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Recombinant Human IL3RA/CD123 Protein (Fc & Avi Tag)

Uniprot : P26951

Cat.No.:PKSH033800
Expression host: HEK293 Cells

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Description

Synonyms	Interleukin-3 receptor subunit alpha;IL-3 receptor subunit alpha;IL-3R subunitalpha;IL-3R-alpha;IL-3RA
Species	Human
Expression_host	HEK293 Cells
Sequence	Thr19-Arg305
Accession	P26951
Mol_Mass	61.8 kDa
AP_Mol_Mass	80-100 kDa
Tag	C-Fc-Avi

Properties

Purity	> 90 % as determined by reducing SDS-PAGE.
Endotoxin level	< 1.0 EU per μg of the protein as determined by the LAL method.
Storage	Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Formulation	Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual.
Reconstitution	Please refer to the printed manual for detailed information.

Background

CD123; also known as Interleukin-3 receptor subunit alpha; belongs to the type I cytokine receptor family. In mouse; there are two classes of high-affinity IL3 receptors. One contains an IL3-specific beta subunit and the other contains the beta subunit also shared by high-affinity IL5 and GM-CSF receptors. CD123 stimulates the proliferation and differentiation of hemopoietic cells including the pluripotent hematopoietic stem cells as well as various lineage?committed cells. CD123 is a heterodimer consisting of an alpha and a beta subunit. The alpha subunit alone binds IL?3 with low affinity. The beta subunit does not bind IL?3 by itself but is required for the high?affinity binding of IL?3 to the heterodimeric receptor complex.

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