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Recombinant Human LIFR/CD118 Protein (His Tag)

Cat:PKSH031500
Manual MSDS

Price: $ 732

Size:
100μg
Quantity:
  • Expression Host: HEK293 Cells
  • Accession: NP_001121143.1
  • Applications: ELISA
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Product Details
Synonyms CD118;LIF-R;SJS2;STWS;SWS
Species Human
Expression Host HEK293 Cells
Sequence Met 1-Ser 833
Accession NP_001121143.1
Calculated Molecular Weight 91.0 kDa
Observed Molecular Weight 125-135 kDa
Tag C-His
Bio-activity Immobilized LIF Protein, Human, Recombinant (hFc Tag) at 2 ug/mL (100 μL/well) can bind LIFR Protein,Human,Recombinant (His Tag), the EC50 is 60-360 ng/mL.
Purity > 90 % as determined by reducing SDS-PAGE.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution Please refer to the printed manual for detailed information.
Background LIFR (leukemia inhibitory factor receptor) belongs to the family of cytokine receptors. LIFR forms a high-affinity receptor complex with gp130, which mediates the activity of LIF (leukemia inhibitory factor) and thus affects the differentiation, proliferation, and survival of a wide variety of cells in the adult and the embryo. Besides LIF, LIFR can also bind to and activate CNTF (ciliary neurotrophic factor) and CLC (cardiotrophin like cytokine). Evidence showed that in the retina, LIFR activating LIF, CT-1 and cardiotrophin like cytokine (CLC) are strongly upregulated in response to preconditioning with bright cyclic light leading to robust activation of signal transducer and activator of transcription-3 (STAT3) in a time-dependent manner. Further, blocking LIFR activation during preconditioning using a LIFR antagonist (LIF05) attenuated the induced STAT3 activation and also resulted in reduced preconditioning-induced protection of the retinal photoreceptors. These data demonstrate that LIFR and its ligands play an essential role in endogenous neuroprotective mechanisms triggered by preconditioning-induced stress. LIFR was newly found to be a suppressor of hepatocellular carcinoma (HCC), one of the world's top five causes of cancer-related deaths.