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Recombinant Human CHI3L2/YKL-39 Protein (His Tag)

Cat:PKSH033718
Manual MSDS

Price: $ 375

Price: $ 129

Size:
50μg 10μg
Quantity:
  • Expression Host: HEK293 Cells
  • Accession: AAH11460.1
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Product Details
Synonyms Chitinase-3-Like Protein 2;Chondrocyte Protein 39;YKL-39;CHI3L2;CHIL2;YKL-39;YKL39
Species Human
Expression Host HEK293 Cells
Sequence Tyr27-Leu390
Accession AAH11460.1
Calculated Molecular Weight 41.9 kDa
Observed Molecular Weight 40 kDa
Tag C-His
Purity > 95 % as determined by reducing SDS-PAGE.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS, 5% Trehalose, 5% Mannitol, 0.01% Tween 80, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution Please refer to the printed manual for detailed information.
Background Chitinase 3-Like Protein 2 (CHI3L2) is a 39 kDa secreted glycoprotein which belongs to the glycosyl hydrolase 18 family and the most closely related to human cartilage glycoprotein 39, which promotes the growth of human synovial cells as well as skin and fetal lung fibroblasts. Highest expression of CHI3L2 is in chondrocytes, followed by synoviocytes, lung and heart. It is not detected in spleen, pancreas, and liver. CHI3L2 may also be expressed in developing brain and placenta. Increased levels of CHI3L2 have been demonstrated in synovial fluids of patients with rheumatoid or osteoarthritis as well as in some other pathologies and in malignant tumors, particularly in glioblastomas. CHI3L2 may bind glycan structure with high affinity, but not heparin. It has has no chitotriosidase activity, but is likely to bind some type of glycan.