Recombinant Human DYRK3 / REDK Protein (His & GST tag)

    • Recombinant Human DYRK3 / REDK Protein (His & GST tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
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    • Recombinant Human DYRK3 / REDK Protein (His & GST tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
    • Recombinant Human DYRK3 / REDK Protein (His & GST tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience

      Catalog number:PKSH030392

      Synonyms:DYRK5;hYAK3-2;RED;REDK

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      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms DYRK5;hYAK3-2;RED;REDK
      Species Human
      Expression_host Baculovirus-Insect Cells
      Sequence Met 1-Ser 588
      Accession O43781-1
      Mol_Mass 93.5 kDa
      AP_Mol_Mass 80 kDa
      Tag N-His & GST
      Bio_Activity The specific activity was determined to be 22 nmol/min/mg using synthetic DYRKtide peptide (RRRFRPASPLRGPPK) as substrate.

      Properties

      Purity > 85 % as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per µg as determined by the LAL method.
      Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt, store it immediately at<-20°C.
      Formulation Supplied as sterile 20mM Tris, 500mM NaCl, 0.5mM PMSF, 10% gly, pH 8.0
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Dual specificity tyrosine-phosphorylation-regulated kinase 3, also known as Regulatory erythroid kinase, REDK and DYRK3, is a nucleus protein which belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family and MNB/DYRK subfamily. DYRKs are an emerging family of dual-specificity kinases that play key roles in cell proliferation, survival, and development. DYRK3 contains one protein kinase domain. Isoform 1 and isoform 2 of DYRK3 are highly expressed in testis and in hematopoietic tissue such as fetal liver, and bone marrow. Isoform 2 of DYRK3 is the predominant form in testis. Isoform 1 of DYRK3 is the predominant form in fetal liver and bone marrow. Isoform 1 and isoform 2 are present at low levels in heart, pancreas, lymph node, and thymus. DYRK3 is a negative regulator of EPO-dependent erythropoiesis. It may place an upper limit on red cell production during stress erythropoiesis. DYRK3 inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells. It may also act by regulating CREB/CRE signaling. DYRK3 proved to effectively inhibit NFAT (nuclear factor of activated T cells) transcriptional response pathways and to co-immunoprecipitate with NFATc3. DYRK3 attenuates (and possibly apportions) red cell production selectively during anemia.

      SDS-PAGE

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