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Recombinant Human IL-1RAcP/IL1R3 Protein (Fc & His Tag)

Uniprot : Q9NPH3

Cat.No.:PKSH032559
Expression host: HEK293 Cells

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Description

Synonyms	Interleukin-1 Receptor Accessory Protein;IL-1 Receptor Accessory Protein;IL-1RAcP;Interleukin-1 Receptor 3;IL-1R-3;IL-1R3;IL1RAP;C3orf13;IL1R3
Species	Human
Expression_host	HEK293 Cells
Sequence	Ser21-Gln356
Accession	Q9NPH3-2
Mol_Mass	66.7 kDa
AP_Mol_Mass	80-100 kDa
Tag	C-Fc-His

Properties

Purity	> 95 % as determined by reducing SDS-PAGE.
Endotoxin level	< 1.0 EU per μg of the protein as determined by the LAL method.
Storage	Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Formulation	Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual.
Reconstitution	Please refer to the printed manual for detailed information.

Background

Interleukin-1 Receptor Accessory Protein (IL-1RAcP) is a member of the interleukin-1 receptor family. It contains three Ig-like C2-type domains in the extracellular region and a long cytoplasmic domain implicated in signal transduction. IL-1RAcP acts as a non-ligand binding accessory component of the receptors for IL1α; IL1βand IL33. IL-1RAcP mediates interleukin-1-dependent activation of NF-kappa-B. It is part of the membrane-bound form of the IL-1 receptor. IL-1 RAcP takes part in the Signaling ways by the formation of a ternary complex containing IL1R1; TOLLIP; MYD88; and IRAK1 or IRAK2. In addition; IL-1RAcP modulates the response to interleukins by associating with soluble IL1R1 and enhancing interleukin-binding to the decoy receptor.

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