Recombinant Human IL-15 / IL15 / Interleukin 15 Protein

    • Recombinant Human IL-15 / IL15 / Interleukin 15 Protein-Elabscience
    • Recombinant protein products for various applications-Elabscience
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    • Recombinant Human IL-15 / IL15 / Interleukin 15 Protein-Elabscience
    • Recombinant protein products for various applications-Elabscience
    • Recombinant Human IL-15 / IL15 / Interleukin 15 Protein-Elabscience
    • Recombinant protein products for various applications-Elabscience

      Catalog number:PKSH030302

      Synonyms:IL-15;Interleukin 15

      Size:
      • 10 µg
      • 50 µg
      Qty:
      - +
      Price: $281

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms IL-15;Interleukin 15
      Species Human
      Expression_host E.coli
      Sequence Asn 49-Ser 162
      Accession NP_000576.1
      Mol_Mass 12.8 kDa
      Bio_Activity Measured in a cell proliferation assay using MO7e human megakaryocytic leukemic cells.The EC50 for this effect is typically 0.8-4 ng/mL.

      Properties

      Purity > 95 % as determined by reducing SDS-PAGE.
      Endotoxin < 0.1 EU per µg cytokine as determined by the LAL method.
      Storage Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from sterile 50 mM Tris, 200 mM NaCl, pH 8.0
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      The protein encoded by IL15 gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported.

      SDS-PAGE

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