Recombinant Human DDR2 Kinase / CD167b Protein (aa 422-855, His & GST tag)

    • Recombinant Human DDR2 Kinase / CD167b Protein (aa 422-855, His & GST tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
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    • Recombinant Human DDR2 Kinase / CD167b Protein (aa 422-855, His & GST tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
    • Recombinant Human DDR2 Kinase / CD167b Protein (aa 422-855, His & GST tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience

      Catalog number:PKSH030420

      Synonyms:CD167;MIG20a;NTRKR3;TKT;TYRO10

      Size:
      • 20µg
      • 50µg
      Qty:
      - +
      Price: $486

      Lead Time: 7~10 daysWelcome to order from local distributors.

      Add to cart Compare Bulk request Manual

      Overview

      Synonyms CD167;MIG20a;NTRKR3;TKT;TYRO10
      Species Human
      Expression_host Baculovirus-Insect Cells
      Sequence Arg422-Glu855
      Accession Q16832
      Mol_Mass 77.1 kDa
      AP_Mol_Mass 77 kDa
      Tag N-His & GST
      Bio_Activity The specific activity was determined to be 8 nmol/min/mg using synthetic AXLtide peptide(CKKSRGDYMTMQIG) as substrate.

      Properties

      Purity > 95 % as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per µg as determined by the LAL method.
      Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
      Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt, store it immediately at<-20°C.
      Formulation Supplied as sterile 20mM Tris, 500mM NaCl, pH 7.4, 10% glycerol
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Discoidin domain receptor 2 (DDR2) or CD167b (cluster of differentiation 167b) is a kind of protein tyrosine kinases associated with cell proliferation and tumor metastasis, and collagen, identified as a ligand for DDR2, up-regulates matrix metallloproteinase 1 (MMP-1) and MMP-2 expression in cellular matrix. DDR2/CD167b was found to recognise the triple-helical region of collagen X as well as the NC1 domain. Binding to the collagenous region was dependent on the triple-helical conformation. DDR2/CD167b autophosphorylation was induced by the collagen X triple-helical region but not the NC1 domain, indicating that the triple-helical region of collagen X contains a specific DDR2 binding site that is capable of receptor activation. DDR2/CD167b is induced during stellate cell activation and implicate the phosphorylated receptor as a mediator of MMP-2 release and growth stimulation in response to type I collagen. Moreover, type I collagen-dependent upregulation of DDR2/CD167b expression establishes a positive feedback loop in activated stellate cells, leading to further proliferation and enhanced invasive activity.

      SDS-PAGE

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