Recombinant Human DAPK3 / ZIPK Protein (GST tag)

    • Recombinant Human DAPK3 / ZIPK Protein (GST tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
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    • Recombinant Human DAPK3 / ZIPK Protein (GST tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
    • Recombinant Human DAPK3 / ZIPK Protein (GST tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience

      Catalog number:PKSH030384

      Synonyms:DLK;ZIP;ZIPK

      Size:
      • 20µg
      • 50µg
      Qty:
      - +
      Price: $486

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms DLK;ZIP;ZIPK
      Species Human
      Expression_host Baculovirus-Insect Cells
      Sequence Met 1-Arg 454
      Accession NP_001339.1
      Mol_Mass 79 kDa
      AP_Mol_Mass 70 kDa
      Tag N-GST
      Bio_Activity The specific activity was determined to be 5 nmol/min/mg using MBP as substrate.

      Properties

      Purity > 85 % as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per µg as determined by the LAL method.
      Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
      Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt, store it immediately at<-20°C.
      Formulation Supplied as sterile 20mM Tris, 500mM NaCl, 10mM GSH, pH 7.4
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Death-associated protein kinase 3, also known as DAP kinase 3, ZIP-kinase, DAPK3 and ZIPK, is a nucleus and cytoplasm protein which belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family and DAP kinase subfamily. DAPK3 / ZIPK contains one protein kinase domain. It is a serine/threonine kinase which acts as a positive regulator of apoptosis. It phosphorylates histone H3 on 'Thr-11' at centromeres during mitosis. DAPK3 / ZIPK is a homodimer or forms heterodimers with ATF4. Both interactions require an intact leucine zipper domain and oligomerization is required for full enzymatic activity. It also binds to DAXX and PAWR, possibly in a ternary complex which plays a role in caspase activation. DAPK3 / ZIPK regulates myosin light chain phosphatase through phosphorylation of MYPT1 thereby regulating the assembly of the actin cytoskeleton, cell migration, invasiveness of tumor cells, smooth muscle contraction and neurite outgrowth. It is involved in the formation of promyelocytic leukemia protein nuclear body (PML-NB), one of many subnuclear domains in the eukaryotic cell nucleus, and which is involved in oncogenesis and viral infection.

      SDS-PAGE

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