pVHL Polyclonal Antibody

Uniprot : P40337
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
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    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-14434

      Synonyms:Elongin binding protein,G7 protein,HRCA 1,HRCA1,Protein G7,pVHL,RCA 1,RCA1,VHL 1,VHL,VHL,VHL1,VHLH,Von Hippel Lindau disease tumor suppressor,von Hippel Lindau syndrome,von Hippel Lindau tumor suppressor,Von Hippel Lindau tumor suppressor,E3 ubiquitin protein ligase,Von Hippel-Lindau disease tumor suppressor

      Size:
      • 20μL
      • 60μL
      • 120μL
      • 200μL
      Qty:
      - +
      Price: $69

      Host: Rabbit

      Reactivity: H

      Applications: IHC,ELISA

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms Elongin binding protein,G7 protein,HRCA 1,HRCA1,Protein G7,pVHL,RCA 1,RCA1,VHL 1,VHL,VHL,VHL1,VHLH,Von Hippel Lindau disease tumor suppressor,von Hippel Lindau syndrome,von Hippel Lindau tumor suppressor,Von Hippel Lindau tumor suppressor,E3 ubiquitin protein ligase,Von Hippel-Lindau disease tumor suppressor
      Swissprot P40337
      Source Rabbit
      Reactivity Human
      Immunogen Recombinant protein of human VHL
      Application IHC(Detection kit: E-IR-R213),ELISA
      Recommended dilution IHC 1:25-1:100
      Concentration 0.3 mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Cytoplasm, Nucleus
      Tissue specificity Expressed in the adult and fetal brain and kidney.
      Isotype IgG
      Purification Affinity purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.05% sodium azide and 50% glycerol, PH7.4
      Background Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

      Images

      Immunohistochemistry of paraffin-embedded Human colon cancer tissue using pVHL Polyclonal Antibody at dilution 1:40

      Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using pVHL Polyclonal Antibody at dilution 1:40

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