Recombinant Cynomolgus B7-1/CD80 Protein (Fc Tag)

    • Recombinant Cynomolgus B7-1 / CD80 Protein (C-Fc)-Elabscience
    • Recombinant Protein-Elabscience
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    • Recombinant Cynomolgus B7-1 / CD80 Protein (C-Fc)-Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Cynomolgus B7-1 / CD80 Protein (C-Fc)-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSQ050018

      Synonyms:T-lymphocyte activation antigen CD80; Activation B7-1 antigen; B7; CD80

      Size:
      • 10μg
      • 50μg
      Qty:
      - +
      Price: $70

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      Overview

      Synonyms T-lymphocyte activation antigen CD80; Activation B7-1 antigen; B7; CD80
      Species Cynomolgus
      Expression_host Human Cells
      Sequence Val35-Asn242
      Accession G7NXN7
      Mol_Mass 51 kDa
      AP_Mol_Mass 70-90 kDa
      Tag C-Fc

      Properties

      Purity > 95% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from a 0.2 μm filtered solution of 50 mM Tris, 100 mM Glycine, pH 7.5.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Cynomologous Cluster of Differentiation 80, also called B7-1, is a member of cell surface immunoglobulin superfamily.It is expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells.CD80 plays key, yet distinct roles in the activation of T cells. B7-1/CD80 and B7-2/CD86, together with their receptors CD28 and CTLA4, constitute one of the dominant co-stimulatory pathways that regulate T- and B- cell responses. CD80 is mostly expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20-100 fold higher affinity than CD28 and is involved in the down-regulation of the immune response. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas.

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      MSDS for ELISA ISO 9001

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