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Recombinant Human CD30/TNFRSF8 Protein (His & Fc Tag)(Active)

  • Cat.No.:PKSH031432

  • Expression host: HEK293 Cells

To Purchase PKSH031432

Size:
  • 100μg
  • 200μg
Price: $486
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Description

Synonyms Tumor necrosis factor receptor superfamily member 8; CD30L receptor; Ki-1 antigen; Lymphocyte activation antigen CD30; CD30; TNFRSF8;D1S166E
Species Human
Expression_host HEK293 Cells
Sequence Met 1-Lys 379
Accession NP_001234.2
Application Functional ELISA
Mol_Mass 66.5 kDa
AP_Mol_Mass 130 kDa
Tag C-His & Fc
Bio_Activity Measured by its binding ability in a functional ELISA. Immobilized recombinant human CD30L at 20 μg/ml (100 μl/well) can bind biotinylated human CD30 with a linear range of 0.31-20 ng/ml.

Properties

Purity > 90 % as determined by reducing SDS-PAGE.
Endotoxin level < 1.0 EU per µg as determined by the LAL method.
Storage Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from sterile PBS, pH 7.4
Reconstitution Please refer to the printed manual for detailed information.

Background

CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor (TNFR) superfamily. CD30 protein is expressed by activated, but not resting, T and B cells. CD30 can regulate proliferation of lymphocytes and may also play an important role in human immunodeficiency virus replication. As a regulator of apoptosis, CD30 protein induces cell death or proliferation, depending on the cell type, and has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. CD30 protein expression is upregulated in various hematological malignancies, including Reed-Sternberg cells in Hodgkin's disease (HD), anaplastic large cell lymphoma (ALCL) and subsets of Non-Hodgkin's lymphomas (NHLs), and CD30 is also linked to leukocytes in patients with chronic inflammatory diseases, including lupus erythematosus, asthma, rheumatoid arthritis and atopic dermatitis (AD).

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