Recombinant Cynomolgus LAG-3/CD223 Protein (His Tag)

    • Recombinant Cynomolgus LAG-3 / CD223 Protein (N-His)-Elabscience
    • Recombinant Protein-Elabscience
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    • Recombinant Cynomolgus LAG-3 / CD223 Protein (N-His)-Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Cynomolgus LAG-3 / CD223 Protein (N-His)-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSQ050011

      Synonyms:Lymphocyte Activating 3; LAG3; LAG-3; CD223

      Size:
      • 10μg
      • 50μg
      Qty:
      - +
      Price: $214

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      Overview

      Synonyms Lymphocyte Activating 3; LAG3; LAG-3; CD223
      Species Cynomolgus
      Expression_host Human Cells
      Sequence Pro23-Leu450(Pro74)
      Accession XP_005570011.1
      Application Functional ELISA
      Mol_Mass 47.3 kDa
      AP_Mol_Mass 55-65&140 kDa
      Tag N-His
      Bio_Activity Immobilized Cynomolgus LAG-3-His at 2μg/ml(100 μl/well) can bind Human FGL1-Fc. The ED50 of Cynomolgus LAG-3-His is 5.8 ug/ml .

      Properties

      Purity > 95% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from a 0.2 μm filtered solution of PBS,PH7.4.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Lymphocyte Activating 3(LAG3) belongs to immunoglobulin (Ig) superfamily, Macaca fascicularis LAG3 cDNA encodes 533 amino acids (aa) that include a 17 aa signal sequence, a 451 aa extracellular domain (ECD) with two Ig-like domains, a transmembrane region and a highly charged cytoplasmic region. LAG3's main ligand is MHC class II, to which it binds with higher affinity than CD4. The protein negatively regulates cellular proliferation, activation, and homeostasis of T cells, in a similar fashion to CTLA-4 and PD-1 and has been reported to play a role in Treg suppressive function.

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      MSDS for ELISA ISO 9001

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