Recombinant Human CD16a / FCGR3A Protein (176 Phe, His tag)

    • Recombinant Human CD16a / FCGR3A Protein (176 Phe, His tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
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    • Recombinant Human CD16a / FCGR3A Protein (176 Phe, His tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
    • Recombinant Human CD16a / FCGR3A Protein (176 Phe, His tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience

      Catalog number:PKSH030287

      Synonyms:CD16;CD16A;Fc gamma RIIIa;FCG3;FCGR3;FCGRIII;FCR-10;FCRIII;FCRIIIA;IGFR3;IMD20

      Size:
      • 50 µg
      • 100 µg
      Qty:
      - +
      Price: $454

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms CD16;CD16A;Fc gamma RIIIa;FCG3;FCGR3;FCGRIII;FCR-10;FCRIII;FCRIIIA;IGFR3;IMD20
      Species Human
      Expression_host HEK293 Cells
      Sequence Met 1-Gln 208
      Accession P08637-1
      Mol_Mass 23.3 kDa
      AP_Mol_Mass 45-50 kDa
      Tag C-His
      Bio_Activity Measured by its binding ability in a functional ELISA. Immobilized human CD16a-His at 10 μg/ml (100 μl/well) can bind biotinylated human IgG1, The EC50 of biotinylated human IgG1 is 0.90-2.30 μg/ml.

      Properties

      Purity > 97 % as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per µg as determined by the LAL method.
      Storage Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from sterile PBS, pH 7.4
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      The Fc receptor with low affinity for IgG (FCGR3, or CD16) is encoded by 2 nearly identical genes, FCGR3A and FCGR3B, resulting in tissue-specific expression of alternative membrane-anchored isoforms. FCGR3A, it is also known as CD16a, encodes a transmembrane protein expressed on activated monocytes/macrophages, natural killer (NK) cells, and a subset of T cells. CD16a / FCGR3A is a receptor expressed on NK cells that facilitates antibody dependent cellular cytotoxicity (ADCC) by binding to the Fc portion of various antibodies. CD16a / FCGR3A also has a broader function. CD16a / FCGR3A is directly involved in the lysis of some virus-infected cells and tumor cells by NK cells, independent of antibody binding. Cross-linking of CD16a / FCGR3A on NK cells resulted in increased intracellular Ca2+ levels and a cascade of biochemical events similar to those activated by the T cell receptor. CD16a / FCGR3A on human NK cells is a lysis receptor that mediates the direct killing of some virus infected and tumor cells, independent of antibody ligation.

      SDS-PAGE

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