Recombinant Human ALK-2 / ACVR1 / ALK2 Protein (His tag)

    • Recombinant Human ALK-2 / ACVR1 / ALK2 Protein (His tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
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    • Recombinant Human ALK-2 / ACVR1 / ALK2 Protein (His tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
    • Recombinant Human ALK-2 / ACVR1 / ALK2 Protein (His tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience

      Catalog number:PKSH030419

      Synonyms:ACTRI;ACVR1A;ACVRLK2;ALK2;FOP;SKR1;TSRI

      Size:
      • 100 µg
      • 200 µg
      Qty:
      - +
      Price: $486

      Lead Time: 7~10 daysWelcome to order from local distributors.

      Add to cart Compare Bulk request Manual

      Overview

      Synonyms ACTRI;ACVR1A;ACVRLK2;ALK2;FOP;SKR1;TSRI
      Species Human
      Expression_host Baculovirus-Insect Cells
      Sequence Met 1-Val 124
      Accession Q04771
      Mol_Mass 12.8 kDa
      AP_Mol_Mass 17 kDa
      Tag C-His

      Properties

      Purity > 93 % as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per µg as determined by the LAL method.
      Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
      Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice.Upon receipt, store it immediately at<-20°C.
      Formulation Supplied as sterile 20mM Tris, 500mM NaCl, pH 7.4, 10% gly
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      ALK-2, also termed as ACVR1, was initially identified as an activin type I receptor because of its ability to bind activin in concert with ActRII or ActRIIB. ALK-2 is also identified as a BMP type I receptor. It has been demonstrated that ALK-2 forms complex with either the BMP-2/7-bound BMPR-II or ACVR2A /ACVR2B. ALK-1 and ALK-2 presenting in the yeast Saccharomyces cerevisiae are two haspin homologues. Both ALK-1 and ALK-2 exhibit a weak auto-kinase activity in vitro, and are phosphoproteins in vivo. ALK-1 and ALK-2 levels peak in mitosis and late-S/G2. Control of protein stability plays a major role in ALK-2 regulation. The half-life of ALK-2 is particularly short in G1. Overexpression of ALK-2, but not of ALK-1, causes a mitotic arrest, which is correlated to the kinase activity of the protein. This suggests a role for ALK-2 in the control of mitosis. Endoglin is phosphorylated on cytosolic domain threonine residues by the TGF-beta type I receptors ALK-2 and ALK-5 in prostate cancer cells. Endoglin did not inhibit cell migration in the presence of constitutively active ALK-2. Defects in ALK-2 are a cause of fibrodysplasia ossificans progressiva (FOP).

      SDS-PAGE

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