Recombinant Human CD6 / Cluster of Differentiation 6 Protein (Fc Tag)

    • Recombinant Human CD6 / Cluster of Differentiation 6 Protein (Fc Tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
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    • Recombinant Human CD6 / Cluster of Differentiation 6 Protein (Fc Tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
    • Recombinant Human CD6 / Cluster of Differentiation 6 Protein (Fc Tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience

      Catalog number:PKSH030430

      Synonyms:TP120

      Size:
      • 20 µg
      • 100 µg
      Qty:
      - +
      Price: $206

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms TP120
      Species Human
      Expression_host HEK293 Cells
      Sequence Met 1-Glu398
      Accession NP_006716.3
      Mol_Mass 67.3 kDa
      Tag C-Fc
      Bio_Activity Measured by the ability of the immobilized protein to support the adhesion of Jurkat human acute T cell leukemia cells.When 8×10E4 cells/well are added to CD6-Fc coated plates (10 μg/mL, 100 μL/well), approximately >70% will adhere after 60 minutes at 37℃.

      Properties

      Purity > 95 % as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per µg as determined by the LAL method.
      Storage Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from sterile PBS, pH 7.4
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      T-cell differentiation antigen CD6, also known as TP120 and CD6, is a single-pass type I membrane protein which contains three SRCR domains. CD6 / TP120 is a cell surface glycoprotein expressed primarily on T cells, it may function as a costimulatory molecule and may play a role in autoreactive immune responses. CD6 / TP120 is expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some cells in the brain. CD6 ligand termed CD166 (previously known as activated leukocyte cell adhesion molecule, ALCAM ) has been identified and shown to be expressed on activated T cells, B cells, thymic epithelium, keratinocytes, and in rheumatoid arthritis synovial tissue. CD6 / TP120 binds to activated leukocyte cell adhesion molecule ( CD166 ), and is considered as a costimulatory molecule involved in lymphocyte activation and thymocyte development. CD6 / TP120 partially associates with the TCR / CD3 complex and colocalizes with it at the center of the mature immunological synapse (IS) on T lymphocytes. During thymic development CD6-dependent signals may contribute both to thymocyte survival, and to the overall functional avidity of selection in both man and mouse.

      SDS-PAGE

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