Recombinant Human IDO1 / IDO Protein (His tag)

    • Recombinant Human IDO1 / IDO Protein (His tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
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    • Recombinant Human IDO1 / IDO Protein (His tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
    • Recombinant Human IDO1 / IDO Protein (His tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience

      Catalog number:PKSH030356

      Synonyms:IDO;IDO-1;INDO;Indoleamine 2,3‑dioxygenase

      Size:
      • 10 µg
      • 20 µg
      Qty:
      - +
      Price: $584

      Lead Time: 7~10 daysWelcome to order from local distributors.

      Add to cart Compare Bulk request Manual

      Overview

      Synonyms IDO;IDO-1;INDO;Indoleamine 2,3‑dioxygenase
      Species Human
      Expression_host E.coli
      Sequence Ala 2-Gly 403
      Accession P14902-1
      Mol_Mass 46 kDa
      AP_Mol_Mass 44 kDa
      Tag N-His
      Bio_Activity Measured by its ability to oxidize L-tryptophan to N-formylk-ynurenine.The specific activity is > 400 pmoles/min/μg.

      Properties

      Purity > 88 % as determined by reducing SDS-PAGE.
      Endotoxin Please contact us for more information.
      Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
      Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice.Upon receipt, store it immediately at<-20°C.
      Formulation Supplied as sterile 50mM Tris, 0.15M NaCl, 10% glycerol, pH 8.0
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Indoleamine 2,3-dioxygenase-1, also known as Indoleamine-pyrrole 2,3-dioxygenase, IDO1 and IDO, is a member of the indoleamine 2,3-dioxygenase family. IDO1 / IDO and tryptophan 2,3-dioxygenase (TDO) are tryptophan-degrading enzymes that catalyze the first step in tryptophan catabolism via the kynurenine pathway. TDO is widely distributed in both eukaryotes and bacteria. In contrast, IDO has been found only in mammals and yeast. In 2007, a third enzyme, indoleamine 2,3-dioxygenase-2 (IDO2), was discovered. IDO2 is found not only in mammals but also in lower vertebrates. IDO1 / IDO is an immunosuppressive molecule inducible in various cells. IDO1 / IDO catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen. It mediates oxidative cleavage of tryptophan, an amino acid essential for cell proliferation and survival. IDO1 / IDO inhibition is proposed to have therapeutic potential in immunodeficiency-associated abnormalities, including cancer. The IDO pathway is activated in multiple tumor types. Selective inhibition of IDO1 may represent an attractive cancer therapeutic strategy via up-regulation of cellular immunity. IDO1 / IDO is an enzyme that suppresses adaptive T-cell immunity by catabolizing tryptophan from the cellular microenvironment. Inhibition of IDO pathway might enhance the efficacy of immunotherapeutic strategies for cancer.

      SDS-PAGE

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      MSDS for ELISA

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