Recombinant 2019-nCoV Helicase Protein (His Tag)

    • Recombinant Rat Alpha-fetoprotein Protein (His Tag)-Elabscience
    • Recombinant 2019-nCoV Helicase Protein (His Tag)-Elabscience
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    • Recombinant Rat Alpha-fetoprotein Protein (His Tag)-Elabscience
    • Recombinant 2019-nCoV Helicase Protein (His Tag)-Elabscience
    • Recombinant Rat Alpha-fetoprotein Protein (His Tag)-Elabscience
    • Recombinant 2019-nCoV Helicase Protein (His Tag)-Elabscience

      Catalog number:PKSR030466

      Synonyms:SARS-CoV 2 Helicase; SARS-CoV 2 nsp13

      Size:
      • 10µg
      • 50µg
      Qty:
      - +
      Price: $220

      Lead Time: Order now, ship in 3 daysWelcome to order from local distributors.

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      Overview

      Synonyms SARS-CoV 2 Helicase; SARS-CoV 2 nsp13
      Species Virus
      Expression_host E.coli
      Sequence Ala1-Gln601
      Accession YP_009725308.1
      Mol_Mass 70 kDa
      AP_Mol_Mass 70 kDa
      Tag C-6His

      Properties

      Purity > 90 % as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per µg as determined by the LAL method.
      Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
      Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt; store it immediately at<-20°C.
      Formulation Supplied as a 0.2 μM filtered solution of PBS, 10% Glycerol, pH 7.4.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      The non-structural protein 13 (nsp13) of 2019-nCoV is a helicase that separates double-stranded RNA or DNA with a 5'-3' polarity, using the energy of nucleotide hydrolysis. A basic biochemical characterization of nsp13 demonstrated that it can unwind both doublestranded DNA and RNA in a 5’-3’ direction, and it can hydrolyze all deoxyribonucleotide and ribonucleotide triphosphates. Helicases are motor proteins that utilize the energy derived from nucleotide hydrolysisto unwind double-stranded nucleic acids into two single-stranded nucleic acids. Initially, helicases were only thought to be molecular engines that unwind nucleic acids during replication, recombination, and DNA repair. Recent studies have shown that they are also involved in other biological processes, including displacement of proteins from nucleic acid, movement of Holliday junctions, chromatin remodeling, catalysis of nucleic acid conformational changes, several aspects of RNA metabolism, including transcription, mRNA splicing, mRNA export, translation, RNA stability and mitochondrial gene expression. Some human diseases, including Bloom’s syndrome, Werner’s syndrome, and Xeroderma Pigmentosum have been associated with defects in helicase function.

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      MSDS for ELISA ISO 9001

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