PRKAR2A Polyclonal Antibody

Uniprot : P13861
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      Catalog number:E-AB-63707

      Synonyms:cAMP dependent protein kinase regulatory subunit alpha 2,cAMP dependent protein kinase regulatory subunit RII alpha,cAMP dependent protein kinase type II alpha regulatory chain,cAMP dependent protein kinase type II alpha regulatory subunit,cAMP-dependent protein kinase type II-alpha regulatory subunit,KAP2,KAP2,MGC3606,PKR 2,PKR2,PRKA R2,PRKAR 2,PRKAR2,PRKAR2A,Protein kinase A RII alpha subunit,Protein kinase cAMP dependent regulatory type II alpha

      Size:
      • 60μL
      • 120μL
      • 200μL
      Qty:
      - +
      Price: $129

      Host: Rabbit

      Reactivity: H,M,R

      Applications: WB

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms cAMP dependent protein kinase regulatory subunit alpha 2,cAMP dependent protein kinase regulatory subunit RII alpha,cAMP dependent protein kinase type II alpha regulatory chain,cAMP dependent protein kinase type II alpha regulatory subunit,cAMP-dependent protein kinase type II-alpha regulatory subunit,KAP2,KAP2,MGC3606,PKR 2,PKR2,PRKA R2,PRKAR 2,PRKAR2,PRKAR2A,Protein kinase A RII alpha subunit,Protein kinase cAMP dependent regulatory type II alpha
      Swissprot P13861
      Source Rabbit
      Reactivity Human,Mouse,Rat
      Immunogen Recombinant protein of human PRKAR2A
      Application WB(Detection kit: E-IR-R304)
      Recommended dilution WB 1:1000 - 1:2000
      Concentration 1mg/ml
      Clonality Polyclonal

      Properties

      Cellular localization Cytoplasm. Cell membrane. Colocalizes with PJA2 in the cytoplasm and the cell membrane.
      Tissue specificity Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.
      Isotype IgG
      Purification Affinity purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
      Background cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER).

      Images

      Western blot analysis of extracts of various cell lines with PRKAR2A Polyclonal Antibody

      Western blot analysis of extracts from normal (control) and PRKAR2A knockout (KO) HeLa cells, using PRKAR2A Polyclonal Antibody at dilution of 1:1000.

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