NFκB-p105/p50 Polyclonal Antibody

Uniprot : P19838
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      Catalog number:E-AB-61286

      Synonyms:DKFZp686C01211,DNA binding factor KBF1,DNA binding factor KBF1 EBP1,DNA-binding factor KBF1,EBP 1,EBP-1,EBP1,KBF1,MGC54151,nf b,NF kappa B,NF kappaB,NF kappabeta,NF kB1,NFkappaB,NFKB 1,NFKB p105,NFKB p50,Nfkb1,NFKB1,Nuclear factor kappa B DNA binding subunit,Nuclear factor kappa-B,subunit 1,Nuclear factor NF kappa B p105 subunit,Nuclear factor NF kappa B p50 subunit,Nuclear factor NF-kappa-B p50 subunit,Nuclear factor of kappa light chain gene enhancer in B cells 1,Nuclear factor of kappa light polypeptide gene enhancer in B cells 1,Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1,p105,p50,p84/NF-kappa-B1 p98,Transcription factor NFKB1

      Size:
      • 60μL
      • 120μL
      • 200μL
      Qty:
      - +
      Price: $129

      Host: Rabbit

      Reactivity: H,M

      Applications: WB,IHC,IF

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms DKFZp686C01211,DNA binding factor KBF1,DNA binding factor KBF1 EBP1,DNA-binding factor KBF1,EBP 1,EBP-1,EBP1,KBF1,MGC54151,nf b,NF kappa B,NF kappaB,NF kappabeta,NF kB1,NFkappaB,NFKB 1,NFKB p105,NFKB p50,Nfkb1,NFKB1,Nuclear factor kappa B DNA binding subunit,Nuclear factor kappa-B,subunit 1,Nuclear factor NF kappa B p105 subunit,Nuclear factor NF kappa B p50 subunit,Nuclear factor NF-kappa-B p50 subunit,Nuclear factor of kappa light chain gene enhancer in B cells 1,Nuclear factor of kappa light polypeptide gene enhancer in B cells 1,Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1,p105,p50,p84/NF-kappa-B1 p98,Transcription factor NFKB1
      Swissprot P19838
      Source Rabbit
      Reactivity Human,Mouse
      Immunogen Recombinant protein of human NFKB1
      Application WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213),IF
      Recommended dilution WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:100
      Concentration 1mg/ml
      Clonality Polyclonal

      Properties

      Cellular localization Nucleus. Cytoplasm. Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor.
      Isotype IgG
      Purification Affinity purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
      Background This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed.

      Images

      Western blot analysis of extracts of various cell lines with NFκB-p105/p50 Polyclonal Antibody

      Immunohistochemistry of paraffin-embedded mouse lung with NFκB-p105/p50 Polyclonal Antibody

      Immunofluorescence analysis of A549 cells with NFκB-p105/p50 Polyclonal Antibody

      Western blot analysis of extracts from normal (control) and NFκB-p105/p50 knockout (KO) HeLa cells, using NFκB-p105/p50 Polyclonal Antibody at dilution of 1:1000.

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