Recombinant Human CD86/B7-2 Protein (Val185Ile, His Tag)(Active)

    • Recombinant Human B7-2 / CD86 Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience
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    • Recombinant Human B7-2 / CD86 Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Human B7-2 / CD86 Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSH033722

      Synonyms:T-Lymphocyte Activation Antigen CD86; Activation B7-2 Antigen; B70; BU63; CTLA-4 Counter-Receptor B7.2; FUN-1; CD86; CD28LG2;B7-2;B7.2;CD28LG2;LAB72

      Size:
      • 10μg
      • 50μg
      Qty:
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      Price: $62

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      Overview

      Synonyms T-Lymphocyte Activation Antigen CD86; Activation B7-2 Antigen; B70; BU63; CTLA-4 Counter-Receptor B7.2; FUN-1; CD86; CD28LG2;B7-2;B7.2;CD28LG2;LAB72
      Species Human
      Expression_host Human Cells
      Sequence Ala24-Pro247(Val185Ile)
      Accession P42081
      Application Functional ELISA
      Mol_Mass 26.69 kDa
      AP_Mol_Mass 50 kDa
      Tag C-His
      Bio_Activity Immobilized Human CTLA-4-Fc-Avi(Cat: PKSH033803) at 2μg/ml(100 μl/well) can bind Human B7-2-His. The ED50 of Human B7-2-His is 1.98ug/ml .

      Properties

      Purity > 95% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      The protein is the receptor that involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. It may play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation. The protein interacts with MARCH8, human herpesvirus 8 MIR2 protein, adenovirus subgroup B fiber proteins and acts as a receptor for these viruses.It is expressed by activated B-lymphocytes and monocytes and promoted by MARCH8 and results in endocytosis and lysosomal degradation.It contains 1 Ig-like C2-type(immunoglobulin-like) domainand 1 Ig-like V-type (immunoglobulin-like) domain.

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      MSDS for ELISA ISO 9001

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