Recombinant Human BLK Protein (GST Tag)

    • Recombinant Human BLK Protein (GST Tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
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    • Recombinant Human BLK Protein (GST Tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
    • Recombinant Human BLK Protein (GST Tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience

      Catalog number:PKSH030381

      Synonyms:MODY11

      Size:
      • 20 µg
      • 50 µg
      Qty:
      - +
      Price: $486

      Lead Time: 7~10 daysWelcome to order from local distributors.

      Add to cart Compare Bulk request Manual

      Overview

      Synonyms MODY11
      Species Human
      Expression_host Baculovirus-Insect Cells
      Sequence Met 1-Pro 505
      Accession NP_001706.2
      AP_Mol_Mass 84 kDa
      Tag N-GST
      Bio_Activity The specific activity was determined to be 17.4 nmol/min/mg using Poly(Glu,Tyr)4:1 peptide as substrate.

      Properties

      Purity 90 % as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per µg of the protein as determined by the LAL method.
      Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
      Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice.Upon receipt, store it immediately at<-20°C.
      Formulation Supplied as sterile 20mM Tris, 300mM NaCl, 0.5mM GSH, pH 7.5, 25% glycerol.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Tyrosine-protein kinase Blk, also known as B lymphocyte kinase, p55-Blk and BLK, is a member of the protein kinase superfamily, Tyr protein kinase family and SRC subfamily. BLK / p55-Blk is expressed in lymphatic organs, pancreatic islets, Leydig cells, striate ducts of salivary glands and hair follicles. BLK / p55-Blk is a src-family protein tyrosine kinase specifically expressed in B-lineage cells of mice. The early onset of Blk expression during B-cell development in the bone marrow and the high expression levels of Blk in mature B cells suggest a possible important role of Blk in B-cell physiology. It is a modulator of beta-cells function, acting through the up-regulation of PDX1 and NKX6-1 and consequent stimulation of insulin secretion in response to glucose. Defects in BLK are a cause of maturity-onset diabetes of the young type 11 which is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.

      SDS-PAGE

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