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Recombinant Human ERK3/MAPK12 Protein

Cat:PKSH030317
Manual MSDS

Price: $ 717

Size:
50μg
Quantity:
  • Expression Host: Baculovirus-Insect Cells
  • Accession: P53778
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For research use only. Order now, ship in 3 days

Product Details
Synonyms ERK-6;ERK3;ERK6;MAPK12;P38GAMMA;PRKM12;SAPK-3;SAPK3;P38-gamma
Species Human
Expression Host Baculovirus-Insect Cells
Sequence Met 1-Leu 367
Accession P53778
Calculated Molecular Weight 42.1 kDa
Observed Molecular Weight 43 kDa
Tag None
Purity > 95 % as determined by reducing SDS-PAGE.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Formulation Supplied as sterile solution of 20mM Tris, 500mM NaCl, 10% glycerol, pH 8.0
Reconstitution Not Applicable
Background ERK3; also known as MAPK12 and p38-gamma; belongs to theprotein kinase superfamily; CMGC Ser/Thr protein kinase family and MAP kinase subfamily. ERK3 is highly expressed in skeletal muscle and heart.ERK3 is a serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly; p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK12 is required for the normal kinetochore localization of PLK1; prevents chromosomal instability and supports mitotic cell viability. MAPK12-signaling is also positively regulating the expansion of transient amplifying myogenic precursor cells during muscle growth and regeneration.