NLRP3 Polyclonal Antibody

Uniprot : Q96P20,Q8R4B8
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      Catalog number:E-AB-70161

      Synonyms:AGTAVPRL,AII/AVP,Angiotensin/vasopressin receptor AII/AVP like,Angiotensin/vasopressin receptor AII/AVP-like,C1orf7,Caterpiller protein 1.1,CIAS 1,CIAS1,CLR1.1,Cold autoinflammatory syndrome 1,Cold autoinflammatory syndrome 1 protein,Cryopyrin,Familial cold autoinflammatory syndrome,FCAS,FCU,LRR and PYD domains-containing protein 3,Muckle-Wells syndrome,MWS,NACHT,NACHT LRR and PYD containing protein 3,NALP 3,NALP3,NALP3,NLR family pyrin domain containing 3,NLRP3,PYPAF 1,PYPAF1,PYRIN containing APAF1 like protein 1,PYRIN-containing APAF1-like protein 1

      Size:
      • 60μL
      • 120μL
      • 200μL
      Qty:
      - +
      Price: $129

      Host: Rabbit

      Reactivity: H,M

      Applications: IHC

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms AGTAVPRL,AII/AVP,Angiotensin/vasopressin receptor AII/AVP like,Angiotensin/vasopressin receptor AII/AVP-like,C1orf7,Caterpiller protein 1.1,CIAS 1,CIAS1,CLR1.1,Cold autoinflammatory syndrome 1,Cold autoinflammatory syndrome 1 protein,Cryopyrin,Familial cold autoinflammatory syndrome,FCAS,FCU,LRR and PYD domains-containing protein 3,Muckle-Wells syndrome,MWS,NACHT,NACHT LRR and PYD containing protein 3,NALP 3,NALP3,NALP3,NLR family pyrin domain containing 3,NLRP3,PYPAF 1,PYPAF1,PYRIN containing APAF1 like protein 1,PYRIN-containing APAF1-like protein 1
      Swissprot Q96P20,Q8R4B8
      Source Rabbit
      Reactivity Human,Mouse
      Immunogen KLH conjugated Synthetic peptide corresponding to Mouse NLRP3
      Application IHC(Detection kit: E-IR-R217)
      Recommended dilution IHC 1:300-1:1000
      Concentration 0.65 mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Cytoplasm.
      Tissue specificity Predominantly expressed in macrophages. Also expressed in dendritic cells, B- and T-cells (at protein level). Expressed in LPS-treated granulocytes, but not in resting cells (at protein level). Expression in monocytes is very weak (at protein level). Expressed in stratified non-keratinizing squamous epithelium, including oral, esophageal and ectocervical mucosa and in the Hassall's corpuscles in the thymus. Also, detected in the stratified epithelium covering the bladder and ureter (transitional mucosa) (at protein level). Expressed in lung epithelial cells (at protein level). Expressed in chondrocytes. Expressed at low levels in resting osteoblasts.Highest expression level in blood.
      Isotype IgG
      Purification Affinity purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4
      Background This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid. 

      Images

      Immunohistochemistry analysis of paraffin-embedded Human tonsil using NLRP3 Polyclonal Antibody at dilution of 1:400.

      Immunohistochemistry analysis of paraffin-embedded mouse spleen using NLRP3 Polyclonal Antibody at dilution of 1:400.

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