Recombinant Human Fibronectin / Fibronectin Fragment 2 Protein (His tag)

    • Recombinant Human Fibronectin / Fibronectin Fragment 2 Protein (His tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
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    • Recombinant Human Fibronectin / Fibronectin Fragment 2 Protein (His tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
    • Recombinant Human Fibronectin / Fibronectin Fragment 2 Protein (His tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience

      Catalog number:PKSH030452

      Synonyms:CIG;ED-B;FINC;FN;FNZ;GFND;GFND2;LETS;MSF

      Size:
      • 100 µg
      • 200 µg
      Qty:
      - +
      Price: $285

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms CIG;ED-B;FINC;FN;FNZ;GFND;GFND2;LETS;MSF
      Species Human
      Expression_host HEK293 Cells
      Sequence Ser 607-Pro 1265
      Accession CAD91166
      Mol_Mass 73.2 kDa
      AP_Mol_Mass 85-100 kDa
      Tag C-His
      Bio_Activity Measured by the ability of the immobilized protein to support the adhesion of NIH-3T3 mouse embryonic fibroblast cells. When 5 × 10E4 cells/well areadded to CD4-coated plates (1.25μg/mL and 100μL/well),approximately 50%-80% will adhere specifically after 30 minutes at 37℃.

      Properties

      Purity > 97 % as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per µg as determined by the LAL method.
      Storage Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from sterile PBS, pH 7.2
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Fibronectin (FN) is a glycoprotein component of the extracellular matrix of the extracellular matrix (ECM) with roles in embryogenesis, development, and wound healing. More recently, FN has emerged as player in platelet thrombus formation and diseases associated with thrombosis including vascular remodeling, atherosclerosis, and cardiac repair following a myocardial infarct. Each monomer of FN consists of three types of homologous repeating units, that is 12 type I repeats, two type II repeats and 15-17 type III repeats. The occurrence of multiple isoforms results from alternative mRNA splicing of the ED-A, ED-B and III-CS regions, and subsequent post-translational modification. As an ECM component and one of the primary cell adhesion molecules, Fibronectin can be a ligand for fibrin, heparin, chondroitin sulfate, collagen/gelatin, as well as many integrin receptors through which FN mediates the variety of cellular signaling pathways. The study of solid human tumors showed among the early signs of malignant transformation the fragmentation of pericellular FN, concommitent with the increase of its production by the peritumoral stroma. These results should encourage further investigations concerning the potential importance of Fn production and breakdown during cancer progression. FN1 expression has been described to increase significantly from the morula towards the early blastocyst stage, suggesting that FN1 may also be involved in early blastocyst formation. The fragment 2 of FN comprises the first 7 FN type III repeats and is suggested to be important for self association during fibril growth via the key module III2.

      SDS-PAGE

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      MSDS for ELISA

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