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Recombinant Human NGAL/LCN2 Protein (His Tag)

  • Cat.No.:PKSH033839

  • Expression host: E.coli

To Purchase PKSH033839

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  • 100µg
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Description

Synonyms 24p3; 25 kDa Alpha 2 Microglobulin Related Subunit of MMP9; Alpha 2 Microglobulin Related Protein;HGNC:6526; Lcn 2; Lipocalin-2; Migration Stimulating Factor Inhibitor; MSFI; Oncogene 24p3; p25; Siderocalin; Siderocalin LCN2;SV40 induced 24P3 Protein;Uterocalin;Neutrophil Gelatinase Associated Lipocalin
Species Human
Expression_host E.coli
Sequence Gln21-Gly198
Accession P80188-1
Application Immunogen, Positive Control
Mol_Mass 20.5kDa
AP_Mol_Mass 19kDa
Tag N-His

Properties

Purity >95 % as determined by reducing SDS-PAGE.
Endotoxin level Not tested.
Storage Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from sterile PBS, pH 7.4
Reconstitution Please refer to the printed manual for detailed information.

Background

Lipocalin-2 (LCN2), also known as neutrophil gelatinase-associated lipocalin (NGAL), is a 25 kDa protein belonging to the lipocalin superfamily. It was initially found in activated neutrophils, however, many other cells, like kidney tubular cells, may produce NGAL in response to various insults. This protein is released from injured tubular cells after various damaging stimuli, is already known by nephrologists as one of the most promising biomarkers of incoming Acute Kidney Injury (AKI). Recent evidence also suggests its role as a biomarker in a variety of other renal and non-renal conditions. Moreover, recent studies seem to suggest a potential involvement of this factor also in the genesis and progression of chronic kidney diseases. NGAL is the first known mammalian protein which specifically binds organic molecules called siderophores, which are high-affinity iron chelators. NGAL, first known as an antibacterial factor of natural immunity, and an acute phase protein, is currently one of the most interesting and enigmatic proteins involved in the process of tumor development. acting as an intracellular iron carrier and protecting MMP9 from proteolytic degradation, NGAL has a clear pro-tumoral effect, as has already been observed in different tumors (e.g. breast, stomach, oesophagus, brain) in humans. In thyroid carcinomas, NGAL is strongly induced by NF-kB, an important factor involved both in tumor growth and in the link between chronic inflammation and neoplastic development. Thus, Lipocalin-2 (LCN2/NGAL) has been implicated in a variety of processes including cell differentiation, proliferation, survival and morphogenesis.

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