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Recombinant Cynomolgus LAG-3/CD223 Protein (His Tag)

Cat:PKSQ050011
Manual MSDS

Price: $ 378

Price: $ 214

Size:
50μg 10μg
Quantity:
  • Expression Host: HEK293 Cells
  • Accession: XP_005570011.1
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Product Details
Synonyms Lymphocyte Activating 3;LAG3;LAG-3;CD223
Species Cynomolgus macaques
Expression Host HEK293 Cells
Sequence Pro23-Leu450(Pro74)
Accession XP_005570011.1
Calculated Molecular Weight 47.3 kDa
Observed Molecular Weight 55-65&140 kDa
Tag N-His
Purity > 90 % as determined by reducing SDS-PAGE.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution Please refer to the printed manual for detailed information.
Background Lymphocyte Activating 3(LAG3) belongs to immunoglobulin (Ig) superfamily, Macaca fascicularis LAG3 cDNA encodes 533 amino acids (aa) that include a 17 aa signal sequence, a 451 aa extracellular domain (ECD) with two Ig-like domains, a transmembrane region and a highly charged cytoplasmic region. LAG3&#39;s main ligand is MHC class II, to which it binds with higher affinity than CD4. The protein negatively regulates cellular proliferation, activation, and homeostasis of T cells, in a similar fashion to CTLA-4 and PD-1 and has been reported to play a role in Treg suppressive function.