Recombinant Human IL18 / Interleukin 18 / IGIF Protein (GST tag)

    • Recombinant Human IL18 / Interleukin 18 / IGIF Protein (GST tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
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    • Recombinant Human IL18 / Interleukin 18 / IGIF Protein (GST tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
    • Recombinant Human IL18 / Interleukin 18 / IGIF Protein (GST tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience

      Catalog number:PKSH030306

      Synonyms:IGIF;IL-18;IL-1g;IL1F4;Interleukin 18

      Size:
      • 20 μg
      • 50 μg
      Qty:
      - +
      Price: $322

      Lead Time: 7~10 daysWelcome to order from local distributors.

      Add to cart Compare Bulk request Manual

      Overview

      Synonyms IGIF;IL-18;IL-1g;IL1F4;Interleukin 18
      Species Human
      Expression_host E.coli
      Sequence Met 1-Asp 193
      Accession Q14116
      Mol_Mass 48.6 kDa
      Tag N-GST

      Properties

      Purity > 85 % as determined by reducing SDS-PAGE.
      Endotoxin Please contact us for more information.
      Storage Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from sterile PBS, pH 7.5
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Interleukin-18 (IL-18, also known as interferon-gamma inducing factor) is a proinflammatory cytokine that belongs to the IL-1 superfamily and is produced by macrophages and other cells. This cytokine can induce the IFN-gamma production of T cells. The combination of IL-18 and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. IL-18 is an IL-1−like cytokine that requires cleavage with caspase-1 to become active, was found to increase IgE production in a CD4+ T cells-, IL-4− and STAT6−dependent fashion. IL-18 and T cell receptor−mediated stimulation could induce naïve CD4+ T cells to develop into IL-4−producing cells in vitro. Thus, caspase-1 and IL-18 may be critical in regulation of IgE production in vivo, providing a potential therapeutic target for allergic disorders. IL-18 production in primary synovial cultures and purified synovial fibroblasts was, in turn, upregulated by TNF-α and IL-1β, suggesting that monokine expression can feed back to promote Th1 cell development in synovial membrane. Besides, synergistic combinations of IL-18, IL-12, and IL-15 may be of importance in sustaining both Th1 responses and monokine production in RA.

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