Recombinant Human BIM/BCL2L11 Protein (His Tag)

    • Recombinant Human Bcl-2-like Protein 11 / BIML Protein (N-His)-Elabscience
    • Recombinant Protein-Elabscience
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    • Recombinant Human Bcl-2-like Protein 11 / BIML Protein (N-His)-Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Human Bcl-2-like Protein 11 / BIML Protein (N-His)-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSH033749

      Synonyms:Bcl-2-like protein 11; Bcl2-L-11; Bcl2-interacting mediator of cell death; BCL2L11; BIM; BIML

      Size:
      • 10μg
      • 50μg
      Qty:
      - +
      Price: $328

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      Overview

      Synonyms Bcl-2-like protein 11; Bcl2-L-11; Bcl2-interacting mediator of cell death; BCL2L11; BIM; BIML
      Species Human
      Expression_host E.coli
      Sequence Met1-Arg120
      Accession O43521-2
      Mol_Mass 15 kDa
      AP_Mol_Mass 15-18 kDa
      Tag N-His

      Properties

      Purity > 95% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
      Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice.Upon receipt, store it immediately at<-20°C.
      Formulation Supplied as a 0.2 μm filtered solution of 20mM HEPES, 150mM NaCl, 10% glycerol, 2mM DTT, pH8.0.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      BIML is one of several splice variants of BIM, a proapoptotic protein belonging to the BH-3 domain-only subgroup of Bcl-2 family members. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BIML is thought to promote apoptosis by binding and inhibiting the activity of anti-apoptotic Bcl-2 family members, thereby inducing the release of cytochrome c from mitochondria. BIML is normally sequestered in an inactive conformation from anti-apoptotic Bcl-2 family members through binding to the microtubule-associated dynein motor complex. Certain apoptotic stimuli release BIML from microtubules to neutralize anti-apoptotic Bcl-2 family members, allowing for the initiation of apoptosis.

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      MSDS for ELISA ISO 9001

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