Recombinant Human DDR1 Kinase / MCK10 / CD167 Protein (aa 444-913, His & GST tag)

    • Recombinant Human DDR1 Kinase / MCK10 / CD167 Protein (aa 444-913, His & GST tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
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    • Recombinant Human DDR1 Kinase / MCK10 / CD167 Protein (aa 444-913, His & GST tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
    • Recombinant Human DDR1 Kinase / MCK10 / CD167 Protein (aa 444-913, His & GST tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience

      Catalog number:PKSH030389

      Synonyms:CAK;CD167;DDR;EDDR1;HGK2;MCK10;NEP;NTRK4;PTK3;PTK3A;RTK6;TRKE

      Size:
      • 20µg
      • 50µg
      Qty:
      - +
      Price: $486

      Lead Time: 7~10 daysWelcome to order from local distributors.

      Add to cart Compare Bulk request Manual

      Overview

      Synonyms CAK;CD167;DDR;EDDR1;HGK2;MCK10;NEP;NTRK4;PTK3;PTK3A;RTK6;TRKE
      Species Human
      Expression_host Baculovirus-Insect Cells
      Sequence Arg444-Val913
      Accession Q08345-1
      Mol_Mass 80 kDa
      AP_Mol_Mass 80 kDa
      Tag N-His & GST
      Bio_Activity The specific activity was determined to be 2.75 nmol/min/mg using synthetic AXLtide peptide(CKKSRGDYMTMQIG) as substrate.

      Properties

      Purity > 89 % as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per µg as determined by the LAL method.
      Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
      Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt, store it immediately at<-20°C.
      Formulation Supplied as sterile 20mM Tris, 500mM NaCl, pH 7.4, 10% glycerol, 3mM DTT
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Discoidin domain receptor family, member 1 (DDR1), also known as or CD167a (cluster of differentiation 167a), and Mammary carcinoma kinase 10 (MCK10), belongs to a subfamily of tyrosine kinase receptors with an extracellular domain homologous to Dictyostellium discoideum protein discoidin 1. Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. Expression of DDR1/MCK10/CD167 is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. DDR1/MCK10/CD167 plays an important role in regulating attachment to collagen, chemotaxis, proliferation, and MMP production in smooth muscle cells. DDR1 functions in a feedforward loop to increase p53 levels and at least some of its effectors. Inhibition of DDR1 function resulted in strikingly increased apoptosis of wild-type p53-containing cells in response to genotoxic stress through a caspase-dependent pathway.

      SDS-PAGE

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