Recombinant Human Casein Kinase 1 gamma 2 Protein (His Tag)

    • Recombinant Human Casein Kinase 1 gamma 2 Protein (His Tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
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    • Recombinant Human Casein Kinase 1 gamma 2 Protein (His Tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
    • Recombinant Human Casein Kinase 1 gamma 2 Protein (His Tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience

      Catalog number:PKSH030337

      Synonyms:CK1g2

      Size:
      • 20 µg
      • 50 µg
      Qty:
      - +
      Price: $486

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms CK1g2
      Species Human
      Expression_host Baculovirus-Insect Cells
      Sequence Met 18-Lys 415
      Accession P78368-1
      Mol_Mass 47.8 kDa
      AP_Mol_Mass 48 kDa
      Tag N-His
      Bio_Activity The specific activity was determined to be 13 nmol/min/mg using casein as substrate.

      Properties

      Purity > 80 % as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per µg of the protein as determined by the LAL method.
      Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
      Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice.Upon receipt, store it immediately at<-20°C.
      Formulation Supplied as sterile 20mM Tris, 500mM NaCl, 10% gly, 1mM DTT, pH 8.0
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Casein kinase I gamma 2 isoform (CSNK1G2), a member of the large casein kinase I (CKI) subfamily, protein kinase superfamily. It may affect the development of brain, and associate with vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. The CKI family includes several other isoforms (alpha, beta, gamma, and delta). Dishevelled (Dsh), another positive component of the Wnt pathway, becomes phosphorylated in response to Wnt signals. All the CKI isoforms, with the exception of gamma, increase the phosphorylation of Dsh in vivo. Casein kinase 1 gamma (CK1gamma, or CSNK1G) is associated with the cell membrane and binds to LRP. CK1gamma was found to be needed for Wnt signaling through Wnt receptor LRP. CSNK1G2 inhibits Smad3-mediated TGF-beta responses including induction of target genes and cell growth arrest, and this inhibition is dependent on CSNK1G2 kinase activity. The overexpression of CSNK1G2 in human cancers, may act as an oncoprotein during tumorigenesis. In addition, as an MTA1s-binding protein, CSNK1G2 could further potentiate the estrogen receptor (ER) corepressive function of MTA1s.

      SDS-PAGE

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      MSDS for ELISA

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