Recombinant Human Decorin Protein (Baculovirus, His Tag)

    • Recombinant Human Decorin Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience
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    • Recombinant Human Decorin Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Human Decorin Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSH033701

      Synonyms:Decorin; Bone proteoglycan II; PG-S2; PG40; DCN; SLRR1B

      Size:
      • 10μg
      • 50μg
      Qty:
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      Price: $62

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      Overview

      Synonyms Decorin; Bone proteoglycan II; PG-S2; PG40; DCN; SLRR1B
      Species Human
      Expression_host Baculovirus
      Sequence Gly17-Lys359
      Accession P07585
      Mol_Mass 38.8 kDa
      AP_Mol_Mass 40-45 kDa
      Tag C-His

      Properties

      Purity > 95% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Decorin is a secreted chondroitin/dermatan sulfate proteoglycan in the family of small leucine-rich proteoglycans (SLRPs). SLRP family members are characterized by N-terminal and C-terminal cysteine-rich regions which flank the central region containing 10-12 tandem leucine-rich repeats (LRR). The human Decorin cDNA encodes a 359 amino acid (aa) precursor that includes a 16 aa signal sequence and a 14 aa propeptide. Alternate splicing of human Decorin generates five isoforms with variable length deletions. Decorin is an N-glycosylated protein that also carries a variablysized hybrid chondroitin/dermatan sulfate chain at Ser34. Decorin regulates assembly of the extracellular collagen matrix and the bioactivity of the matrix associated growth factors FGF2,GDF8/Myostatin, TGFβ,and WISP1. It also binds and activates EGF R, ErbB4, and IGFI-R. In vivo, Decorin promotes myoblast differentiation, supports angiogenesis, and inhibits tumor progression.

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