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Recombinant Human Cardiotrophin-1/CTF1 Protein (His Tag)

Uniprot : Q16619

Cat.No.:PKSH032175
Expression host: E.coli

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Description

Synonyms	Cardiotrophin-1;CT-1;CTF1;
Species	Human
Expression_host	E.coli
Sequence	Met 1-Ala201
Accession	Q16619
Mol_Mass	22.6 kDa
AP_Mol_Mass	25 kDa
Tag	N-His

Properties

Purity	> 95 % as determined by reducing SDS-PAGE.
Endotoxin level	< 1.0 EU per μg of the protein as determined by the LAL method.
Storage	Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping	This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Formulation	Supplied as a 0.2 μm filtered solution of PBS, 2mM EDTA, 5% Trehalose, pH 7.4.
Reconstitution	Not Applicable

Background

Cardiotrophin-1, also known as CT-1 and CTF1, is a member of the IL-6 superfamily. It is a sreted cytokine that is expressed in heart, skeletal muscle, prostate and ovary, and to lower levels in lung, kidney, pancreas, thymus, testis and small intestine. The protein exerts its cellular effects by interacting with the glycoprotein 130 (gp130)/leukemia inhibitory factor receptor beta (LIFR) heterodimer. In addition, CT-1 activates phosphatidylinositol 3-kinase (PI-3 kinase) in cardiac myocytes and enhances transcription factor NF-κB DNA -binding activities.

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