PC Polyclonal Antibody

Uniprot : P11498
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
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    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-14289

      Synonyms:mitochondrial,OTTHUMP00000235155,OTTHUMP00000235156,PC,PCB,Pcx,PYC,Pyruvate carboxylase,Pyruvate carboxylase mitochondrial,Pyruvic carboxylase

      Size:
      • 20μL
      • 60μL
      • 120μL
      • 200μL
      Qty:
      - +
      Price: $69

      Host: Rabbit

      Reactivity: H,M,R

      Applications: WB,ELISA

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms mitochondrial,OTTHUMP00000235155,OTTHUMP00000235156,PC,PCB,Pcx,PYC,Pyruvate carboxylase,Pyruvate carboxylase mitochondrial,Pyruvic carboxylase
      Swissprot P11498
      Source Rabbit
      Reactivity Human,Mouse,Rat
      Immunogen Recombinant protein of human PC
      Application WB(Detection kit: E-IR-R304),ELISA
      Recommended dilution WB 1:200-1:1000
      Concentration 0.2 mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Mitochondrion matrix.
      Isotype IgG
      Purification Affinity purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.05% sodium azide, 50% glycerol, PH7.3
      Background This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene.

      Images

      Western Blot analysis of Hela cell and Human liver cancer tissue using PC Polyclonal Antibody at dilution of 1:100

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