Recombinant Human Oncostatin M/OSM Protein (His Tag)(Active)

    • Recombinant Human Oncostatin M / OSM Protein (N-His)-Elabscience
    • Recombinant Protein-Elabscience
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    • Recombinant Human Oncostatin M / OSM Protein (N-His)-Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Human Oncostatin M / OSM Protein (N-His)-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSH033574

      Synonyms:Oncostatin-M; OSM

      Size:
      • 10μg
      • 50μg
      Qty:
      - +
      Price: $178

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      Overview

      Synonyms Oncostatin-M; OSM
      Species Human
      Expression_host E.coli
      Sequence Ala26-Arg221
      Accession P13725
      Application Cell Culture
      Mol_Mass 24.44 kDa
      AP_Mol_Mass 28 kDa
      Tag N-His
      Bio_Activity Measured by the dose-dependent stimulation of TF-1 cells. The ED50 for this effect is 0.2-1ng/ml.

      Properties

      Purity > 95% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Oncostatin M (OSM) is a glycoprotein belonging to the interleukin-6 family of cytokines that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. OSM encodes a growth regulator, which Inhibits the proliferation of a number of tumor cell lines. It stimulates proliferation of AIDS-KS cells. OSM regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. OSM is considered as a pleiotropic cytokine that initiates its biological activities through specific cell surface receptors. The low affinity LIF receptor that shares the similarity of containing protein gp130 has now been identified to be a component of a high- affinity OSM receptor that will transduce OSM signals. OSM has also been shown to play a role in both pro and anti-inflammatory actions. OSM may also be involved in many biometabolism processes including liver development, haematopoeisis, inflammation, bone formation and destruction and possibly CNS development.

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