Recombinant Human IL-23 P19 Protein(His Tag)

    • Recombinant Human IL-23 P19 Protein(His Tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
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    • Recombinant Human IL-23 P19 Protein(His Tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
    • Recombinant Human IL-23 P19 Protein(His Tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience

      Catalog number:PKSH030445

      Synonyms:IL-23;IL-23A;IL23P19;P19;SGRF

      Size:
      • 5µg
      • 10µg
      Qty:
      - +
      Price: $127

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms IL-23;IL-23A;IL23P19;P19;SGRF
      Species Human
      Expression_host HEK293 Cells
      Sequence Met 1-Pro 189&Met 1-Ser 328
      Accession Q9NPF7&NP_002178.2
      Mol_Mass 56.3 (20.1 + 36.2) kDa
      AP_Mol_Mass 22&45 kDa
      Tag C-His
      Bio_Activity 1. Measured by its ability to bind biotinylated recombinant human IL12RB1 in a functional ELISA.2. Measured by its binding ability in a functional ELISA. Immobilized human IL23A-His+IL12B-His at 10 μg/ml (100 μl/well) can bind human IL23R-Fc. The EC50 of human IL23R-Fc is 0.28-0.66 μg/ml.3. Measured by its binding ability in a functional ELISA. Immobilized human IL23A-His+IL12B-His at 10 μg/ml (100 μl/well) can bind Cynomolgus IL23R-Fc. The EC50 of Cynomolgus IL23R-Fc is 0.14-0.35 μg/ml.4. Measured by its ability to induce IL17 secretion by mouse splenocytes. The ED50 for this effect is 4-20 ng/mL.

      Properties

      Purity > 90 % as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per µg as determined by the LAL method.
      Storage Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from sterile PBS, pH 7.4
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Interleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12. The p19 subunit has homology to the p35 subunit of IL-12, as well as to other single chain cytokines such as IL-6 and IL-11. The p40 subunit is homologous to the extracellular domains of the hematopoietic cytokine receptors. Although p19 is expressed by activated macrophages, dendritic cells, T cells, and endothelial cells, only activated macrophages and dendritic cells express p40 concurrently to produce IL-23. IL-23 has biological activities that are similar to, but distinct from IL-12. Both IL-12 and IL-23 induce proliferation and IFN-gamma production by human T cells. While IL-12 acts on both naive and memory human T cells, the effects of IL-23 is restricted to memory T cells.

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