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Rat IL-10(Interleukin 10) ELISA Kit

Citations(124)Uniprot : P29456

  • Cat.No.:E-EL-R0016

  • Reactivity: Rat
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Manual MSDS

To Purchase E-EL-R0016

Size:
  • 96T
  • 48T
  • 24T
  • 96T*5
  • 96T*10
Price: $495
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Product Details

Properties

Assay type Sandwich-ELISA
Format 96T/48T
Assay time 3.5h
Detection range 31.25-2000 pg/mL
Sensitivity 18.75 pg/mL
Sample type &Sample volume serum, plasma and other biological fluids; 100μL
Specificity This kit recognizes Rat IL-10 in samples. No significant cross-reactivity or interference between Rat IL-10 and analogues was observed.
Reproducibility Both intra-CV and inter-CV are < 10%.
Application This ELISA kit applies to the in vitro quantitative determination of Rat IL-10 concentrations in serum, plasma and other biological fluids.

Test Principle

This ELISA kit uses the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Rat IL-10. Standards or samples are added to the micro ELISA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for Rat IL-10 and Avidin-Horseradish Peroxidase (HRP) conjugate are added successively to each micro plate well and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Rat IL-10, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of stop solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm ± 2 nm. The OD value is proportional to the concentration of Rat IL-10. You can calculate the concentration of Rat IL-10 in the samples by comparing the OD of the samples to the standard curve.

Kit components & Storage

An unopened kit can be stored at 2-8℃ for 1 month. If the kit is not supposed to be used within 1 month, store the components separately according to the following conditions once the kit is received.
ItemSpecificationsStorage
Micro ELISA Plate(Dismountable) 96T: 8 wells ×12 strips
48T: 8 wells ×6 strips 		-20℃, 6 months
Reference Standard 96T: 2 vials
48T: 1 vial
Concentrated Biotinylated Detection Ab (100×) 96T: 1 vial, 120 μL
48T: 1 vial, 60 μL
Concentrated HRP Conjugate (100×) 96T: 1 vial, 120 μL
48T: 1 vial, 60 μL 		-20℃(Protect from light), 6 months
Reference Standard & Sample Diluent 1 vial, 20 mL 2-8°C, 6 months
Biotinylated Detection Ab Diluent 1 vial, 14 mL
HRP Conjugate Diluent 1 vial, 14 mL
Concentrated Wash Buffer (25×) 1 vial, 30 mL
Substrate Reagent 1 vial, 10 mL 2-8℃(Protect from light)
Stop Solution 1 vial, 10 mL 2-8°C
Plate Sealer 5 pieces
Manual 1 copy
Certificate of Analysis 1 copy

Technical Data

Precision

Intra-assay Precision (Precision within an assay): 3 samples with low, mid range and high level Rat IL-10 were tested 20 times on one plate, respectively.
Inter-assay Precision (Precision between assays): 3 samples with low, mid range and high level Rat IL-10 were tested on 3 different plates, 20 replicates in each plate.

  Intra-assay Precision Inter-assay Precision
Sample 1 2 3 1 2 3
n 20 20 20 20 20 20
Mean (pg/mL) 94.40 238.30 785.60 92.10 254.40 747.70
Standard deviation 5.90 13.60 23.60 5.20 14.50 32.90
CV (%) 6.25 5.71 3.00 5.65 5.70 4.40

Recovery

The recovery of Rat IL-10 spiked at three different levels in samples throughout the range of the assay was evaluated in various matrices.

Sample Type Range (%) Average Recovery (%)
Serum(n=8) 85-99 92
EDTA plasma (n=8) 93-104 98
Cell culture media (n=8) 92-105 98

Linearity

Samples were spiked with high concentrations of Rat IL-10 and diluted with Reference Standard & Sample Diluent to produce samples with values within the range of the assay.

Target Information

Database LinksSwissProt:   P29456
SynonymsIL10, IL10A, CSIF, TGIF
Research AreaCancer, Immunology

Assay Procedures

elisa assay procedure 1

1. Add 100μL standard or sample to the wells. Incubate for 90 min at 37°C
elisa assay procedure 2

2. Discard the liquid, immediately add 100μL Biotinylated Detection Ab working solution to each well. Incubate for 60 min at 37°C
elisa assay procedure 3

3. Aspirate and wash the plate for 3 times
elisa assay procedure 4

4. Add 100μL HRP conjugate working solution. Incubate for 30 min at 37°C. Aspirate and wash the plate for 5 times
elisa assay procedure 5

5. Add 90μL Substrate Reagent. Incubate for 15 min at 37°C
elisa assay procedure 6

6. Add 50μL Stop Solution
elisa assay procedure 7

7. Read the plate at 450nm immediately. Calculation of the results

Citations

  1. BIOMATERIALS (2022) IF: 15.304
    Immunology and bioinformatics analysis of injectable organic/inorganic microfluidic microspheres for promoting bone repair

    DOI: 10.1016/j.biomaterials.2022.121685

    PMID: 35953327

    		 Sample: BMSCs
  2. Advanced Healthcare Materials (2022) IF: 11.092
    Spatiotemporal regulation of the bone immune microenvironment via dam-like biphasic bionic periosteum for bone regeneration

    DOI: 10.1002/adhm.202201661

    PMID: 36189833

    		 Sample: BMSCs
  3. Advanced Healthcare Materials (2022) IF: 11.092
    An Acellular Scaffold Facilitates Endometrial Regeneration and Fertility Restoration via Recruiting Endogenous Mesenchymal Stem Cells

    DOI: 10.1002/adhm.202201680

    PMID: 36049781

    		 Sample: Uterine
  4. Acta Pharmaceutica Sinica B (2021) IF: 11.614
    Emodin attenuates severe acute pancreatitis-associated acute lung injury by suppressing pancreatic exosome-mediated alveolar macrophage activation

    DOI: 10.1016/j.apsb.2021.10.008

    PMID: 36213542

    		 Sample: serum
  5. JOURNAL OF NANOBIOTECHNOLOGY (2022) IF: 10.435
    A novel hierarchical biofunctionalized 3D-printed porous Ti6Al4V scaffold with enhanced osteoporotic osseointegration through osteoimmunomodulation

    DOI: 10.1186/s12951-022-01277-0

    PMID: 35123501

    		 Sample: rat bone marrow mesenchymal stem cells (rBMSCs)
  6. Stem Cell Research & Therapy (2022) IF: 8.0790
    Embryonic stem cell-derived mesenchymal stem cells alleviate skeletal muscle injury induced by acute compartment syndrome

    DOI: 10.1186/s13287-022-03000-0

    PMID: 35841081

    		 Sample: serum
  7. Journal of Neuroinflammation (2021) IF: 8.3219
    Rifaximin-mediated gut microbiota regulation modulates the function of microglia and protects against CUMS-induced depression-like behaviors in adolescent rat

    DOI: 10.1186/s12974-021-02303-y

    PMID: 34736493

    		 Sample: brain
  8. Acta Biomaterialia (2020) IF: 7.242
    A scaffold laden with mesenchymal stem cell-derived exosomes for promoting endometrium regeneration and fertility restoration through macrophage immunomodulation

    DOI: 10.1016/j.actbio.2020.06.029
    Sample: uteri
  9. Oxidative Medicine and Cellular Longevity (2022) IF: 7.31
    Sacubitril Valsartan Enhances Cardiac Function and Alleviates Myocardial Infarction in Rats through a SUV39H1/SPP1 Axis.

    DOI: 10.1155/2022/5009289
    Sample: cardiac tissue
  10. BIOMEDICINE & PHARMACOTHERAPY (2023) IF: 7.419
    Quince extract resists atherosclerosis in rats by down-regulating the EGFR/PI3K/Akt/GSK-3β pathway

    DOI: 10.1016/j.biopha.2023.114330
    Sample: serum
  11. Journal of Materials Chemistry B (2022) IF: 7.571
    Mesoporous hollow Fe3O4 nanoparticles regulate the behavior of neuro-associated cells through induction of macrophages polarization in an alternating magnetic field

    DOI: 10.1039/D2TB00527A
    Sample: RAw 264.7 cell
  12. PHARMACOLOGICAL RESEARCH (2022) IF: 7.658
    Biomimetic micelles to accurately regulate the inflammatory microenvironment for glomerulonephritis treatment

    DOI: 10.1016/j.phrs.2022.106263
    Sample: kidney
  13. JOURNAL OF PINEAL RESEARCH (2014) IF: 7.812
    Melatonin normalizes clinical and biochemical parameters of mild inflammation in diet‐induced metabolic syndrome in rats

    DOI: 10.1111/jpi.12168
    Sample: Plasma
  14. Frontiers in Cellular and Infection Microbiology (2022) IF: 6.073
    Liujunanwei decoction attenuates cisplatin-induced nausea and vomiting in a Rat-Pica model partially mediated by modulating the gut micsrobiome

    DOI: 10.3389/fcimb.2022.876781

    PMID: 36061858

    		 Sample: jejunum tissue,medulla oblongata tissue
  15. BIOMEDICINE & PHARMACOTHERAPY (2018) IF: 6.53
    Trichosanthes kirilowii lectin ameliorates streptozocin-induced kidney injury via modulation of the balance between M1/M2 phenotype macrophage

    DOI: 10.1016/j.biopha.2018.10.060

    PMID: 30396096

    		 Sample: Serum
  16. Oxidative Medicine and Cellular Longevity (2022) IF: 6.543
    Potential Therapeutic Effects of Mi-Jian-Chang-Pu Decoction on Neurochemical and Metabolic Changes of Cerebral Ischemia-Reperfusion Injury in Rats

    DOI: 10.1155/2022/7319563

    PMID: 35578728

    		 Sample: brain
  17. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021) IF: 6.953
    Lycium barbarum polysaccharide combined with aerobic exercise ameliorated nonalcoholic fatty liver disease through restoring gut microbiota, intestinal barrier and inhibiting hepatic inflammation

    DOI: 10.1016/j.ijbiomac.2021.05.066

    PMID: 33992651

    		 Sample: Tissue homogenate(Liver)
  18. LIFE SCIENCES (2022) IF: 5.037
    Angiotensin 1–7 mitigates rhabdomyolysis induced renal injury in rats via modulation of TLR-4/NF-kB/iNOS and Nrf-2/heme‑oxygenase-1 signaling pathways

    DOI: 10.1016/j.lfs.2022.120678
    Sample: Kidney
  19. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2022) IF: 5.112
    Thermosensitive smart hydrogel of PEITC ameliorates the therapeutic efficacy in rheumatoid arthritis

    DOI: 10.1016/j.ejps.2022.106367
    Sample: serum
  20. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2023) IF: 5.19
    Betulinic acid protects against cardiotoxicity of the organophosphorus pesticide chlorpyrifos by suppressing oxidative stress, inflammation, and apoptosis in rats

    DOI: 10.1007/s11356-023-25917-6
    Sample: heart
  21. CHEMICO-BIOLOGICAL INTERACTIONS (2021) IF: 5.194
    Targeting inflammation and redox aberrations by perindopril attenuates methotrexate-induced intestinal injury in rats: Role of TLR4/NF-κB and c-Fos/c-Jun pro-inflammatory pathways and PPAR-γ/SIRT1 cytoprotective signals

    DOI: 10.1016/j.cbi.2021.109732

    PMID: 34737150

    		 Sample: serum
  22. JOURNAL OF ETHNOPHARMACOLOGY (2022) IF: 5.195
    Exploring the anti-inflammatory potential of Colocasia esculenta root extract in in-vitro and in-vivo models of inflammation

    DOI: 10.1016/j.jep.2022.116021
    Sample: serum
  23. Pharmaceuticals (2022) IF: 5.215
    Azithromycin Mitigates Cisplatin-Induced Lung Oxidative Stress, Inflammation and Necroptosis by Upregulating SIRT1, PPARγ, and Nrf2/HO-1 Signaling

    DOI: 10.3390/ph16010052
    Sample: lungs
  24. Frontiers in Cellular and Infection Microbiology (2022) IF: 5.293
    Intestinal Epithelial Cell Exosome Launches IL-1β-Mediated Neuron Injury in Sepsis-Associated Encephalopathy

    DOI: 10.3389/fcimb.2021.783049

    PMID: 35111693

    		 Sample: serum,hippocampal tissue
  25. Food & Function (2021) IF: 5.396
    Dry heated sorghum BRS 305 hybrid flour as a source of resistant starch and tannins improves inflammation and oxidative stress in Wistar rats fed with a high-fat high-fructose diet

    DOI: 10.1039/D1FO00802A

    PMID: 34369542

    		 Sample: liver
  26. Chinese Medicine (2022) IF: 5.455
    Combination of pseudoephedrine and emodin ameliorates LPS-induced acute lung injury by regulating macrophage M1/M2 polarization through the VIP/cAMP/PKA pathway

    DOI: 10.1186/s13020-021-00562-8

    PMID: 35123524

    		 Sample: serum
  27. Metabolites (2022) IF: 5.581
    Curcumin and Vitamin C Attenuate Gentamicin-Induced Nephrotoxicity by Modulating Distinctive Reactive Species

    DOI: 10.3390/metabo13010049
    Sample: serum
  28. MOLECULAR NEUROBIOLOGY (2022) IF: 5.682
    Activation of Angiotensin-converting Enzyme 2 Protects Against Lipopolysaccharide-induced Glial Activation by Modulating Angiotensin-converting Enzyme 2/Angiotensin (1–7)/Mas Receptor Axis

    DOI: 10.1007/s12035-022-03061-5
    Sample: cortex,hippocampus,C6 cell
  29. Frontiers in Pharmacology (2021) IF: 5.811
    β-Patchoulene Ameliorates Water Transport and the Mucus Barrier in 5-Fluorouracil-Induced Intestinal Mucositis Rats via the cAMP/PKA/CREB Signaling Pathway

    DOI: 10.3389/fphar.2021.689491
    Sample: Intestinal
  30. Frontiers in Pharmacology (2022) IF: 5.988
    Tormentic Acid Ameliorates Hepatic Fibrosis in vivo by Inhibiting Glycerophospholipids Metabolism and PI3K/Akt/mTOR and NF-κB Pathways: Based on Transcriptomics and Metabolomics.

    DOI: 10.3389/fphar.2022.801982
    Sample: hepatic tissue
  31. BRAIN RESEARCH BULLETIN (2022) IF: 4.079
    Win55,212-2 Improves Neural Injury induced by HIV-1 Glycoprotein 120 in Rats by Exciting CB2R

    DOI: 10.1016/j.brainresbull.2022.02.006

    PMID: 35157986

    		 Sample: hippocampus
  32. JOURNAL OF CELLULAR PHYSIOLOGY (2017) IF: 4.08
    MSCs ameliorates DPN induced cellular pathology via [Ca2+]i homeostasis and scavenging the pro‐inflammatory cytokines

    DOI: 10.1002/jcp.26009
    Sample: neuronal cell
  33. TOXICOLOGY (2020) IF: 4.099
    Protocatechuic acid modulates reproductive dysfunction linked to furan exposure in rats

    DOI: 10.1016/j.tox.2020.152556

    PMID: 32758512

    		 Sample: Serum,Tissue homogenate
  34. ENVIRONMENTAL TOXICOLOGY (2022) IF: 4.109
    hUC-MSCs exosomal miR-451 alleviated acute lung injury by modulating macrophage M2 polarization via regulating MIF-PI3K-AKT signaling pathway

    DOI: 10.1002/tox.23639
    Sample: serum,NR8383 cell
  35. ENVIRONMENTAL TOXICOLOGY (2022) IF: 4.119
    LncRNA MEG3 ameliorates NiO nanoparticles-induced pulmonary inflammatory damage via suppressing the p38 mitogen activated protein kinases pathway

    DOI: 10.1002/tox.23464

    PMID: 35006638

    		 Sample: bronchoalveolar lavage fluid (BALF)
  36. ENVIRONMENTAL TOXICOLOGY (2021) IF: 4.119
    Imbalanced inflammatory response in subchronic arsenic-induced liver injury and the protective effects of Ginkgo biloba extract in rats: Potential role of cytokines mediated cell–cell interactions

    DOI: 10.1002/tox.23324
    Sample: serum,liver
  37. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019) IF: 4.183
    Deep-Fried Atractylodis Rhizoma Protects against Spleen Deficiency-Induced Diarrhea through Regulating Intestinal Inflammatory Response and Gut Microbiota

    DOI: 10.3390/ijms21010124
    Sample: serum
  38. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2022) IF: 4.223
    3-Indolepropionic acid prevented chlorpyrifos-induced hepatorenal toxicities in rats by improving anti-inflammatory, antioxidant, and pro-apoptotic responses and abating DNA damage

    DOI: 10.1007/s11356-022-21075-3

    PMID: 35644820

    		 Sample: Hepatic,renal
  39. Scientific Reports (2017) IF: 4.259
    Hydrogen sulfide ameliorates chronic renal failure in rats by inhibiting apoptosis and inflammation through ROS/MAPK and NF- κ B signaling pathways

    DOI: 10.1038/s41598-017-00557-2
    Sample: Tissue homogenate
  40. Scientific Reports (2017) IF: 4.259
    Effect of Niacin on Inflammation and Angiogenesis in a Murine Model of Ulcerative Colitis

    DOI: 10.1038/s41598-017-07280-y
    Sample: Tissue homogenate
  41. Foods (2022) IF: 4.35
    Chia (Salvia hispanica L.) Flour and Oil Ameliorate Metabolic Disorders in the Liver of Rats Fed a High-Fat and High Fructose Diet

    DOI: 10.3390/foods11030285
    Sample: liver tissue
  42. JOURNAL OF ETHNOPHARMACOLOGY (2021) IF: 4.36
    Role of Glutamine-Glutamate/GABA cycle and potential target GLUD2 in alleviation of rheumatoid arthritis by Tripterygium hypoglaucum (levl.) Hutch based on metabolomics and molecular pharmacology

    DOI: 10.1016/j.jep.2021.114561

    PMID: 34454056

    		 Sample: serum
  43. JOURNAL OF ETHNOPHARMACOLOGY (2021) IF: 4.36
    Aloe vera mitigates dextran sulfate sodium-induced rat ulcerative colitis by potentiating colon mucus barrier

    DOI: 10.1016/j.jep.2021.114108

    PMID: 33839199

    		 Sample: Tissue homogenate
  44. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2022) IF: 4.369
    BMSC-EVs overexpressing PD-L1 ameliorate DSS-induced ulcerative colitis in rats by regulating Th17/Treg cell balance through PTEN/PI3K/AKT/mTOR axis

    DOI: 10.1111/jgh.15987
    Sample: blood,colon
  45. Scientific Reports (2021) IF: 4.38
    Mothers’ cafeteria diet induced sex-specific changes in fat content, metabolic profiles, and inflammation outcomes in rat offspring

    DOI: 10.1038/s41598-021-97487-x
    Sample: serum
  46. MOLECULAR PHARMACEUTICS (2019) IF: 4.396
    Accelerated Blood Clearance of Nanoemulsions Modified with PEG-Cholesterol and PEG-Phospholipid Derivatives in Rats: The Effect of PEG-Lipid Linkages and PEG Molecular Weights

    DOI: 10.1021/acs.molpharmaceut.9b00770

    PMID: 31860321

    		 Sample: Serum
  47. NEUROCHEMICAL RESEARCH (2022) IF: 4.414
    Stellate Ganglion Block Improves Postoperative Cognitive Dysfunction in aged rats by SIRT1-mediated White Matter Lesion Repair

    DOI: 10.1007/s11064-022-03800-z

    PMID: 36315371

    		 Sample: serum,white matter samples
  48. INFLAMMOPHARMACOLOGY (2021) IF: 4.473
    Exploring the role of Aquaporins (AQPs) in LPS induced systemic inflammation and the ameliorative effect of Garcinia in male Wistar rat

    DOI: 10.1007/s10787-021-00832-9

    PMID: 34106384

    		 Sample: serum
  49. JOURNAL OF CELLULAR PHYSIOLOGY (2019) IF: 4.522
    C1q/TNF‐related protein‐9 promotes macrophage polarization and improves cardiac dysfunction after myocardial infarction

    DOI: 10.1002/jcp.28513
    Sample: Tissue homogenate
  50. Frontiers in Physiology (2021) IF: 4.566
    Chronic Intermittent Hypobaric Hypoxia Decreases High Blood Pressure by Stabilizing the Vascular Renin-Angiotensin System in Spontaneously Hypertensive Rats

    DOI: 10.3389/fphys.2021.639454
    Sample: serum
  51. MEDIATORS OF INFLAMMATION (2020) IF: 4.711
    Exploring the Mechanism on the Medullary Visceral Zone Inhibiting the Cholinergic Anti-inflammatory Pathway Induced by Sepsis

    DOI: 10.1155/2020/1320278

    PMID: 33061821

    		 Sample: Serum
  52. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019) IF: 4.784
    Anti-inflammatory effect of epidermal growth factor conjugated silk fibroin immobilized polyurethane ameliorates diabetic burn wound healing

    DOI: 10.1016/j.ijbiomac.2019.09.219

    PMID: 31647938

    		 Sample: Serum,Tissue homogenate
  53. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (2021) IF: 4.86
    N-acetyl cysteine abates hepatorenal toxicities induced by perfluorooctanoic acid exposure in male rats

    DOI: 10.1016/j.etap.2021.103667

    PMID: 33933708

    		 Sample: Serum,Tissue homogenate
  54. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (2021) IF: 4.86
    Indole-3-propionic acid mitigates chlorpyrifos-mediated neurotoxicity by modulating cholinergic and redox-regulatory systems, inflammatory stress, apoptotic responses and DNA damage in rats

    DOI: 10.1016/j.etap.2021.103786

    PMID: 34915193

    		 Sample: brain
  55. MOLECULES (2022) IF: 4.927
    Effect of Natural Adenylcyclase/cAMP/CREB Signalling Activator Forskolin against Intra-Striatal 6-OHDA-Lesioned Parkinson’s Rats: Preventing Mitochondrial, Motor and Histopathological Defects

    DOI: 10.3390/molecules27227951
    Sample: brain
  56. Oxidative Medicine and Cellular Longevity (2018) IF: 4.936
    Hydrogen Sulfide Alleviates Lipopolysaccharide-Induced Diaphragm Dysfunction in Rats by Reducing Apoptosis and Inflammation through ROS/MAPK and TLR4/NF-κB Signaling Pathways

    DOI: 10.1155/2018/9647809
    Sample: Cells
  57. European Review for Medical and Pharmacological Sciences (2020) IF: 3.024
    The effect of myocardial infarction-associated transcript 2 (Mirt2) and miR-101 on sepsis-induced myocardial injury in rats.

    DOI: 10.26355/eurrev_202006_21528
    Sample: Serum
  58. TOXICON (2022) IF: 3.033
    Caffeic acid protects against DNA damage, oxidative and inflammatory mediated toxicities, and upregulated caspases activation in the hepatorenal system of rats treated with aflatoxin B1

    DOI: 10.1016/j.toxicon.2021.12.021

    PMID: 34995555

    		 Sample: liver,kidney
  59. PeerJ (2022) IF: 3.061
    Effects of combination of obesity, diabetes, and hypoxia on inflammatory regulating genes and cytokines in rat pancreatic tissues and serum

    DOI: 10.7717/peerj.13990

    PMID: 36213511

    		 Sample: serum
  60. AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2019) IF: 3.091
    Nisin reduces uterine inflammation in rats by modulating concentrations of pro‐ and anti‐inflammatory cytokines

    DOI: 10.1111/aji.13096
    Sample: Serum
  61. EUROPEAN JOURNAL OF PHARMACOLOGY (2019) IF: 3.17
    Therapeutic effect of treatment with metformin and/or 4-hydroxychalcone in male Wistar rats with nonalcoholic fatty liver disease

    DOI: 10.1016/j.ejphar.2019.172699
    Sample: serum
  62. Drug Design Development and Therapy (2020) IF: 3.216
    KGF Is Delivered to Inflammatory and Induces the Epithelial Hyperplasia in Trinitrobenzene Sulfonic Acid-Induced Ulcerative Colitis Rats

    DOI: 10.2147/DDDT.S227651
    Sample: intestinal tissue
  63. PLoS One (2015) IF: 3.234
    Transplantation of Induced Pluripotent Stem Cells Alleviates Cerebral Inflammation and Neural Damage in Hemorrhagic Stroke

    DOI: 10.1371/journal.pone.0129881
    Sample: Tissue homogenate
  64. PLoS One (2015) IF: 3.234
    Extracellular Vesicles Derived from Bone Marrow Mesenchymal Stem Cells Protect against Experimental Colitis via Attenuating Colon Inflammation, Oxidative Stress and Apoptosis

    DOI: 10.1371/journal.pone.0140551
    Sample: Tissue homogenate
  65. EUROPEAN JOURNAL OF PHARMACOLOGY (2020) IF: 3.263
    Gastrodin alleviates perioperative neurocognitive dysfunction of aged mice by suppressing neuroinflammation

    DOI: 10.1016/j.ejphar.2020.173734

    PMID: 33220272

    		 Sample: Tissue homogenate(Hippocampal tissues)
  66. TOXICOLOGY AND APPLIED PHARMACOLOGY (2020) IF: 3.347
    Co-administration of Luteolin mitigated toxicity in rats' lungs associated with doxorubicin treatment

    DOI: 10.1016/j.taap.2020.115380

    PMID: 33358696

    		 Sample: Tissue homogenate
  67. International Journal of Chronic Obstructive Pulmonary Disease (2022) IF: 3.355
    The Bufei Jianpi Formula Improves Mucosal Immune Function by Remodeling Gut Microbiota Through the SCFAs/GPR43/NLRP3 Pathway in Chronic Obstructive Pulmonary Disease Rats

    DOI: 10.2147/COPD.S359428

    PMID: 35673595

    		 Sample: lung tissue
  68. DRUG AND CHEMICAL TOXICOLOGY (2021) IF: 3.356
    Rupatadine protects the intestinal mucosa from injury by 5-flurouracil via modulation of inflammation, apoptosis and intestinal permeability

    DOI: 10.1080/01480545.2021.1997541

    PMID: 34747284

    		 Sample: intestinal
  69. Biomed Research International (2021) IF: 3.411
    Celastrol Attenuates Learning and Memory Deficits in an Alzheimer’s Disease Rat Model

    DOI: 10.1155/2021/5574207
    Sample: brain
  70. Molecular Medicine Reports (2022) IF: 3.423
    Adipose‑derived mesenchymal stem cell‑derived HCAR1 regulates immune response in the attenuation of sepsis

    DOI: 10.3892/mmr.2022.12795

    PMID: 35856408

    		 Sample: blood
  71. JOURNAL OF CELLULAR BIOCHEMISTRY (2019) IF: 3.448
    Evodiamine alleviates kidney ischemia reperfusion injury in rats: A biochemical and histopathological study

    DOI: 10.1002/jcb.28976

    PMID: 31099131

    		 Sample: Tissue homogenate
  72. DISEASE MARKERS (2022) IF: 3.464
    Estrogen Protects against Renal Ischemia-Reperfusion Injury by Regulating Th17/Treg Cell Immune Balance

    DOI: 10.1155/2022/7812099

    PMID: 36246554

    		 Sample: serum,kidney tissues
  73. JOURNAL OF NEUROIMMUNOLOGY (2022) IF: 3.478
    Activation of TRESK background potassium channels by cloxyquin exerts protective effects against excitotoxic-induced brain injury and neuroinflammation in neonatal rats

    DOI: 10.1016/j.jneuroim.2022.577894

    PMID: 35642994

    		 Sample: Brain tissue
  74. European Review for Medical and Pharmacological Sciences (2018) IF: 3.507
    Renal ischemia-reperfusion injury attenuated by splenic ischemic preconditioning.

    DOI: 10.26355/eurrev_201804_14747
    Sample: serum
  75. Toxicology Research (2021) IF: 3.524
    The modulatory effect of taurine on benzo (a) pyrene-induced hepatorenal toxicity

    DOI: 10.1093/toxres/tfab016

    PMID: 34141152

    		 Sample: serum
  76. Toxicology Research (2021) IF: 3.524
    Chlorogenic acid abates oxido-inflammatory and apoptotic responses in the liver and kidney of Tamoxifen-treated rats

    DOI: 10.1093/toxres/tfab002
    Sample: hepatic,renal
  77. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021) IF: 3.575
    Effects of hydroxysafflor yellow A on rats with collagen-induced arthritis

    DOI: 10.1016/j.bbrc.2021.07.026

    PMID: 34271433

    		 Sample: serum
  78. NEUROSCIENCE (2022) IF: 3.59
    High Environmental Temperature: Insights into Behavioural, Neurodevelopmental and Gut Microbiome Changes Following Gestational Exposure in Rats

    DOI: 10.1016/j.neuroscience.2022.02.026

    PMID: 35231581

    		 Sample: Brain
  79. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2020) IF: 3.606
    Neuroprotective role of gallic acid in aflatoxin B1‐induced behavioral abnormalities in rats

    DOI: 10.1002/jbt.22684
    Sample: cerebrum tissue lysate supernatant
  80. JOURNAL OF CEREAL SCIENCE (2021) IF: 3.616
    Germinated millet flour (Pennisetum glaucum (L.) R. Br.) reduces inflammation, oxidative stress, and liver steatosis in rats fed with high-fat high-fructose diet

    DOI: 10.1016/j.jcs.2021.103207
    Sample: Blood
  81. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2021) IF: 3.652
    Biochemical and histological alterations of doxorubicin-induced neurotoxicity in rats: Protective role of luteolin

    DOI: 10.1002/jbt.22962

    PMID: 34766659

    		 Sample: brain
  82. Journal of Functional Foods (2020) IF: 3.701
    Regulation of inflammatory response and oxidative stress by tocotrienol in a rat model of non-alcoholic fatty liver disease

    DOI: 10.1016/j.jff.2020.104209
    Sample: serum and liver
  83. BIOLOGICAL TRACE ELEMENT RESEARCH (2022) IF: 3.738
    Candesartan Protects Against Cadmium-Induced Hepatorenal Syndrome by Affecting Nrf2, NF-κB, Bax/Bcl-2/Cyt-C, and Ang II/Ang 1–7 Signals

    DOI: 10.1007/s12011-022-03286-4
    Sample: kidney
  84. CERAMICS INTERNATIONAL (2020) IF: 3.83
    Synthesis and characterization of barium-doped bioactive glass with potential anti-inflammatory activity

    DOI: 10.1016/j.ceramint.2020.11.068
    Sample: Cell culture supernatant
  85. Frontiers in Pharmacology (2019) IF: 3.845
    Docosahexaenoic Acid Increases the Potency of Soluble Epoxide Hydrolase Inhibitor in Alleviating Streptozotocin-Induced Alzheimer’s Disease-Like Complications of Diabetes

    DOI: 10.3389/fphar.2019.00288
    Sample: hippocampus tissues
  86. PEPTIDES (2023) IF: 3.867
    Irisin prevents hypoxic-ischemic brain damage in rats by inhibiting oxidative stress and protecting the blood-brain barrier

    DOI: 10.1016/j.peptides.2023.170945
    Sample: brain
  87. REPRODUCTION (2021) IF: 3.906
    Melatonin ameliorates ovarian dysfunction by regulating autophagy in PCOS via the PI3K-Akt pathway

    DOI: 10.1530/REP-20-0643

    PMID: 33989172

    		 Sample: Ovary
  88. Annals of Translational Medicine (2021) IF: 3.932
    Conjugated linoleic acid prompts bone formation in ovariectomized osteoporotic rats and weakens osteoclast formation after treatment with ultraviolet B

    DOI: 10.21037/atm-21-934

    PMID: 33850900

    		 Sample: Serum
  89. INTERNATIONAL IMMUNOPHARMACOLOGY (2020) IF: 3.943
    The fatty acid amide hydrolase inhibitor URB597 modulates splenic catecholamines in chronically stressed female and male rats

    DOI: 10.1016/j.intimp.2020.106615

    PMID: 32447219

    		 Sample: Plasma
  90. IMMUNOLOGY AND CELL BIOLOGY (2019) IF: 3.947
    Effects of IL‐10‐ and FasL‐overexpressing dendritic cells on liver transplantation tolerance in a heterotopic liver transplantation rat model

    DOI: 10.1111/imcb.12252
    Sample: Cell culture supernatant
  91. Iranian Journal of Basic Medical Sciences (2020) IF: 2.146
    Effect of doxycycline and meloxicam on cytokines, brain-derived neurotrophic factor, matrix metalloproteinase-3, tissue inhibitor of metalloproteinase-3 and cyclooxygenase-2 in brain

    DOI: 10.22038/ijbms.2020.45193.10527

    PMID: 33149866

    		 Sample: Tissue homogenate
  92. Open Medicine (2022) IF: 2.199
    Lidocaine ameliorates chronic constriction injury-induced neuropathic pain through regulating M1/M2 microglia polarization

    DOI: 10.1515/med-2022-0480
    Sample: HAPI cell
  93. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2017) IF: 2.341
    SIRT1 exerts neuroprotective effects by attenuating cerebral ischemia/reperfusion-induced injury via targeting p53/microRNA-22

    DOI: 10.3892/ijmm.2016.2806
    Sample: Tissue homogenate
  94. PeerJ (2019) IF: 2.353
    Effect of heat-killed Streptococcus thermophilus on type 2 diabetes rats

    DOI: 10.7717/peerj.7117
    Sample: serum
  95. Journal of Integrative Medicine-JIM (2020) IF: 2.446
    Effects of co-administration of Ganoderma terpenoid extract with chloroquine on inflammatory markers and antioxidant status in Plasmodium berghei-infected mice

    DOI: 10.1016/j.joim.2020.08.002
    Sample: serum
  96. Experimental and Therapeutic Medicine (2019) IF: 2.447
    H2S attenuates sepsis‑induced cardiac dysfunction via a PI3K/Akt‑dependent mechanism

    DOI: 10.3892/etm.2019.7440
    Sample: serum
  97. Experimental and Therapeutic Medicine (2021) IF: 2.447
    Accelerated lipid peroxidation in a rat model of gentamicin nephrotoxicity

    DOI: 10.3892/etm.2021.10652

    PMID: 34584563

    		 Sample: serum
  98. BMC Pharmacology & Toxicology (2022) IF: 2.605
    Accidental lead in contaminated pipe-borne water and dietary furan intake perturbs rats’ hepatorenal function altering oxidative, inflammatory, and apoptotic balance

    DOI: 10.1186/s40360-022-00615-0
    Sample: hepatic,renal
  99. BIOMARKERS (2022) IF: 2.663
    Justicia carnea extracts ameliorated hepatocellular damage in streptozotocin-induced type 1 diabetic male rats via decrease in oxidative stress, inflammation and increasing other risk markers

    DOI: 10.1080/1354750X.2022.2157487
    Sample: liver
  100. JOURNAL OF FOOD BIOCHEMISTRY (2022) IF: 2.72
    Effect of coconut water and milk on heat stress-induced gastrointestinal tract dysmotility in rats: Role of oxidative stress and inflammatory response

    DOI: 10.1111/jfbc.14129

    PMID: 35298033

    		 Sample: stomach
  101. JOURNAL OF FOOD BIOCHEMISTRY (2021) IF: 2.72
    Chlorogenic acid co-administration abates tamoxifen-mediated reproductive toxicities in male rats: An experimental approach

    DOI: 10.1111/jfbc.13615

    PMID: 33491243

    		 Sample: Tissue homogenate
  102. Pharmacological Reports (2020) IF: 2.754
    Agomelatine prevents indomethacin-induced gastric ulcer in rats

    DOI: 10.1007/s43440-019-00049-2
    Sample: gastric tissue
  103. PHYSIOLOGY & BEHAVIOR (2020) IF: 2.826
    Inhibition of the fatty acid amide hydrolase changes behaviors and brain catecholamines in a sex-specific manner in rats exposed to chronic unpredictable stress

    DOI: 10.1016/j.physbeh.2020.113174

    PMID: 32966816

    		 Sample: Tissue homogenate
  104. VIRUS RESEARCH (2014) IF: 2.827
    Galectin-9 ameliorates respiratory syncytial virus-induced pulmonary immunopathology through regulating the balance between Th17 and regulatory T cells

    DOI: 10.1016/j.virusres.2014.10.011
    Sample: Tissue homogenate
  105. WOUND REPAIR AND REGENERATION (2019) IF: 2.85
    Effects of depression on healing and inflammatory responses of acute wounds in rats

    DOI: 10.1111/wrr.12726
    Sample: serum
  106. CELL STRESS & CHAPERONES (2020) IF: 2.892
    Hydrogen sulfide renal protective effects: possible link between hydrogen sulfide and endogenous carbon monoxide in a rat model of renal injury

    DOI: 10.1007/s12192-019-01055-2

    PMID: 32088905

    		 Sample: Tissue homogenate
  107. EUROPEAN JOURNAL OF PHARMACOLOGY (2017) IF: 2.896
    Vinpocetine mitigates proteinuria and podocytes injury in a rat model of diabetic nephropathy

    DOI: 10.1016/j.ejphar.2017.08.027
    Sample: Serum
  108. HUMAN & EXPERIMENTAL TOXICOLOGY (2021) IF: 2.903
    Luteolin attenuates doxorubicin-induced derangements of liver and kidney by reducing oxidative and inflammatory stress to suppress apoptosis:

    DOI: 10.1177/09603271211006171
    Sample: Tissue homogenate
  109. Future Microbiology (2020) IF: 2.907
    The anti-inflammatory, anti-oxidant and protective effects of a probiotic mixture on organ toxicity in a rat model

    DOI: 10.2217/fmb-2020-0005

    PMID: 32250184

    		 Sample: Serum
  110. JOURNAL OF CELLULAR BIOCHEMISTRY (2018) IF: 2.959
    Extracts of Coleus forskohlii relieves cough and asthma symptoms via modulating inflammation and the extracellular matrix

    DOI: 10.1002/jcb.28243

    PMID: 30520122

    		 Sample: Serum,Bronchoalveolar Lavage Fluid
  111. BIOLOGY OF REPRODUCTION (2019) IF: 2.96
    Changes in alpha-7 nicotinic acetylcholine receptor and macrophage polarization state participate in the regulation of cervical remodeling in pregnant rats

    DOI: 10.1093/biolre/ioz133
    Sample: Tissue homogenate
  112. Cardiovascular Toxicology (2018) IF: 2.989
    Anti-fibrotic Actions of Roselle Extract in Rat Model of Myocardial Infarction

    DOI: 10.1007/s12012-018-9478-7
    Sample: plasma
  113. CONTRIBUTIONS TO PLASMA PHYSICS (2018) IF: 1.318
    Effects and mechanisms of cold atmospheric plasma on skin wound healing of rats

    DOI: 10.1002/ctpp.201800025
    Sample: skin tissues
  114. Experimental and Therapeutic Medicine (2018) IF: 1.41
    Gambogic acid exerts cardioprotective effects in a rat model of acute myocardial infarction through inhibition of inflammation, iNOS and NF‑κB/p38 pathway

    DOI: 10.3892/etm.2017.5599
    Sample: Serum
  115. IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY (2016) IF: 1.617
    Anti-oxidant and anti-inflammatory effects of apigenin in a rat model of sepsis: an immunological, biochemical, and histopathological study

    DOI: 10.3109/08923973.2016.1173058
    Sample: Serum
  116. JOURNAL OF FOOD BIOCHEMISTRY (2020) IF: 1.662
    The effects of chrysin on lipopolysaccharide‐induced sepsis in rats

    DOI: 10.1111/jfbc.13359
    Sample: lung,liver,kidney
  117. Food Science & Nutrition (2020) IF: 1.797
    Protective effect of Alpinetin on rats with chronic obstructive pulmonary disease

    DOI: 10.1002/fsn3.1952

    PMID: 33312544

    		 Sample: Cell culture supernatant
  118. Cutaneous and Ocular Toxicology (2021) IF: 1.82
    Effects of Achillea millefolium on cisplatin induced ocular toxicity: an experimental study

    DOI: 10.1080/15569527.2021.1919137

    PMID: 34180746

    		 Sample: ocular
  119. International Journal of Endocrinology (2015) IF: 1.948
    17β Estradiol Modulates Perfusion Pressure and Expression of 5-LOX and CYP450 4A in the Isolated Kidney of Metabolic Syndrome Female Rats

    DOI: 10.1155/2015/149408
    Sample: Tissue homogenate
  120. Toxicology Research (2017) IF: 1.969
    Nano NiO induced liver toxicity via activating the NF-κB signaling pathway in rats

    DOI: 10.1039/C6TX00444J
    Sample: Tissue homogenate
  121. Advances in Traditional Medicine (2023)
    Amaranthus spinosus (Spiny Pigweed) methanol leaf extract alleviates oxidative and inflammation induced by doxorubicin in male sprague dawley rats

    DOI: 10.1007/s13596-022-00677-9
    Sample: serum
  122. Scientific African (2022)
    Allium vineale methanol extract attenuated oxidative stress and inflammation induced by doxorubicin in Sprague Dawley Rats

    DOI: 10.1016/j.sciaf.2022.e01244
    Sample: serum
  123. International Journal of Clinical and Experimental Pathology (2020) IF: 0.252
    Sepsis causes heart injury through endoplasmic reticulum stress-mediated apoptosis signaling pathway

    PMID: 32509067

    		 Sample: serum
  124. Ulusal Travma ve Acil Cerrahi Dergisi-Turkish Journal of Trauma & Emergency Surgery (2022) IF: 0.894
    Intraductal botulinum toxin injection suppressed the inflammation in experimental acute pancreatitis.

    DOI: 10.14744/tjtes.2021.90140
    Sample: Serum
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