PIM2 Polyclonal Antibody

Uniprot : Q9P1W9
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
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    >
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-14695

      Synonyms:OTTHUMP00000025825,Pim 2 oncogene,Pim 2h,Pim-2h,PIM2,PIM2 Oncogene,PIM2,Pim2h,Proto Oncogene PIM2,Proto-oncogene Pim-2 (serine threonine kinase),Serine/threonine kinase PIM2,Serine/threonine-protein kinase Pim-2

      Size:
      • 20μL
      • 60μL
      • 120μL
      • 200μL
      Qty:
      - +
      Price: $69

      Host: Rabbit

      Reactivity: H,M

      Applications: IHC,ELISA

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms OTTHUMP00000025825,Pim 2 oncogene,Pim 2h,Pim-2h,PIM2,PIM2 Oncogene,PIM2,Pim2h,Proto Oncogene PIM2,Proto-oncogene Pim-2 (serine threonine kinase),Serine/threonine kinase PIM2,Serine/threonine-protein kinase Pim-2
      Swissprot Q9P1W9
      Source Rabbit
      Reactivity Human,Mouse
      Immunogen Recombinant protein of human PIM2
      Application IHC(Detection kit: E-IR-R213),ELISA
      Recommended dilution IHC 1:25-1:100
      Concentration 0.2 mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Other locations:cytoplasm
      Tissue specificity Highly expressed in hematopoietic tissues, in leukemic and lymphoma cell lines, testis, small intestine, colon and colorectal adenocarcinoma cells. Weakly expressed in normal liver, but highly expressed in hepatocellular carcinoma tissues.
      Isotype IgG
      Purification Affinity purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.05% sodium azide and 50% glycerol, PH7.4
      Background This gene encodes a protooncogene that acts as a serine/threonine protein kinase. Studies determined the encoded protein functions to prevent apoptosis and to promote cell survival. Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of a pro-apoptotic protein, BAD. Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase transcriptional activity.

      Images

      Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PIM2 Polyclonal Antibody at dilution 1:30

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