021.101404

Sample: RAW 264.7 cell
Food Bioscience (2022) IF: 4.24
Antioxidative, antimicrobial and anti-inflammatory activities and release of ultra-filtered antioxidative and antimicrobial peptides during fermentation of sheep milk: In-vitro, in-silico and molecular interaction studies

DOI: 10.1016/j.fbio.2022.101666

Sample: RAW 264.7 murine macrophage cell
Scientific Reports (2017) IF: 4.259
Glycyrrhiza uralensis water extract enhances dendritic cell maturation and antitumor efficacy of HPV dendritic cell-based vaccine

DOI: 10.1038/srep43796

Sample: Cell culture supernatant
INTERNATIONAL JOURNAL OF DAIRY TECHNOLOGY (2022) IF: 4.286
Identification and molecular mechanisms of novel antioxidative peptides from fermented camel milk (Kachchi breed, India) with anti-inflammatory activity in raw macrophages cell lines

DOI: 10.1111/1471-0307.12911

Sample: RAW 264.7 cells
INTERNATIONAL JOURNAL OF DAIRY TECHNOLOGY (2022) IF: 4.286
Antidiabetic, angiotensin-converting enzyme inhibitory and anti-inflammatory activities of fermented camel milk and characterisation of novel bioactive peptides from lactic-fermented camel milk with molecular interaction study

DOI: 10.1111/1471-0307.12910

Sample: RAW 264.7 cell
NEUROCHEMISTRY INTERNATIONAL (2022) IF: 4.297
Calcium channel antagonists interfere with the mechanism of action of elastin-derived peptide VGVAPG in mouse cortical astrocytes in vitro

DOI: 10.1016/j.neuint.2022.105405

PMID: 35934159
Sample: astrocyte cell
Foods (2021) IF: 4.35
Green Pea (Pisum sativum L.) Hull Polyphenol Extracts Ameliorate DSS-Induced Colitis through Keap1/Nrf2 Pathway and Gut Microbiota Modulation

DOI: 10.3390/foods10112765

Sample: colon
DRUG DEVELOPMENT RESEARCH (2021) IF: 4.36
Tanshinol alleviates ulcerative colitis by promoting the expression of VLDLR

DOI: 10.1002/ddr.21840

PMID: 34145621
Sample: colon
NEUROPHARMACOLOGY (2019) IF: 4.367
Modulation of LPA1 receptor-mediated neuronal apoptosis by Saikosaponin-d: A target involved in depression

DOI: 10.1016/j.neuropharm.2019.05.027

Sample: hippocampus tissue
TOXICOLOGY LETTERS (2022) IF: 4.374
Adenosine receptor A2B mediates alcoholic hepatitis by regulating cAMP levels and the NF-KB pathway

DOI: 10.1016/j.toxlet.2022.01.012

PMID: 35143882
Sample: serum,RAW264.7 cell
Scientific Reports (2021) IF: 4.38
The protective effect of the PDE-4 inhibitor rolipram on intracerebral haemorrhage is associated with the cAMP/AMPK/SIRT1 pathway

DOI: 10.1038/s41598-021-98743-w

PMID: 34611179
Sample: Brain tissue
Scientific Reports (2021) IF: 4.38
Studies on the mitochondrial, immunological and inflammatory effects of solvent fractions of Diospyros mespiliformis Hochst in Plasmodium berghei-infected mice

DOI: 10.1038/s41598-021-85790-6

PMID: 33767260
Sample: Serum
Scientific Reports (2021) IF: 4.38
Hepatoprotective effect of Thymus vulgaris extract on sodium nitrite-induced changes in oxidative stress, antioxidant and inflammatory marker expression

DOI: 10.1038/s41598-021-85264-9

PMID: 33707592
Sample: Serum
MOLECULAR IMMUNOLOGY (2022) IF: 4.407
The therapeutic potential of chondroitin sulfate in Aspergillus fumigatus keratitis

DOI: 10.1016/j.molimm.2022.04.007

PMID: 35504058
Sample: corneas,RAW 264.7 cell
MOLECULES (2022) IF: 4.412
The Expression and Bioinformatics Analysis of Circular RNAs in Endometritis Mouse Uterus Tissues

DOI: 10.3390/molecules27123682

PMID: 35744807
Sample: uterine tissue
MOLECULES (2022) IF: 4.412
Eriodictyol and Homoeriodictyol Improve Memory Impairment in Aβ25–35-Induced Mice by Inhibiting the NLRP3 Inflammasome

DOI: 10.3390/molecules27082488

Sample: brain
JOURNAL OF NUTRITION (2019) IF: 4.416
Lactobacillus acidophilus Exerts Neuroprotective Effects in Mice with Traumatic Brain Injury

DOI: 10.1093/jn/nxz105

PMID: 31174208
Sample: Serum,Tissue homogenate
ACS Chemical Neuroscience (2021) IF: 4.418
Peripheral Administration of a Cell-Penetrating MOTS-c Analogue Enhances Memory and Attenuates Aβ1–42- or LPS-Induced Memory Impairment through Inhibiting Neuroinflammation

DOI: 10.1021/acschemneuro.0c00782

Sample: Tissue homogenate(hippocampus)
NEUROPHARMACOLOGY (2020) IF: 4.431
Seizure-induced neuroinflammation contributes to ectopic neurogenesis and aggressive behavior in pilocarpine-induced status epilepticus mice

DOI: 10.1016/j.neuropharm.2020.108044

PMID: 32179291
Sample: Cell lysate
EUROPEAN JOURNAL OF PHARMACOLOGY (2022) IF: 4.432
Research on the effect and underlying molecular mechanism of Cangzhu in the treatment of gouty arthritis

DOI: 10.1016/j.ejphar.2022.175044

Sample: RAW264.7-cell
EUROPEAN JOURNAL OF PHARMACOLOGY (2021) IF: 4.432
Phillygenin inhibited LPS-induced RAW 264.7 cell inflammation by NF-κB pathway

DOI: 10.1016/j.ejphar.2021.174043

Sample: Cell culture supernatant
EUROPEAN JOURNAL OF PHARMACOLOGY (2022) IF: 4.432
Laccase-mediated functionalization of natamycin by gallic acids for the therapeutic effect on Aspergillus fumigatus keratitis

DOI: 10.1016/j.ejphar.2022.175041

PMID: 35597265
Sample: corneas,RAW264.7 cell
EUROPEAN JOURNAL OF PHARMACOLOGY (2022) IF: 4.432
Intervention of 3-aminobenzamide against Dextran Sulphate Sodium induced colitis in mice: Investigations on molecular mechanisms

DOI: 10.1016/j.ejphar.2022.174861

PMID: 35219730
Sample: Colon
Journal of Functional Foods (2021) IF: 4.451
Structural characterization and immunomodulatory activity of a glucan from Radix Codonopsis

DOI: 10.1016/j.jff.2021.104537

Sample: Cell culture supernatant
Journal of Functional Foods (2022) IF: 4.451
Antioxidative mechanisms and anticolitic potential of Desmodium styracifolium (Osb.) Merr. in DSS-induced colitic mice

DOI: 10.1016/j.jff.2022.105077

Sample: colonic tissue
TOXICOLOGY AND APPLIED PHARMACOLOGY (2023) IF: 4.46
Dihydrokaempferol attenuates CCl4-induced hepatic fibrosis by inhibiting PARP-1 to affect multiple downstream pathways and cytokines

DOI: 10.1016/j.taap.2023.116438

Sample: serum
INFLAMMOPHARMACOLOGY (2021) IF: 4.473
Terpene-rich fractions of Ficus mucoso (Welw) modulate lipopolysaccharide-induced inflammatory mediators and aberrant permeability of the inner mitochondrial membrane in murine animal model

DOI: 10.1007/s10787-021-00876-x

PMID: 34613566
Sample: serum
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020) IF: 4.486
Polysaccharides from Dicliptera chinensis ameliorate liver disturbance by regulating TLR‐4/NF‐κB and AMPK/Nrf2 signalling pathways

DOI: 10.1111/jcmm.15286

Sample: Serum,Tissue homogenate
ACS Chemical Neuroscience (2020) IF: 4.486
MG53 Protects hUC-MSCs against Inflammatory Damage and Synergistically Enhances Their Efficacy in Neuroinflammation Injured Brain through Inhibiting NLRP3/Caspase-1/IL-1β Axis

DOI: 10.1021/acschemneuro.0c00268

PMID: 32786312
Sample: Serum
ACS Chemical Neuroscience (2020) IF: 4.486
Autophagy Activation Represses Pyroptosis through the IL-13 and JAK1/STAT1 Pathways in a Mouse Model of Moderate Traumatic Brain Injury

DOI: 10.1021/acschemneuro.0c00517

PMID: 33170612
Sample: Plasma
MEDIATORS OF INFLAMMATION (2023) IF: 4.529
Integrative Analysis of Transcriptome and Metabolome to Illuminate the Protective Effects of Didymin against Acute Hepatic Injury

DOI: 10.1155/2023/6051946

Sample: Serum
BIOMEDICINE & PHARMACOTHERAPY (2020) IF: 4.545
Study on the protective effect and mechanism of Dicliptera chinensis (L.) Juss (Acanthaceae) polysaccharide on immune liver injury induced by LPS

DOI: 10.1016/j.biopha.2020.111159

PMID: 33370627
Sample: Tissue homogenate
INFLAMMATION (2022) IF: 4.657
Anti-inflammatory Effect of a Limonin Derivative In Vivo and Its Mechanisms in RAW264.7 Cells

DOI: 10.1007/s10753-022-01722-0

PMID: 35986873
Sample: Raw 264.7 cell
Frontiers in Immunology (2019) IF: 4.716
Intranasal MMI-0100 Attenuates Aβ1−42- and LPS-Induced Neuroinflammation and Memory Impairments via the MK2 Signaling Pathway

DOI: 10.3389/fimmu.2019.02707

Sample: Tissue homogenate
NEUROMODULATION (2022) IF: 4.722
Electroacupuncture Ameliorates Intestinal Barrier Destruction in Mice With Bile Duct Ligation–Induced Liver Injury by Activating the Cholinergic Anti-Inflammatory Pathway

DOI: 10.1016/j.neurom.2022.02.001

Sample: plasma
JOURNAL OF PSYCHIATRIC RESEARCH (2021) IF: 4.791
Lipopolysaccharide exacerbates chronic restraint stress-induced neurobehavioral deficits: Mechanisms by redox imbalance, ASK1-related apoptosis, autophagic dysregulation

DOI: 10.1016/j.jpsychires.2021.10.021

PMID: 34768069
Sample: serum,brain
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2021) IF: 4.799
Isorhamnetin Ameliorates Aspergillus fumigatus Keratitis by Reducing Fungal Load, Inhibiting Pattern-Recognition Receptors and Inflammatory Cytokines

DOI: 10.1167/iovs.62.3.38

PMID: 33783487
Sample: Tissue homogenate(corneas)
Aging-US (2020) IF: 4.831
Salidroside ameliorates Parkinson's disease by inhibiting NLRP3-dependent pyroptosis

DOI: 10.18632/aging.103215

PMID: 32432571
Sample: Cell culture supernatant,Tissue homogenate
Aging-US (2020) IF: 4.831
Lipopolysaccharide upregulates miR-132/212 in Hirschsprung-associated enterocolitis, facilitating pyroptosis by activating NLRP3 inflammasome via targeting Sirtuin 1 (SIRT1)

DOI: 10.18632/aging.103852

PMID: 32950974
Sample: Serum
Oxidative Medicine and Cellular Longevity (2019) IF: 4.868
Reactive Oxygen Species Are Involved in the Development of Gastric Cancer and Gastric Cancer-Related Depression through ABL1-Mediated Inflammation Signaling Pathway

DOI: 10.1155/2019/5813985

Sample: blood
MOLECULES (2023) IF: 4.927
Neuroprotective Effects of Savinin on LPS-Induced Neuroinflammation In Vivo via Regulating MAPK/NF-κB Pathway and NLRP3 Inflammasome Activation

DOI: 10.3390/molecules28041575

Sample: Serum
MOLECULES (2022) IF: 4.927
Monkfish (Lophius litulon) Peptides Ameliorate High-Fat-Diet-Induced Nephrotoxicity by Reducing Oxidative Stress and Inflammation via Regulation of Intestinal Flora

DOI: 10.3390/molecules28010245

Sample: renal tissue
MOLECULES (2023) IF: 4.927
Design, Synthesis, and Anti-Inflammatory Activities of 12-Dehydropyxinol Derivatives

DOI: 10.3390/molecules28031307

Sample: RAW264.7 cell
INTERNATIONAL IMMUNOPHARMACOLOGY (2022) IF: 4.932
The selective STING inhibitor H-151 preserves myocardial function and ameliorates cardiac fibrosis in murine myocardial infarction

DOI: 10.1016/j.intimp.2022.108658

PMID: 35278833
Sample: serum
INTERNATIONAL IMMUNOPHARMACOLOGY (2021) IF: 4.932
Senescence marker protein 30 (SMP30) protects against high glucose-induced apoptosis, oxidative stress and inflammatory response in retinal ganglion cells by enhancing Nrf2 activation via regulation of Akt/GSK-3β pathway

DOI: 10.1016/j.intimp.2021.108238

PMID: 34688152
Sample: RGCs
INTERNATIONAL IMMUNOPHARMACOLOGY (2021) IF: 4.932
Role of vitamin D/VDR nuclear translocation in down-regulation of NF-κB/NLRP3/caspase-1 axis in lupus nephritis

DOI: 10.1016/j.intimp.2021.108131

PMID: 34536747
Sample: serum,Mouse renal tubular epithelial cells (mRTECs
INTERNATIONAL IMMUNOPHARMACOLOGY (2021) IF: 4.932
RGFP966 is protective against lipopolysaccharide-induced depressive-like behaviors in mice by inhibiting neuroinflammation and microglial activation

DOI: 10.1016/j.intimp.2021.108259

PMID: 34666303
Sample: hippocampal tissue
INTERNATIONAL IMMUNOPHARMACOLOGY (2021) IF: 4.932
Quercetin ameliorates Aspergillus fumigatus keratitis by inhibiting fungal growth, toll-like receptors and inflammatory cytokines

DOI: 10.1016/j.intimp.2021.107435

Sample: Tissue homogenate(corneas)
INTERNATIONAL IMMUNOPHARMACOLOGY (2021) IF: 4.932
Protective effect of combination of anakinra and MCC950 against acute lung injury is achieved through suppression of the NF-κB-mediated-MAPK and NLRP3-caspase pathways

DOI: 10.1016/j.intimp.2021.107506

PMID: 34022766
Sample: Tissue homogenate(lung),Bronchoalveolar Lavage Flu
INTERNATIONAL IMMUNOPHARMACOLOGY (2021) IF: 4.932
Oxymatrine inhibits neuroinflammation by Regulating M1/M2 polarization in N9 microglia through the TLR4/NF-κB pathway

DOI: 10.1016/j.intimp.2021.108139

Sample: N9 microglial cell
INTERNATIONAL IMMUNOPHARMACOLOGY (2022) IF: 4.932
New insights into the treatment mechanisms of Vitamin D on PM2.5-induced toxicity and inflammation in mouse renal tubular epithelial cells

DOI: 10.1016/j.intimp.2022.108747

PMID: 35429817
Sample: mRTECs
INTERNATIONAL IMMUNOPHARMACOLOGY (2022) IF: 4.932
Inhibition of P2Y6 receptor expression in Kupffer cells alleviates alcoholic steatohepatitis in mice

DOI: 10.1016/j.intimp.2022.108909

PMID: 35700583
Sample: serum,RAW264.7 cell
INTERNATIONAL IMMUNOPHARMACOLOGY (2022) IF: 4.932
High-density lipoprotein reduces microglia activation and protects against experimental autoimmune encephalomyelitis in mice

DOI: 10.1016/j.intimp.2022.108566

PMID: 35101849
Sample: plasma,BV2 microglial cell
INTERNATIONAL IMMUNOPHARMACOLOGY (2021) IF: 4.932
Empagliflozin, a sodium glucose cotransporter-2 inhibitor, ameliorates peritoneal fibrosis via suppressing TGF-β/Smad signaling

DOI: 10.1016/j.intimp.2021.107374

PMID: 33517222
Sample: peritoneal dialysis solution,Cell culture supernat
INTERNATIONAL IMMUNOPHARMACOLOGY (2021) IF: 4.932
Disulfiram inhibits IL-1β secretion and inflammatory cells recruitment in Aspergillus fumigatus keratitis

DOI: 10.1016/j.intimp.2021.108401

PMID: 34883353
Sample: primary macrophage
INTERNATIONAL IMMUNOPHARMACOLOGY (2020) IF: 4.932
COX-2-PGE2 signaling pathway contributes to hippocampal neuronal injury and cognitive impairment in PTZ-kindled epilepsy mice

DOI: 10.1016/j.intimp.2020.106801

Sample: Tissue homogenate
INTERNATIONAL IMMUNOPHARMACOLOGY (2021) IF: 4.932
Bixin protects mice against bronchial asthma though modulating PI3K/Akt pathway

DOI: 10.1016/j.intimp.2021.108266

PMID: 34678694
Sample: BALF
INTERNATIONAL IMMUNOPHARMACOLOGY (2022) IF: 4.932
Atractyloside-A ameliorates spleen deficiency diarrhea by interfering with TLR4/MyD88/NF-κB signaling activation and regulating intestinal flora homeostasis

DOI: 10.1016/j.intimp.2022.108679

PMID: 35279514
Sample: colon tissue
INTERNATIONAL IMMUNOPHARMACOLOGY (2021) IF: 4.932
Astragaloside IV ameliorates steroid-induced osteonecrosis of the femoral head by repolarizing the phenotype of pro-inflammatory macrophages

DOI: 10.1016/j.intimp.2020.107345

PMID: 33563553
Sample: Tissue homogenate
INTERNATIONAL IMMUNOPHARMACOLOGY (2021) IF: 4.932
Artesunate attenuates atherosclerosis by inhibiting macrophage M1-like polarization and improving metabolism

DOI: 10.1016/j.intimp.2021.108413

PMID: 34891003
Sample: plasma
INTERNATIONAL IMMUNOPHARMACOLOGY (2022) IF: 4.932
ACT001 suppressing M1 polarization against inflammation via NF-κB and STAT1 signaling pathways alleviates acute lung injury in mice

DOI: 10.1016/j.intimp.2022.108944

PMID: 35728304
Sample: BALF
BIOCHEMICAL PHARMACOLOGY (2020) IF: 4.96
Perillaldehyde: A promising antifungal agent to treat oropharyngeal candidiasis

DOI: 10.1016/j.bcp.2020.114201

PMID: 32822688
Sample: Tissue homogenate
PPAR Research (2019) IF: 4.964
Arsenic Trioxide in Synergy with Vitamin D Rescues the Defective VDR-PPAR- Functional Module of Autophagy in Rheumatoid Arthritis

DOI: 10.1155/2019/6403504

Sample: serum
FASEB JOURNAL (2020) IF: 4.966
CaMK4‐dependent phosphorylation of Akt/mTOR underlies Th17 excessive activation in experimental autoimmune prostatitis

DOI: 10.1096/fj.201902910RRR

Sample: Cell culture supernatant,Tissue homogenate,serum
Scientific Reports (2022) IF: 4.996
IL-37 alleviates Coxsackievirus B3-induced viral myocarditis via inhibiting NLRP3 inflammasome-mediated pyroptosis

DOI: 10.1038/s41598-022-22617-y

Sample: serum
Contrast Media & Molecular Imaging (2022) IF: 3.009
lncRNA SNHG12 Inhibition Based on Microsystem Cell Imaging Technology Protects the Endothelium from LPS-Induced Inflammation by Inhibiting the Expression of miR-140-3p Target Gene fndc5

DOI: 10.1155/2022/1681864

PMID: 36034208
Sample: BALF,PMVEC
JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY (2021) IF: 3.011
Rhamnetin ameliorates macrophage-mediated inflammation and pro-atherosclerosis pathways in apolipoprotein E-deficient mice

DOI: 10.26402/jpp.2021.2.10

Sample: aorta
Cardiovascular Therapeutics (2022) IF: 3.023
L-Carnitine Alleviates the Myocardial Infarction and Left Ventricular Remodeling through Bax/Bcl-2 Signal Pathway

DOI: 10.1155/2022/9615674

PMID: 35692375
Sample: plasma
European Review for Medical and Pharmacological Sciences (2020) IF: 3.024
MiR-181-5p protects mice from sepsis via repressing HMGB1 in an experimental model

DOI: 10.26355/eurrev_202009_23063

PMID: 33015817
Sample: Serum
European Review for Medical and Pharmacological Sciences (2020) IF: 3.024
Effect of β-casomorphin-7 on myocardial hypertrophy in hyperthyroidism-induced cardiomyopathy

DOI: 10.26355/eurrev_202006_21536

PMID: 32572935
Sample: Serum,Tissue homogenate
NEUROCHEMICAL RESEARCH (2020) IF: 3.038
Bexarotene Improve Depression-Like Behaviour in Mice by Protecting Against Neuro-inflammation and Synaptic Damage

DOI: 10.1007/s11064-020-03012-3

PMID: 32170675
Sample: Tissue homogenate
IMMUNOLOGICAL INVESTIGATIONS (2022) IF: 3.044
Knockdown of PHLDA1 Alleviates Necrotizing Enterocolitis by Inhibiting NLRP3 Inflammasome Activation and Pyroptosis Through Enhancing Nrf2 Signaling

DOI: 10.1080/08820139.2022.2161910

Sample: intestinal tissues
MOLECULES (2019) IF: 3.06
MMI-0100 Ameliorates Dextran Sulfate Sodium-Induced Colitis in Mice through Targeting MK2 Pathway

DOI: 10.3390/molecules24152832

Sample: colon
MOLECULES (2019) IF: 3.06
MMI-0100 Ameliorates Dextran Sulfate Sodium-Induced Colitis in Mice through Targeting MK2 Pathway

DOI: 10.3390/molecules24152832

Sample: colon
MOLECULES (2019) IF: 3.06
Design, Synthesis and Investigation of the Potential Anti-Inflammatory Activity of 7-O-Amide Hesperetin Derivatives

DOI: 10.3390/molecules24203663

PMID: 31614601
Sample: Cell culture supernatant
American Journal of Translational Research (2018) IF: 3.061
Diosgenin glucoside protects against myocardial injury in diabetic mice by inhibiting RIP140 signaling

PMID: 30662624
Sample: serum,cardiac tissue
CYTOKINE (2019) IF: 3.078
6-Gingerol attenuates macrophages pyroptosis via the inhibition of MAPK signaling pathways and predicts a good prognosis in sepsis

DOI: 10.1016/j.cyto.2019.154854

PMID: 31539844
Sample: Cell culture supernatant
BMC Pregnancy and Childbirth (2022) IF: 3.105
The preventive effect of low-dose aspirin in a PPAR-γ antagonist treated mouse model of preeclampsia

DOI: 10.1186/s12884-022-04901-x

PMID: 35906540
Sample: plasma
Frontiers in Bioscience-Landmark (2023) IF: 3.115
β-arrestin2 Mediates the Arginine Vasopressin-Induced Expression of IL-1β in Murine Hearts

DOI: 10.31083/j.fbl2801007

Sample: serum,heart
INTERNATIONAL IMMUNOPHARMACOLOGY (2018) IF: 3.118
Interaction of mannose binding lectin and other pattern recognition receptors in human corneal epithelial cells during Aspergillus fumigatus infection

DOI: 10.1016/j.intimp.2018.08.003

PMID: 30096599
Sample: Tissue homogenate
INTERNATIONAL IMMUNOPHARMACOLOGY (2018) IF: 3.118
B-cell-specific mammalian target of rapamycin complex 1 activation results in severe osteoarthritis in mice

DOI: 10.1016/j.intimp.2018.09.038

Sample: serum
Journal of Pain Research (2022) IF: 3.133
Anti-Nociceptive and Anti-Inflammatory Activities of the Ethyl Acetate Extract of Belamcanda chinensis (L.) Redouté in Raw 264.7 Cells in vitro and Mouse Model in vivo

DOI: 10.2147/JPR.S353357

PMID: 35502404
Sample: RAW264.7 cell
EXPERIMENTAL BIOLOGY AND MEDICINE (2020) IF: 3.139
Exosomes derived from synovial fibroblasts under hypoxia aggravate rheumatoid arthritis by regulating Treg/Th17 balance:

DOI: 10.1177/1535370220934736

Sample: Cell culture medium
International Journal of Chronic Obstructive Pulmonary Disease (2017) IF: 3.157
Repression of Toll-like receptor-4 by microRNA-149-3p is associated with smoking-related COPD

DOI: 10.2147/COPD.S128031

Sample: Cell culture supernatant
Journal of Functional Foods (2019) IF: 3.197
The protective effects of Chinese yam polysaccharide against obesity-induced insulin resistance

DOI: 10.1016/j.jff.2019.02.023

Sample: Serum
Journal of Functional Foods (2019) IF: 3.197
Anti-fatigue activity of purified anthocyanins prepared from purple passion fruit (P. edulis Sim) epicarp in mice

DOI: 10.1016/j.jff.2019.103725

Sample: Tissue homogenate
DIGESTIVE DISEASES AND SCIENCES (2019) IF: 3.199
Role of Interleukin-17 in Pathogenesis of Intestinal Fibrosis in Mice

DOI: 10.1007/s10620-019-05969-w

Sample: blood
INFLAMMATION (2020) IF: 3.212
miR-128-3p Inhibits NRP1 Expression and Promotes Inflammatory Response to Acute Kidney Injury in Sepsis

DOI: 10.1007/s10753-020-01251-8

Sample: TCMK-1 cell
ACTA PHARMACOLOGICA SINICA (2017) IF: 3.223
Osthole prevents acetaminophen-induced liver injury in mice

DOI: 10.1038/aps.2017.129

Sample: Tissue homogenate
ACTA PHARMACOLOGICA SINICA (2017) IF: 3.223
Molecular mechanisms of the analgesic action of Wu-tou Decoction on neuropathic pain in mice revealed using microarray and network analysis

DOI: 10.1038/aps.2017.110

Sample: Tissue homogenate
Cardiovascular Toxicology (2021) IF: 3.239
Diet-Derived Advanced Glycation End Products (dAGEs) Induce Proinflammatory Cytokine Expression in Cardiac and Renal Tissues of Experimental Mice: Protective Effect of Curcumin

DOI: 10.1007/s12012-021-09697-4

PMID: 34655413
Sample: serum
PLoS One (2021) IF: 3.24
Saffron extract attenuates neuroinflammation in rmTBI mouse model by suppressing NLRP3 inflammasome activation via SIRT1

DOI: 10.1371/journal.pone.0257211

PMID: 34506597
Sample: brain
IUBMB LIFE (2020) IF: 3.244
Blockade of high mobility group box 1 involved in the protective of curcumin on myocardial injury in diabetes in vivo and in vitro

DOI: 10.1002/iub.2226

PMID: 31909882
Sample: Serum
EUROPEAN JOURNAL OF PHARMACOLOGY (2020) IF: 3.263
Pancreastatin inhibitor PSTi8 protects the obesity associated skeletal muscle insulin resistance in diet induced streptozotocin-treated diabetic mice

DOI: 10.1016/j.ejphar.2020.173204

Sample: plasma
MOLECULES (2020) IF: 3.267
A Herbal Mixture from Propolis, Pomegranate, and Grape Pomace Endowed with Anti-Inflammatory Activity in an In Vivo Rheumatoid Arthritis Model

DOI: 10.3390/molecules25092255

Sample: serum
Bioengineered (2021) IF: 3.269
The protective effects of S14G-humanin (HNG) against mono-sodium urate (MSU) crystals- induced gouty arthritis

DOI: 10.1080/21655979.2021.2001911

PMID: 34965184
Sample: BMDMs
Bioengineered (2021) IF: 3.269
The protective effects of Pimavanserin against cerebral ischemia-induced brain injury

DOI: 10.1080/21655979.2021.1978617

PMID: 34605354
Sample: brain tissue
Bioengineered (2021) IF: 3.269
Synergetic protective effect of berberine and ginsenoside Rb1 against tumor necrosis factor alpha−induced inflammation in adipocytes

DOI: 10.1080/21655979.2021.1996508

Sample: 3T3-L1 preadipocyte
Bioengineered (2022) IF: 3.269
Shikonin combined with methotrexate regulate macrophage polarization to treat psoriasis

DOI: 10.1080/21655979.2022.2062090

PMID: 35485255
Sample: RAW264.7 cell
Bioengineered (2021) IF: 3.269
Protective effect of dexmedetomidine in cecal ligation perforation-induced acute lung injury through HMGB1/RAGE pathway regulation and pyroptosis activation

DOI: 10.1080/21655979.2021.2000723

PMID: 34747306
Sample: bronchoalveolar lavage fluid (BALF)
Bioengineered (2022) IF: 3.269
Guizhi Fuling pill attenuates liver fibrosis in vitro and in vivo via inhibiting TGF-β1/Smad2/3 and activating IFN-γ/Smad7 signaling pathways

DOI: 10.1080/21655979.2022.2054224

PMID: 35387552
Sample: liver tissue
NEUROSCIENCE (2017) IF: 3.277
Blocking the CD38/cADPR pathway plays a double-edged role in LPS stimulated microglia

DOI: 10.1016/j.neuroscience.2017.08.010

Sample: Cell culture supernatant
FISH & SHELLFISH IMMUNOLOGY (2019) IF: 3.298
Anti-inflammatory effect of a novel synthetic compound 1-((4-fluorophenyl)thio)isoquinoline in RAW264.7 macrophages and a zebrafish model

DOI: 10.1016/j.fsi.2019.01.030

Sample: Cell culture supernatant
CELL CYCLE (2018) IF: 3.304
MicroRNA-27a alleviates LPS-induced acute lung injury in mice via inhibiting inﬂammation and apoptosis through modulating TLR4/MyD88/NF-κB pathway

DOI: 10.1080/15384101.2018.1509635

Sample: bronchoalveolar lavage fluid (BALF),RAW 264.7 cell
NEUROTOXICITY RESEARCH (2019) IF: 3.311
The Elastin-Derived Peptide VGVAPG Does Not Activate the Inflammatory Process in Mouse Cortical Astrocytes In Vitro

DOI: 10.1007/s12640-019-00114-x

Sample: mouse astrocyte cell
INTERNATIONAL IMMUNOPHARMACOLOGY (2019) IF: 3.361
Regulation of CD39 expression in ATP-P2Y2R-mediated alcoholic liver steatosis and inflammation

DOI: 10.1016/j.intimp.2019.105915

PMID: 31639617
Sample: Serum,Cell culture supernatant
INTERNATIONAL IMMUNOPHARMACOLOGY (2019) IF: 3.361
Icariin targets Nrf2 signaling to inhibit microglia-mediated neuroinflammation

DOI: 10.1016/j.intimp.2019.05.033

Sample: primary microglia,BV2 cells
CELLULAR & MOLECULAR BIOLOGY LETTERS (2019) IF: 3.367
Tetrahydroxy stilbene glucoside alleviates palmitic acid-induced inflammation and apoptosis in cardiomyocytes by regulating miR-129-3p/Smad3 signaling

DOI: 10.1186/s11658-018-0125-x

PMID: 30820195
Sample: Cell culture supernatant
CELLULAR & MOLECULAR BIOLOGY LETTERS (2019) IF: 3.367
Honokiol alleviates sepsis-induced acute kidney injury in mice by targeting the miR-218-5p/heme oxygenase-1 signaling pathway

DOI: 10.1186/s11658-019-0142-4

PMID: 30833971
Sample: Serum
BRAIN RESEARCH BULLETIN (2020) IF: 3.37
Biological evaluation of naturally occurring bulbocodin D as a potential multi-target agent for Alzheimer’s disease

DOI: 10.1016/j.brainresbull.2020.09.017

Sample: Cell culture supernatant
American Journal of Translational Research (2020) IF: 3.375
Overexpression of lncRNA Gm43050 alleviates apoptosis and inflammation response induced by sevoflurane treatment by regulating miR-640/ZFP91

PMID: 32913509
Sample: primary hippocampal neurons
JOURNAL OF DRUG TARGETING (2020) IF: 3.38
Development, optimisation and evaluation of chitosan nanoparticles of alendronate against Alzheimer’s disease in intracerebroventricular streptozotocin model for brain delivery

DOI: 10.1080/1061186X.2020.1817041

Sample: Tissue homogenate
EXPERIMENTAL CELL RESEARCH (2020) IF: 3.383
iTRAQ-based proteomics and in vitro experiments reveals essential roles of ACE and AP-N in the renin–angiotensin system-mediated congenital ureteropelvic junction obstruction

DOI: 10.1016/j.yexcr.2020.112086

Sample: Serum,Cell sample
PPAR Research (2018) IF: 3.386
Portulaca Extract Attenuates Development of Dextran Sulfate Sodium Induced Colitis in Mice through Activation of PPARγ

DOI: 10.1155/2018/6079101

Sample: serum
JOURNAL OF BIOCHEMISTRY (2022) IF: 3.387
Lidocaine relieves spinal cord ischemia-reperfusion injury via long non-coding RNA MIAT-mediated Notch1 downregulation

DOI: 10.1093/jb/mvab150

PMID: 34981118
Sample: serum,BV2 cell
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2018) IF: 3.388
Aspergillus fumigatus Increased PAR-2 Expression and Elevated Proinflammatory Cytokines Expression Through the Pathway of PAR-2/ERK1/2 in Cornea

DOI: 10.1167/iovs.17-21887

PMID: 29332129
Sample: Tissue homogenate
Brain Sciences (2022) IF: 3.394
Suppressive Effects of Gelsemine on Anxiety-like Behaviors Induced by Chronic Unpredictable Mild Stress in Mice

DOI: 10.3390/brainsci12020191

PMID: 35203954
Sample: brain tissue
MOLECULAR AND CELLULAR BIOCHEMISTRY (2020) IF: 3.396
Curcumin amends Ca 2+ dysregulation in microglia by suppressing the activation of P2X7 receptor

DOI: 10.1007/s11010-019-03668-8

Sample: brain,serum
Brain and Behavior (2022) IF: 3.405
MiR-340-5p alleviates neuroinflammation and neuronal injury via suppressing STING in subarachnoid hemorrhage

DOI: 10.1002/brb3.2687

PMID: 35957622
Sample: brain tissue,microglia
Biomed Research International (2021) IF: 3.411
VX765, a Specific Caspase-1 Inhibitor, Alleviates Lung Ischemia Reperfusion Injury by Suppressing Endothelial Pyroptosis and Barrier Dysfunction

DOI: 10.1155/2021/4525988

PMID: 34977239
Sample: lung tissue,serum,PMVEC
Biomed Research International (2021) IF: 3.411
Protective Effect of Luteolin on D-Galactosamine (D-Gal)/Lipopolysaccharide (LPS) Induced Hepatic Injury by in Mice

DOI: 10.1155/2021/2252705

PMID: 34368345
Sample: serum,liver
Biomed Research International (2021) IF: 3.411
Effect and Mechanism of Mycobacterium tuberculosis Lipoprotein LpqH in NLRP3 Inflammasome Activation in Mouse Ana-1 Macrophage

DOI: 10.1155/2021/8239135

PMID: 33490276
Sample: Cell supernatant
JOURNAL OF CELLULAR BIOCHEMISTRY (2019) IF: 3.448
Attractylone attenuates sepsis‐associated encephalopathy and cognitive dysfunction by inhibiting microglial activation and neuroinflammation

DOI: 10.1002/jcb.27983

Sample: Cell culture supernatant,Tissue homogenate
BIOMEDICINE & PHARMACOTHERAPY (2018) IF: 3.457
The protective effect of formononetin on cognitive impairment in streptozotocin (STZ)-induced diabetic mice

DOI: 10.1016/j.biopha.2018.07.063

Sample: Serum,Tissue homogenate
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2020) IF: 3.47
Honokiol Reduces Fungal Load, Toll-Like Receptor-2, and Inflammatory Cytokines in Aspergillus fumigatus Keratitis

DOI: 10.1167/iovs.61.4.48

PMID: 32347916
Sample: Cell culture supernatant
JOURNAL OF ORTHOPAEDIC RESEARCH (2020) IF: 3.494
Curcumin prevents osteocyte apoptosis by inhibiting M1‐type macrophage polarization in mice model of glucocorticoid‐associated osteonecrosis of the femoral head

DOI: 10.1002/jor.24619

Sample: peripheral blood
TOXICOLOGY IN VITRO (2021) IF: 3.5
(3α)-3-(tiglinoyloxy)-ent-kaur-16-en-19-oic acid, isolated from Wedelia trilobata L., exerts an anti-inflammatory effect via the modulation of NF-κB, MAPK and mTOR pathway and autophagy in LPS-stimulated macrophages

DOI: 10.1016/j.tiv.2021.105139

PMID: 33705895
Sample: Cell culture supernatant
Journal of Personalized Medicine (2022) IF: 3.508
NLRP6 Induces Lung Injury and Inflammation Early in Brucella and Influenza Coinfection

DOI: 10.3390/jpm12122063

Sample: lung tissues
ACS Omega (2022) IF: 3.512
Effects of Different Radiation Sources on the Performance of Collagen-Based Corneal Repair Materials and Macrophage Polarization

DOI: 10.1021/acsomega.2c01875

PMID: 35811904
Sample: RAW264.7 macrophages
ACS Omega (2021) IF: 3.512
Curcumin Reduces Cognitive Deficits by Inhibiting Neuroinflammation through the Endoplasmic Reticulum Stress Pathway in Apolipoprotein E4 Transgenic Mice

DOI: 10.1021/acsomega.0c04810

PMID: 33748578
Sample: Tissue homogenate(Brain)
Frontiers in Endocrinology (2018) IF: 3.519
Verapamil Ameliorates Hepatic Metaflammation by Inhibiting Thioredoxin-Interacting Protein/NLRP3 Pathways

DOI: 10.3389/fendo.2018.00640

Sample: Serum
PHOTOCHEMISTRY AND PHOTOBIOLOGY (2023) IF: 3.521
Dendrobium Nobile Lindl Polysaccharides Attenuate UVB-Induced Photodamage by Regulating Oxidative Stress, Inflammation and Mmps Expression in Mice Model

DOI: 10.1111/php.13780

Sample: skin
Toxicology Research (2021) IF: 3.524
The modulatory impacts of Glycyrrhiza glabra extract against methotrexate-induced testicular dysfunction and oxidative stress

DOI: 10.1093/toxres/tfab049

Sample: serum
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2018) IF: 3.569
Upregulated galectin-3 is not a critical disease mediator of cardiomyopathy induced by β2-adrenoceptor overexpression

DOI: 10.1152/ajpheart.00337.2017

Sample: left ventricle (LV) tissues
TOXICOLOGY LETTERS (2020) IF: 3.569
Methamphetamine induced neuroinflammation in mouse brain and microglial cell line BV2: Roles of the TLR4/TRIF/Peli1 signaling axis

DOI: 10.1016/j.toxlet.2020.07.028

PMID: 32768653
Sample: Cell culture supernatant,Tissue homogenate
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2022) IF: 3.575
Sulforaphane protects myocardium from ischemia-reperfusion injury by regulating CaMKIIN2 and CaMKIIδ

DOI: 10.1016/j.bbrc.2022.03.015

PMID: 35316762
Sample: H9c2 cell
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2022) IF: 3.575
Loss of serine/threonine protein kinase 25 in retinal ganglion cells ameliorates high glucose-elicited damage through regulation of the AKT-GSK-3β/Nrf2 pathway

DOI: 10.1016/j.bbrc.2022.02.044

PMID: 35217361
Sample: retina ganglion cell
NEUROSCIENCE (2022) IF: 3.59
Pharmacological Postconditioning by Protocatechuic Acid Attenuates Brain Injury in Ischemia–Reperfusion (I/R) Mice Model: Implications of Nuclear Factor Erythroid-2-Related Factor Pathway

DOI: 10.1016/j.neuroscience.2022.03.016

Sample: brain
BMC IMMUNOLOGY (2022) IF: 3.594
NLRP3 inflammasome up-regulates major histocompatibility complex class I expression and promotes inflammatory infiltration in polymyositis

DOI: 10.1186/s12865-022-00515-2

PMID: 35965334
Sample: Raw 264.7 cell
TOXICOLOGY AND APPLIED PHARMACOLOGY (2018) IF: 3.616
SIRT1 activation by butein attenuates sepsis-induced brain injury in mice subjected to cecal ligation and puncture via alleviating inflammatory and oxidative stress

DOI: 10.1016/j.taap.2018.10.013

PMID: 30336174
Sample: Serum,Tissue homogenate
LIFE SCIENCES (2020) IF: 3.647
Effects of taraxasterol against ethanol and high-fat diet-induced liver injury by regulating TLR4/MyD88/NF-κB and Nrf2/HO-1 signaling pathways

DOI: 10.1016/j.lfs.2020.118546

PMID: 33035580
Sample: Serum
LIFE SCIENCES (2020) IF: 3.647
DHCR24 overexpression modulates microglia polarization and inflammatory response via Akt/GSK3β signaling in Aβ25–35 treated BV-2 cells

DOI: 10.1016/j.lfs.2020.118470

Sample: Cell sample
JOURNAL OF FOOD BIOCHEMISTRY (2022) IF: 3.654
Viphyllin™, a standardized extract from black pepper seeds, mitigates intestinal inflammation, oxidative stress, and anxiety-like behavior in DSS-induced colitis mice

DOI: 10.1111/jfbc.14306

PMID: 35766031
Sample: colon tissue
JOURNAL OF FOOD BIOCHEMISTRY (2022) IF: 3.654
Exploring the potential of Lacticaseibacillus paracasei M11 on antidiabetic, anti-inflammatory, and ACE inhibitory effects of fermented dromedary camel milk (Camelus dromedaries) and the release of antidiabetic and anti-hypertensive peptides

DOI: 10.1111/jfbc.14449

PMID: 36206543
Sample: RAW 264.7 cells
METABOLIC BRAIN DISEASE (2022) IF: 3.655
CDGSH iron sulfur domain 2 mitigates apoptosis, oxidative stress and inflammatory response caused by oxygen–glucose deprivation/reoxygenation in HT22 hippocampal neurons by Akt-Nrf2-activated pathway

DOI: 10.1007/s11011-022-01043-z

Sample: HT22 neurons
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2023) IF: 3.688
Artesunate alleviates intracerebral hemorrhage secondary injury by inducing ferroptosis in M1-polarized microglia and suppressing inflammation through AMPK/mTORC1/GPX4 pathway

DOI: 10.1111/bcpt.13848

Sample: brain tissues
Journal of Functional Foods (2020) IF: 3.701
Comparison of the structural characteristics and immunostimulatory activities of polysaccharides from wild and cultivated Pleurotus feruleus

DOI: 10.1016/j.jff.2020.104050

Sample: serum
Biomedical Materials (2021) IF: 3.715
The osteoimmunomodulatory effect of nanostructured TiF x /TiO x coating on osteogenesis induction

DOI: 10.1088/1748-605X/ac0863

Sample: RAW264.7 cells
BRAIN RESEARCH BULLETIN (2023) IF: 3.715
IGF2 inhibits hippocampal over-activated microglia and alleviates depression-like behavior in LPS- treated male mice

DOI: 10.1016/j.brainresbull.2023.01.001

Sample: Serum
BRAIN RESEARCH BULLETIN (2023) IF: 3.715
Acetaldehyde dehydrogenase 2 activation attenuates sepsis-induced brain injury through NLRP3 inflammasome regulation

DOI: 10.1016/j.brainresbull.2023.01.012

Sample: HT22 cell
BIOLOGICAL TRACE ELEMENT RESEARCH (2021) IF: 3.738
Sodium P-aminosalicylic Acid Attenuates Manganese-Induced Neuroinflammation in BV2 Microglia by Modulating NF-κB Pathway

DOI: 10.1007/s12011-021-02581-w

PMID: 33447908
Sample: Cell culture supernatant(BV2 Cells)
BIOLOGICAL TRACE ELEMENT RESEARCH (2021) IF: 3.738
Borate Ameliorates Sodium Nitrite-Induced Oxidative Stress Through Regulation of Oxidant/Antioxidant Status: Involvement of the Nrf2/HO-1 and NF-κB Pathways

DOI: 10.1007/s12011-021-02613-5

PMID: 33559025
Sample: Serum
Marine Drugs (2019) IF: 3.772
Pepsin-Soluble Collagen from the Skin of Lophius litulo: A Preliminary Study Evaluating Physicochemical, Antioxidant, and Wound Healing Properties

DOI: 10.3390/md17120708

Sample: serum
SURFACE & COATINGS TECHNOLOGY (2020) IF: 3.784
In vitro and in vivo biocompatibility study of surface modified TiN deposited on Ti6Al4V using high-power impulse magnetron sputtering technique

DOI: 10.1016/j.surfcoat.2020.125814

Sample: skin
NEUROCHEMISTRY INTERNATIONAL (2020) IF: 3.881
Hesperidin alleviates chronic restraint stress and lipopolysaccharide-induced Hippocampus and Frontal cortex damage in mice: Role of TLR4/NF-κB, p38 MAPK/JNK, Nrf2/ARE signaling

DOI: 10.1016/j.neuint.2020.104835

PMID: 32853749
Sample: Serum
Food & Nutrition Research (2021) IF: 3.894
Effects of different doses of omega-3 polyunsaturated fatty acids on gut microbiota and immunity

DOI: 10.29219/fnr.v65.6263

PMID: 34349613
Sample: serum
Frontiers in Medicine (2020) IF: 3.9
Adiponectin Inhibits NLRP3 Inflammasome Activation in Nonalcoholic Steatohepatitis via AMPK-JNK/ErK1/2-NFκB/ROS Signaling Pathways

DOI: 10.3389/fmed.2020.546445

PMID: 33251225
Sample: Tissue homogenate(liver tissue)
JOURNAL OF CELLULAR PHYSIOLOGY (2018) IF: 3.923
Blocking PI3K/AKT signaling inhibits bone sclerosis in subchondral bone and attenuates post‐traumatic osteoarthritis

DOI: 10.1002/jcp.26460

Sample: serum,preosteoblasts
BIOORGANIC CHEMISTRY (2018) IF: 3.929
Assessment of novel azaanthraquinone derivatives as potent multi-target inhibitors of inflammation and amyloid-β aggregation in Alzheimer’s disease

DOI: 10.1016/j.bioorg.2018.10.073

Sample: Cell culture medium
INTERNATIONAL IMMUNOPHARMACOLOGY (2020) IF: 3.943
Saikosaponin-d attenuated lipopolysaccharide-induced depressive-like behaviors via inhibiting microglia activation and neuroinflammation

DOI: 10.1016/j.intimp.2019.106181

PMID: 31926446
Sample: Cell sample,Tissue homogenate
INTERNATIONAL IMMUNOPHARMACOLOGY (2020) IF: 3.943
NLRP12 negatively regulates EtOH-induced liver macrophage activation via NF-κB pathway and mediates hepatocyte apoptosis in alcoholic liver injury

DOI: 10.1016/j.intimp.2020.106968

PMID: 33182058
Sample: serum,RAW 264.7 cell
INTERNATIONAL IMMUNOPHARMACOLOGY (2020) IF: 3.943
Myricitrin pretreatment ameliorates mouse liver ischemia reperfusion injury

DOI: 10.1016/j.intimp.2020.107005

PMID: 33045574
Sample: Serum
INTERNATIONAL IMMUNOPHARMACOLOGY (2020) IF: 3.943
miR-129-5p alleviates LPS-induced acute kidney injury via targeting HMGB1/TLRs/NF-kappaB pathway

DOI: 10.1016/j.intimp.2020.107016

PMID: 33039954
Sample: Serum
INTERNATIONAL IMMUNOPHARMACOLOGY (2020) IF: 3.943
Inhibition of LOX-1 prevents inflammation and photoreceptor cell death in retinal degeneration

DOI: 10.1016/j.intimp.2020.106190

PMID: 31945611
Sample: Cell culture supernatant
INTERNATIONAL IMMUNOPHARMACOLOGY (2020) IF: 3.943
Inhibition of HMGB1 involved in the protective of salidroside on liver injury in diabetes mice

DOI: 10.1016/j.intimp.2020.106987

PMID: 33217691
Sample: Cell culture supernatant,Serum,Tissue homogenate
INTERNATIONAL IMMUNOPHARMACOLOGY (2020) IF: 3.943
Didymin ameliorates dexamethasone-induced non-alcoholic fatty liver disease by inhibiting TLR4/NF-κB and PI3K/Akt pathways in C57BL/6J mice

DOI: 10.1016/j.intimp.2020.107003

PMID: 33182043
Sample: Tissue homogenate
INTERNATIONAL IMMUNOPHARMACOLOGY (2020) IF: 3.943
Betulin alleviates on myocardial inflammation in diabetes mice via regulating Siti1/NLRP3/NF-κB pathway

DOI: 10.1016/j.intimp.2020.106653

Sample: serum,heart
INTERNATIONAL IMMUNOPHARMACOLOGY (2020) IF: 3.943
4-hydroxybenzo[d]oxazol-2(3H)-one ameliorates LPS/D-GalN-induced acute liver injury by inhibiting TLR4/NF-κB and MAPK signaling pathways in mice

DOI: 10.1016/j.intimp.2020.106445

PMID: 32272395
Sample: Tissue homogenate
NEUROCHEMICAL RESEARCH (2021) IF: 3.996
Platinum nanoparticles Protect Against Lipopolysaccharide-Induced Inflammation in Microglial BV-2 Cells via Decreased Oxidative Damage and Increased Phagocytosis

DOI: 10.1007/s11064-021-03434-7

PMID: 34432181
Sample: BV-2 cell
Scientific Reports (2020) IF: 3.998
Latexin deficiency in mice up-regulates inflammation and aggravates colitis through HECTD1/Rps3/NF-κB pathway

DOI: 10.1038/s41598-020-66789-x

PMID: 32555320
Sample: Serum
BIOELECTROMAGNETICS (2021) IF: 2.01
Effects of Pulsed Electromagnetic Field Therapy at Different Frequencies on Bone Mass and Microarchitecture in Osteoporotic Mice

DOI: 10.1002/bem.22344

PMID: 34082467
Sample: serum
MOLECULAR DIVERSITY (2019) IF: 2.032
Hybrids of oxoisoaporphine–tetrahydroisoquinoline: novel multi-target inhibitors of inflammation and amyloid-β aggregation in Alzheimer’s disease

DOI: 10.1007/s11030-018-9905-5

Sample: Cell culture medium
CHEMISTRY & BIODIVERSITY (2020) IF: 2.039
Integrating Network Pharmacology and Component Analysis Study on Anti-Atherosclerotic Mechanisms of Total Flavonoids of Engelhardia roxburghiana Leaves in Mice

DOI: 10.1002/cbdv.201900629

Sample: Thoracic aortas
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY (2019) IF: 2.041
Role of Brd4 in the production of inflammatory cytokines in mouse macrophages treated with titanium particles

DOI: 10.1139/cjpp-2019-0142

PMID: 31330113
Sample: Cell culture supernatant
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2019) IF: 2.058
Antihypernociceptive and neuroprotective effects of Combretin A and Combretin B on streptozotocin-induced diabetic neuropathy in mice

DOI: 10.1007/s00210-019-01626-1

PMID: 30759263
Sample: Serum,Spinal cord
Molecular Medicine Reports (2020) IF: 2.1
Coenzyme Q10 alleviates sevoflurane‑induced neuroinflammation by regulating the levels of apolipoprotein E and phosphorylated tau protein in mouse hippocampal neurons

DOI: 10.3892/mmr.2020.11131

Sample: Tissue homogenate
LIPIDS (2019) IF: 2.144
Lipofundin Mediates the Major Inhibition of Intravenous Propofol in IL‐1β Secretion and Phagocytosis of Staphylococcus aureus‐Infected Macrophages

DOI: 10.1002/lipd.12207

Sample: Cell culture medium
International Journal of Peptide Research and Therapeutics (2022) IF: 2.191
Atrial Natriuretic Peptide (ANP) Suppress λ-Carrageenan-Induced Acute Paw Edema by Modulating Pro-inflammatory Genes in Swiss Albino Mice

DOI: 10.1007/s10989-022-10444-8

Sample: paw tissue
JOURNAL OF NEUROSCIENCE METHODS (2020) IF: 2.214
Frequent exposure to varied home cage sizes alters pain sensitivity and some key inflammation-related biomarkers

DOI: 10.1016/j.jneumeth.2020.108890

PMID: 32768413
Sample: Tissue homogenate
NEUROSCIENCE LETTERS (2020) IF: 2.274
FSC231 can alleviate paclitaxel-induced neuralgia by inhibiting PICK1 and affecting related factors

DOI: 10.1016/j.neulet.2020.135471

PMID: 33207243
Sample: Tissue homogenate
Biomed Research International (2020) IF: 2.276
miR-1929-3p Overexpression Alleviates Murine Cytomegalovirus-Induced Hypertensive Myocardial Remodeling by Suppressing Ednra/NLRP3 Inflammasome Activation

DOI: 10.1155/2020/6653819

PMID: 33457411
Sample: serum,heart
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015) IF: 2.297
Ghrelin ameliorates intestinal barrier dysfunction in experimental colitis by inhibiting the activation of nuclear factor-kappa B

DOI: 10.1016/j.bbrc.2015.01.083

Sample: Tissue homogenate
HISTOLOGY AND HISTOPATHOLOGY (2021) IF: 2.303
Death-associated protein kinase 1 correlates with podocyte apoptosis and renal damage and can be mediated by miR-361.

DOI: 10.14670/hh-18-358

Sample: renal podocytes
BMC Anesthesiology (2022) IF: 2.376
Aerobic exercise alleviates ventilator-induced lung injury by inhibiting NLRP3 inflammasome activation

DOI: 10.1186/s12871-022-01874-4

Sample: lung tissues
PeerJ (2020) IF: 2.379
The immunostimulatory activity of polysaccharides from Glycyrrhiza uralensis

DOI: 10.7717/peerj.8294

PMID: 32030319
Sample: Tissue homogenate
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE (2019) IF: 2.422
Effect and mechanism of citral against methicillin‐resistant Staphylococcus aureus in vivo

DOI: 10.1002/jsfa.9677

Sample: Serum
EXPERIMENTAL PHYSIOLOGY (2020) IF: 2.431
Knockout of MD1 contributes to sympathetic hyperactivity and exacerbates ventricular arrhythmias following heart failure with preserved ejection fraction via NLRP3 inflammasome activation

DOI: 10.1113/EP088390

PMID: 32240565
Sample: Tissue homogenate
Psychogeriatrics (2021) IF: 2.44
HMGB1 augments cognitive impairment in sepsis-associated encephalopathy by binding to MD-2 and promoting NLRP3-induced neuroinflammation

DOI: 10.1111/psyg.12794

PMID: 34931753
Sample: brain,serum
METABOLIC BRAIN DISEASE (2018) IF: 2.441
Gentiopicroside abrogates lipopolysaccharide-induced depressive-like behavior in mice through tryptophan-degrading pathway

DOI: 10.1007/s11011-018-0246-y

Sample: Plasma
Experimental and Therapeutic Medicine (2022) IF: 2.447
LincRNA‑EPS increases TGF‑β expression to inhibit the Wnt/β‑catenin pathway, VSMC osteoblastic differentiation and vascular calcification in diabetic mice

DOI: 10.3892/etm.2022.11352

Sample: serum
Experimental and Therapeutic Medicine (2017) IF: 2.447
Effects of sepsis on the metabolism of sphingomyelin and cholesterol in mice with liver dysfunction

DOI: 10.3892/etm.2017.5226

Sample: Plasma
Experimental and Therapeutic Medicine (2020) IF: 2.447
Clostridium butyricum protects intestinal barrier function via upregulation of tight junction proteins and activation of the Akt/mTOR signaling pathway in a mouse model of dextran sodium sulfate‑induced colitis

DOI: 10.3892/etm.2020.9138

Sample: Serum
International Journal of Rheumatic Diseases (2021) IF: 2.454
MiR-223-3p and miR-22-3p inhibit monosodium urate-induced gouty inflammation by targeting NLRP3

DOI: 10.1111/1756-185X.14089

PMID: 33650318
Sample: Tissue homogenate(air pouch)
TISSUE & CELL (2022) IF: 2.466
Upregulation of BRD7 protects podocytes against high glucose-induced apoptosis by enhancing Nrf2 in a GSK-3β-dependent manner

DOI: 10.1016/j.tice.2022.101813

PMID: 35550209
Sample: MPC-5 cell
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY (2020) IF: 2.477
Isolation, characterization and anti-inflammatory mechanism of probiotics in lipopolysaccharide-stimulated RAW 264.7 macrophages

DOI: 10.1007/s11274-020-02852-z

Sample: RAW 264.7 cell
MOLECULAR AND CELLULAR BIOCHEMISTRY (2018) IF: 2.561
-infected RAW264.7 cells

DOI: 10.1007/s11010-018-3348-2

Sample: cell
Neuropsychiatric Disease and Treatment (2021) IF: 2.57
Bushen Huoxue Acupuncture Inhibits NLRP1 Inflammasome-Mediated Neuronal Pyroptosis in SAMP8 Mouse Model of Alzheimer’s Disease

DOI: 10.2147/NDT.S279304

Sample: Cell lysate
Biomed Research International (2018) IF: 2.583
Upregulated TSG-6 Expression in ADSCs Inhibits the BV2 Microglia-Mediated Inflammatory Response

DOI: 10.1155/2018/7239181

Sample: BV2 cells
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2020) IF: 2.598
Activation of Paraventricular Melatonin Receptor 2 Mediates Melatonin-Conferred Cardioprotection Against Myocardial Ischemia/Reperfusion Injury

DOI: 10.1097/FJC.0000000000000851

Sample: PVN tissue
Evidence-based Complementary and Alternative Medicine (2022) IF: 2.63
Camelina sativa Oil Treatment Alleviates Castor Oil-Induced Diarrhea in ICR Mice by Regulating Intestinal Flora Composition

DOI: 10.1155/2022/5394514

PMID: 35178105
Sample: plasma
Evidence-based Complementary and Alternative Medicine (2022) IF: 2.63
Biejiajian Pill Ameliorates Diabetes-Associated Atherosclerosis through Inhibition of the NLRP3 Inflammasome

DOI: 10.1155/2022/9131178

PMID: 35692570
Sample: serum
BIOLOGICAL TRACE ELEMENT RESEARCH (2020) IF: 2.639
Sodium P-aminosalicylic Acid Inhibits Manganese-Induced Neuroinflammation in BV2 Microglial Cells via NLRP3-CASP1 Inflammasome Pathway

DOI: 10.1007/s12011-020-02471-7

PMID: 33156491
Sample: Cell sample
ARCHIVES OF ORAL BIOLOGY (2023) IF: 2.64
IL-37 alleviates alveolar bone resorption and inflammatory response through the NF-κB/NLRP3 signaling pathway in male mice with periodontitis

DOI: 10.1016/j.archoralbio.2023.105629

Sample: periodontal tissue
MEDICAL SCIENCE MONITOR (2021) IF: 2.649
Downregulating Gasdermin D Reduces Severe Acute Pancreatitis Associated with Pyroptosis

DOI: 10.12659/MSM.927968

PMID: 33582700
Sample: Serum
Evidence-based Complementary and Alternative Medicine (2022) IF: 2.65
Fu Fang Zhen Zhu Tiao Zhi Capsules Protect against Myocardial Ischemia by Inhibiting Cardiomyocyte Pyroptosis.

DOI: 10.1155/2022/4752360

Sample: serum,cardiomyocyte
Evidence-based Complementary and Alternative Medicine (2022) IF: 2.65
Exploring the Muscle Metabolomics in the Mouse Model of Sepsis-Induced Acquired Weakness

DOI: 10.1155/2022/6908488

PMID: 36016684
Sample: serum
Evidence-based Complementary and Alternative Medicine (2022) IF: 2.65
Anti-inflammatory Mechanism of Action of Benzoylmesaconine in Lipopolysaccharide-Stimulated RAW264.7 Cells

DOI: 10.1155/2022/7008907

PMID: 35873638
Sample: RAW264.7 cell
Innate Immunity (2021) IF: 2.68
Chrysosplenol D protects mice against LPS-induced acute lung injury by inhibiting oxidative stress, inflammation, and apoptosis via TLR4-MAPKs/NF-κB signaling pathways:

DOI: 10.1177/17534259211051069

Sample: Bronchoalveolar Lavage Fluid
Iranian Journal of Basic Medical Sciences (2021) IF: 2.699
Corilagin potential in inhibiting oxidative and inflammatory stress in LPS-induced murine macrophage cell lines (RAW 264.7)

DOI: 10.22038/IJBMS.2021.59348.13174

Sample: RAW 264.7 cell
PLACENTA (2015) IF: 2.71
The effect of maternal obesity on the expression and functionality of placental P-glycoprotein: Implications in the individualized transplacental digoxin treatment for fetal heart failure

DOI: 10.1016/j.placenta.2015.08.007

Sample: Plasma
JOURNAL OF FOOD BIOCHEMISTRY (2021) IF: 2.72
Impact of Thymus vulgaris extract on sodium nitrite-induced alteration of renal redox and oxidative stress: Biochemical, molecular, and immunohistochemical study

DOI: 10.1111/jfbc.13630

PMID: 33769578
Sample: Serum,Tissue homogenate(kidney)
JOURNAL OF FOOD BIOCHEMISTRY (2022) IF: 2.72
Broccoli microgreens have hypoglycemic effect by improving blood lipid and inflammatory factors while modulating gut microbiota in mice with type 2 diabetes

DOI: 10.1111/jfbc.14145

PMID: 35348219
Sample: serum
IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL (2022) IF: 2.723
The Berberis vulgaris L. extract berberine exerts its anti-oxidant effects to ameliorate cholesterol overloading–induced cell apoptosis in the primary mice hepatocytes: an in vitro study

DOI: 10.1007/s11626-022-00737-z

Sample: serum
IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL (2022) IF: 2.723
Hace1 overexpression mitigates myocardial hypoxia/reoxygenation injury via the effects on Keap1/Nrf2 pathway

DOI: 10.1007/s11626-022-00725-3

PMID: 36251153
Sample: Primary cardiac cells
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY (2022) IF: 2.73
Protective effects of endotoxin tolerance on peripheral lipopolysaccharide-induced neuroinflammation and dopaminergic neuronal injury

DOI: 10.1080/08923973.2022.2043900

PMID: 35260024
Sample: substantia nigra (SN)
EUROPEAN JOURNAL OF PHARMACOLOGY (2016) IF: 2.73
Liraglutide attenuates lipopolysaccharide-induced acute lung injury in mice

DOI: 10.1016/j.ejphar.2016.10.016

Sample: Bronchoalveolar Lavage Fluid
REDOX REPORT (2020) IF: 2.753
hnRNPK knockdown alleviates NLRP3 inflammasome priming by repressing FLIP expression in Raw264.7 macrophages

DOI: 10.1080/13510002.2020.1857157

PMID: 33269646
Sample: Cell culture supernatant
CNS & Neurological Disorders-Drug Targets (2019) IF: 2.761
Formononetin Ameliorates Cognitive Disorder via PGC-1α Pathway in Neuroinflammation Conditions in High-Fat Diet-Induced Mice

DOI: 10.2174/1871527318666190807160137

Sample: hippocampus
Plants-Basel (2020) IF: 2.762
Phytochemical, Cytotoxicity, Antioxidant and Anti-Inflammatory Effects of Psilocybe Natalensis Magic Mushroom

DOI: 10.3390/plants9091127

PMID: 32878164
Sample: Cell culture supernatant
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2018) IF: 2.784
miR-124/MCP-1 signaling pathway modulates the protective effect of itraconazole on acute kidney injury in a mouse model of disseminated candidiasis

DOI: 10.3892/ijmm.2018.3564

Sample: serum
BMC Complementary and Alternative Medicine (2020) IF: 2.833
Shen-ling-bai-zhu-san ameliorates inflammation and lung injury by increasing the gut microbiota in the murine model of Streptococcus pneumonia-induced pneumonia.

DOI: 10.1186/s12906-020-02958-9

Sample: Tissue homogenate
Diabetes Metabolic Syndrome and Obesity-Targets and Therapy (2020) IF: 2.842
Isomangiferin Attenuates Renal Injury in Diabetic Mice via Inhibiting Inflammation

DOI: 10.2147/DMSO.S276229

PMID: 33204133
Sample: Serum,Tissue homogenate
MOLECULES (2017) IF: 2.861
Capparis spinosa Fruit Ethanol Extracts Exert Different Effects on the Maturation of Dendritic Cells

DOI: 10.3390/molecules22010097

Sample: Cell culture supernatant
INFLAMMATION (2018) IF: 2.884
MiR-590-3p Attenuates Acute Kidney Injury by Inhibiting Tumor Necrosis Factor Receptor-Associated Factor 6 in Septic Mice

DOI: 10.1007/s10753-018-0921-5

PMID: 30392071
Sample: Serum
Frontiers in Neurology (2020) IF: 2.889
Ablation of GSDMD Improves Outcome of Ischemic Stroke Through Blocking Canonical and Non-canonical Inflammasomes Dependent Pyroptosis in Microglia

DOI: 10.3389/fneur.2020.577927

PMID: 33329317
Sample: BV2 cell
HUMAN & EXPERIMENTAL TOXICOLOGY (2022) IF: 2.903
Neurotoxic 18-kDa apolipoprotein E fragment production contributes to anesthetic sevoflurane-induced tau phosphorylation and neuroinflammation in vitro:

DOI: 10.1177/09603271221102519

Sample: neurons
MICROBIAL PATHOGENESIS (2020) IF: 2.914
Exposure time determines the protective effect of Trichinella spiralis on experimental colitis

DOI: 10.1016/j.micpath.2020.104263

PMID: 32442663
Sample: Serum
Analytical Cellular Pathology (2021) IF: 2.916
Establishment and Mechanism Study of a Primary Ovarian Insufficiency Mouse Model Using Lipopolysaccharide

DOI: 10.1155/2021/1781532

Sample: serum
INFLAMMATION (2019) IF: 2.939
Sinomenine Attenuates Cartilage Degeneration by Regulating miR-223-3p/NLRP3 Inflammasome Signaling

DOI: 10.1007/s10753-019-00986-3

PMID: 30847744
Sample: Serum,Cell culture supernatant
BIOSCIENCE REPORTS (2020) IF: 2.942
Atractylon treatment prevents sleep-disordered breathing-induced cognitive dysfunction by suppression of chronic intermittent hypoxia-induced M1 microglial activation

DOI: 10.1042/BSR20192800

PMID: 32490526
Sample: Cell culture supernatant
Molecular Medicine Reports (2021) IF: 2.952
α‑rhamnrtin‑3‑α‑rhamnoside exerts anti‑inflammatory effects on lipopolysaccharide‑stimulated RAW264.7 cells by abrogating NF‑κB and activating the Nrf2 signaling pathway

DOI: 10.3892/mmr.2021.12439

PMID: 34523697
Sample: RAW264.7 cell
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2019) IF: 2.965
Gastrodin attenuates neuroinflammation in DOI‐induce Tourette syndrome in rats

DOI: 10.1002/jbt.22302

Sample: Serum,Tissue homogenate
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2019) IF: 2.965
Gastrodin alleviates Tourette syndrome via Nrf‐2/HO‐1/HMGB1/NF‐кB pathway

DOI: 10.1002/jbt.22389

Sample: Tissue homogenate
International Journal of Ophthalmology (2019) IF: 1.189
Expression and role of calcitonin gene-related peptide in mouse Aspergillus fumigatus keratitis

DOI: 10.18240/ijo.2019.05.01

PMID: 31131225
Sample: Cell culture supernatant
NEUROREPORT (2018) IF: 1.266
Gentiopicroside protects neurons from astrocyte-mediated inflammatory injuries by inhibition of nuclear factor-κB and mitogen-activated protein kinase signaling pathways

DOI: 10.1097/WNR.0000000000001082

PMID: 29958245
Sample: Cell culture supernatant
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH (2020) IF: 1.287
Gallincin ameliorates colitis-associated inflammation and barrier function in mice based on network pharmacology prediction:

DOI: 10.1177/0300060520951023

Sample: homogenized colonic tissue
International Journal of Ophthalmology (2020) IF: 1.33
Anti-inflammatory effects of astaxanthin against fungal keratitis

DOI: 10.18240/ijo.2020.11.01

PMID: 33214996
Sample: Tissue homogenate(Corneas)
Experimental and Therapeutic Medicine (2018) IF: 1.41
miR‑148a inhibits pro‑inflammatory cytokines released by intervertebral disc cells by regulating the p38/MAPK pathway

DOI: 10.3892/etm.2018.6516

Sample: Cell culture supernatant
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH (2018) IF: 1.492
NLRP3 inflammasome signaling as an early molecular response is negatively controlled by miR-186 in CFA-induced prosopalgia mice

DOI: 10.1590/1414-431X20187602

Sample: Serum,Tissue homogenate
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2020) IF: 1.516
LncRNA TUG1 reverses LPS-induced cell apoptosis and inflammation of macrophage via targeting MiR-221-3p/SPRED2 axis

DOI: 10.1080/09168451.2020.1806704

PMID: 32841583
Sample: Tissue homogenate
BIOLOGICAL & PHARMACEUTICAL BULLETIN (2019) IF: 1.54
Chemerin-9 Peptide Enhances Memory and Ameliorates Aβ1-42-induced Object Memory Impairment in Mice

DOI: 10.1248/bpb.b19-00510

Sample: hippocampus
Oncology Letters (2018) IF: 1.664
The association between inflammation, the microbiome and urethane-induced pulmonary adenocarcinoma Corrigendum in /10.3892/ol.2018.9063

DOI: 10.3892/ol.2018.8167

Sample: Serum
BMC Pharmacology & Toxicology (2020) IF: 1.771
Impact of Lesinurad and allopurinol on experimental Hyperuricemia in mice: biochemical, molecular and Immunohistochemical study

DOI: 10.1186/s40360-020-0386-7

PMID: 32041665
Sample: Serum
Food Science & Nutrition (2020) IF: 1.797
Subcutaneous administration of casein attenuates atherosclerotic progression in male apoE-/- mice fed with high-fat diet

DOI: 10.1002/fsn3.1638

Sample: Plasma
Evidence-based Complementary and Alternative Medicine (2020) IF: 1.813
Antioxidant and Anti-Inflammatory Activities of Kigelia africana (Lam.) Benth.

DOI: 10.1155/2020/4352084

Sample: RAW 264.7 cell
Molecular Medicine Reports (2019) IF: 1.851
Synergistic protection of matrine and lycopene against lipopolysaccharide‑induced acute lung injury in mice

DOI: 10.3892/mmr.2019.10278

Sample: lung
Molecular Medicine Reports (2019) IF: 1.851
Kisspeptin‑13 inhibits bleomycin‑induced pulmonary fibrosis through GPR54 in mice

DOI: 10.3892/mmr.2019.10341

Sample: lung
Molecular Medicine Reports (2019) IF: 1.851
Kisspeptin‑13 inhibits bleomycin‑induced pulmonary fibrosis through GPR54 in mice

DOI: 10.3892/mmr.2019.10341

Sample: lung
Molecular Medicine Reports (2018) IF: 1.922
Oral supplementation with ursolic acid ameliorates sepsis-induced acute kidney injury in a mouse model by inhibiting oxidative stress and inflammatory responses

DOI: 10.3892/mmr.2018.8767

Sample: Serum
Molecular Medicine Reports (2018) IF: 1.922
Embelin inhibits abdominal aortic aneurysm through decreasing IL‑6‑induced STAT3 and NF‑κB inactivation

DOI: 10.3892/mmr.2018.9221

Sample: Aortic tissues
Molecular Medicine Reports (2018) IF: 1.922
Dioscin prevents LPS‑induced acute lung injury through inhibiting the TLR4/MyD88 signaling pathway via upregulation of HSP70

DOI: 10.3892/mmr.2018.8667

Sample: Serum,Tissue homogenate
Journal of Biomedical Research (2021)
Protective effects on acute hypoxic-ischemic brain damage in mfat-1 transgenic mice by alleviating neuroinflammation

DOI: 10.7555/JBR.35.20210107

Sample: brain tissue
Advances in Pharmacological and Pharmaceutical Sciences (2020)
Antihypernociceptive, Anxiolytic, and Antidepressant Properties of Aqueous and Ethanol Extracts of Dissotis thollonii Cogn. (Melastomataceae) in Mice

DOI: 10.1155/2020/8886894

PMID: 33015629
Sample: Serum,Tissue homogenate
Advances in Traditional Medicine (2020)
Anti-hypernociceptive effects of methanol extract of Boswellia dalzielii on STZ-induced diabetic neuropathic pain

DOI: 10.1007/s13596-019-00411-y

Sample: serum,sciatic nerves
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH (2021) IF: 0.533
Effect of ganoderic acid on diethylnitrosamine-induced liver cancer in mice

DOI: 10.4314/tjpr.v19i12.23

Sample: serum
FOOD SCIENCE AND BIOTECHNOLOGY (2019) IF: 0.888
Antioxidant and anti-inflammatory effects of an ethanol fraction from the Schisandra chinensis baillon hot water extract fermented using Lactobacilius paracasei subsp. tolerans

DOI: 10.1007/s10068-019-00626-4

Sample: RAW 264.7 cells
Journal of Oleo Science (2015) IF: 0.968
A Comparative Study of the Effects upon LPS Induced Macrophage RAW264.7 Inflammation in vitro of the Lipids of Hippocampus trimaculatus Leach

DOI: 10.5650/jos.ess15190

Sample: Cell culture supernatant

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DOI: 10.1016/j.bbi.2022.11.013
PMID: 36427810	Sample: serum

DOI: 10.1016/j.biomaterials.2022.121690
PMID: 35965114	Sample: Brain tissue

DOI: 10.1016/j.jconrel.2023.01.074
	Sample: brain tissues

DOI: 10.1016/j.redox.2022.102367
PMID: 35724543	Sample: serum,Kupffer cell (KCs)

DOI: 10.1186/s12951-021-00796-6
PMID: 33608025	Sample: Tissue（brain）

DOI: 10.1016/j.scitotenv.2023.161416
	Sample: mixed glial cell

DOI: 10.1111/bph.15949
PMID: 36082580	Sample: serum

DOI: 10.1016/j.envpol.2022.120217
PMID: 36155221	Sample: hippocampi

DOI: 10.1021/acs.analchem.2c01691
PMID: 35920602	Sample: hepatic tissue,epididymal fat tissue

DOI: 10.1016/j.ijbiomac.2022.07.043
PMID: 35835298	Sample: Raw 264.7 macrophages

DOI: 10.1002/art.42420
	Sample: BMDMs

DOI: 10.1016/j.molcel.2017.03.008
	Sample: Serum

DOI: 10.1038/s41413-018-0012-0
	Sample: Serum

DOI: 10.1111/bph.16061
	Sample: Plasma

DOI: 10.1186/s12974-021-02089-z
PMID: 33541361	Sample: Tissue homogenate(Hippocampal homogenate)

DOI: 10.1038/s41419-022-04962-y
PMID: 35739102	Sample: RAW264.7 cell

DOI: 10.1016/j.jcmgh.2022.11.005
	Sample: colon tissue

DOI: 10.1016/j.chemosphere.2020.128178
	Sample: interstitial fluid

DOI: 10.1016/j.ecoenv.2023.114527
	Sample: liver,serum

DOI: 10.1016/j.carbpol.2020.117218
PMID: 33278982	Sample: Tissue homogenate

DOI: 10.1155/2022/1030238
	Sample: serum,Human pulmonary alveolar epithelial cells (H

DOI: 10.1155/2022/9041914
	Sample: left lung tissue,bronchoalveolar lavage fluid (BAL

DOI: 10.1016/j.freeradbiomed.2022.06.221
PMID: 35714846	Sample: hippocampal tissue

DOI: 10.1016/j.freeradbiomed.2021.05.001
PMID: 33965566	Sample: Tissue homogenate

Mouse IL-1β(Interleukin 1 Beta) ELISA Kit

To Purchase E-EL-M0037

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Citations

BRAIN BEHAVIOR AND IMMUNITY (2022) IF: 19.227

CHEMICAL ENGINEERING JOURNAL (2022) IF: 16.744

BIOMATERIALS (2022) IF: 15.304

Arthritis & Rheumatology (2022) IF: 15.483

MOLECULAR CELL (2017) IF: 14.714

CHEMICAL ENGINEERING JOURNAL (2022) IF: 13.273

Bone Research (2019) IF: 13.567

Bone Research (2019) IF: 13.567

Bone Research (2018) IF: 12.354

Engineering (2022) IF: 12.834

JOURNAL OF CONTROLLED RELEASE (2023) IF: 11.467

Redox Biology (2022) IF: 11.799

JOURNAL OF NANOBIOTECHNOLOGY (2021) IF: 10.435

SCIENCE OF THE TOTAL ENVIRONMENT (2023) IF: 10.753

JOURNAL OF NANOBIOTECHNOLOGY (2023) IF: 9.429

BRITISH JOURNAL OF PHARMACOLOGY (2022) IF: 9.4730

BRITISH JOURNAL OF PHARMACOLOGY (2023) IF: 9.4730

Molecular Neurodegeneration (2020) IF: 9.599

JOURNAL OF PATHOLOGY (2023) IF: 9.8829

ENVIRONMENTAL POLLUTION (2022) IF: 9.988

ANALYTICAL CHEMISTRY (2022) IF: 8.0079

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022) IF: 8.025

Journal of Neuroinflammation (2021) IF: 8.3219

Journal of Neuroinflammation (2022) IF: 8.3219

Cell Death & Disease (2022) IF: 8.4689

Cell Death & Disease (2020) IF: 8.4689

Cellular and Molecular Gastroenterology and Hepatology (2022) IF: 8.7970

CHEMOSPHERE (2020) IF: 7.086

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2022) IF: 7.088

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2023) IF: 7.129

CARBOHYDRATE POLYMERS (2020) IF: 7.182

Oxidative Medicine and Cellular Longevity (2023) IF: 7.31

Oxidative Medicine and Cellular Longevity (2022) IF: 7.31

Oxidative Medicine and Cellular Longevity (2022) IF: 7.31

FREE RADICAL BIOLOGY AND MEDICINE (2022) IF: 7.376

FREE RADICAL BIOLOGY AND MEDICINE (2021) IF: 7.376

BIOMEDICINE & PHARMACOTHERAPY (2022) IF: 7.419

BIOMEDICINE & PHARMACOTHERAPY (2023) IF: 7.419

BIOMEDICINE & PHARMACOTHERAPY (2022) IF: 7.419

FOOD CHEMISTRY (2021) IF: 7.514

Frontiers in Immunology (2022) IF: 7.561

Frontiers in Immunology (2021) IF: 7.561

Frontiers in Immunology (2022) IF: 7.561

Journal of Materials Chemistry B (2022) IF: 7.571

Antioxidants (2022) IF: 7.675

SCIENCE OF THE TOTAL ENVIRONMENT (2022) IF: 7.963

AMERICAN JOURNAL OF CHINESE MEDICINE (2022) IF: 6.005

ANALYTICAL CHEMISTRY (2018) IF: 6.042

Frontiers in Cardiovascular Medicine (2022) IF: 6.05

Frontiers in Cardiovascular Medicine (2021) IF: 6.05

Neural Regeneration Research (2022) IF: 6.058

BIOCHEMICAL PHARMACOLOGY (2023) IF: 6.1

ACTA PHARMACOLOGICA SINICA (2021) IF: 6.15

FREE RADICAL BIOLOGY AND MEDICINE (2020) IF: 6.17

JOURNAL OF MEDICINAL CHEMISTRY (2020) IF: 6.205

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022) IF: 6.208

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022) IF: 6.208

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2020) IF: 6.291

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2021) IF: 6.291

Cell Death & Disease (2020) IF: 6.304

Antioxidants (2022) IF: 6.313

Food & Function (2023) IF: 6.317

Food & Function (2022) IF: 6.317

Journal of Materials Chemistry B (2021) IF: 6.331

JOURNAL OF CELLULAR PHYSIOLOGY (2021) IF: 6.384

International Journal of Nanomedicine (2022) IF: 6.4

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021) IF: 6.514

DOI: 10.1016/j.biopha.2022.113414
PMID: 36076538	Sample: serum

DOI: 10.1016/j.biopha.2023.114264
	Sample: RAW264.7 cell

DOI: 10.1016/j.biopha.2022.113648
PMID: 36108388	Sample: serum

DOI: 10.1016/j.foodchem.2021.129164
PMID: 33550022	Sample: Cell culture medium

DOI: 10.3389/fimmu.2022.731500
	Sample: RAW264.7 cell,Bone marrow-derived macrophages

DOI: 10.3389/fimmu.2021.709229
PMID: 34691022	Sample: serum

DOI: 10.1039/D2TB00114D
PMID: 36070420	Sample: corneas

DOI: 10.1016/j.scitotenv.2022.155558
PMID: 35504386	Sample: lungs,serum,,hearts

DOI: 10.1021/acs.analchem.8b04912
PMID: 30497260	Sample: Cell culture supernatant

DOI: 10.3389/fcvm.2021.768214
PMID: 35083298	Sample: serum