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Recombinant Human CHI3L2/YKL-39 Protein (His Tag)

  • Cat.No.:PKSH033718

  • Expression host: Human Cells

To Purchase PKSH033718

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  • 50μg
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Description

Synonyms Chitinase-3-Like Protein 2; Chondrocyte Protein 39; YKL-39; CHI3L2;CHIL2;YKL-39;YKL39
Species Human
Expression_host Human Cells
Sequence Tyr27-Leu390
Accession AAH11460.1
Mol_Mass 41.94 kDa
AP_Mol_Mass 40 kDa
Tag C-His

Properties

Purity > 95% as determined by reducing SDS-PAGE.
Endotoxin level < 1.0 EU per μg as determined by the LAL method.
Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Reconstitution Please refer to the printed manual for detailed information.

Background

Chitinase 3-Like Protein 2 (CHI3L2) is a 39 kDa secreted glycoprotein which belongs to the glycosyl hydrolase 18 family and the most closely related to human cartilage glycoprotein 39, which promotes the growth of human synovial cells as well as skin and fetal lung fibroblasts. Highest expression of CHI3L2 is in chondrocytes, followed by synoviocytes, lung and heart. It is not detected in spleen, pancreas, and liver. CHI3L2 may also be expressed in developing brain and placenta. Increased levels of CHI3L2 have been demonstrated in synovial fluids of patients with rheumatoid or osteoarthritis as well as in some other pathologies and in malignant tumors, particularly in glioblastomas. CHI3L2 may bind glycan structure with high affinity, but not heparin. It has has no chitotriosidase activity, but is likely to bind some type of glycan.

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