Phospho-CHEK2 (Thr383) Polyclonal Antibody

Uniprot : O96017
    • phospho antibody-Elabscience
    • phospho antibody-Elabscience
    • phospho antibody-Elabscience
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    >
    • phospho antibody-Elabscience
    • phospho antibody-Elabscience
    • phospho antibody-Elabscience
    • phospho antibody-Elabscience
    • phospho antibody-Elabscience
    • phospho antibody-Elabscience

      Catalog number:E-AB-21104

      Synonyms:CDS 1,Cds1,Cds1 homolog,Checkpoint kinase 2,Checkpoint like protein CHK2,CHEK 2,Chek2,Chk 2,CHK2 checkpoint homolog (S. pombe),CHK2 checkpoint homolog,CHK2,hCds1,HuCds 1,LFS 2,LFS2,PP1425,RAD 53,RAD53,Rad53 homolog,Serine/threonine protein kinase Chk2,Serine/threonine-protein kinase Chk2

      Size:
      • 20 μL
      • 60 μL
      • 120 μL
      • 200 μL
      Qty:
      - +
      Price: $69

      Host: Rabbit

      Reactivity: H,M,R,Mk

      Applications: WB,IF,ELISA

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms CDS 1,Cds1,Cds1 homolog,Checkpoint kinase 2,Checkpoint like protein CHK2,CHEK 2,Chek2,Chk 2,CHK2 checkpoint homolog (S. pombe),CHK2 checkpoint homolog,CHK2,hCds1,HuCds 1,LFS 2,LFS2,PP1425,RAD 53,RAD53,Rad53 homolog,Serine/threonine protein kinase Chk2,Serine/threonine-protein kinase Chk2
      Swissprot O96017
      Source Rabbit
      Reactivity Human,Mouse,Rat,Monkey
      Immunogen Synthesized peptide derived from human Chk2 around the phosphorylation site of Thr383
      Application WB(Detection kit: E-IR-R304),IF,ELISA
      Recommended dilution WB 1:500-1:2000, IF 1:100-1:300, ELISA 1:20000
      Concentration 1 mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Nucleus; Nucleus. Isoform 10 is present throughout the cell and Nucleus>PML body. Nucleus>nucleoplasm. Recruited into PML bodies together with TP53.
      Tissue specificity High expression is found in testis, spleen, colon and peripheral blood leukocytes. Low expression is found in other tissues.
      Isotype IgG
      Purification Affinity purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
      Background Regulates cell cycle checkpoints and apoptosis in response to DNA damage, particularly to DNA double-strand breaks. Inhibits CDC25C phosphatase by phosphorylation on 'Ser-216', preventing the entry into mitosis. May also play a role in meiosis. Regulates the TP53 tumor suppressor through phosphorylation at 'Thr-18' and 'Ser-20'.

      Images

      Western Blot analysis of Hela cells using Phospho-CHEK2 (Thr383) Polyclonal Antibody at dilution of 1:1000

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