Recombinant Human PBEF/NAMPT Protein (His Tag)

    • Recombinant Human PBEF / Visfatin / NAMPT Protein (N-His)-Elabscience
    • Recombinant Protein-Elabscience
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    • Recombinant Human PBEF / Visfatin / NAMPT Protein (N-His)-Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Human PBEF / Visfatin / NAMPT Protein (N-His)-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSH033560

      Synonyms:Pre-B cell-enhancing factor; Nicotinamide phosphoribosyltransferase; NAmPRTase; Nampt; Pre-B-cell colony-enhancing factor 1; Visfatin; NAMPT; PBEF; PBEF1

      Size:
      • 10μg
      • 50μg
      Qty:
      - +
      Price: $117

      Lead Time: Order now, ship in 3 daysWelcome to order from local distributors.

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      Overview

      Synonyms Pre-B cell-enhancing factor; Nicotinamide phosphoribosyltransferase; NAmPRTase; Nampt; Pre-B-cell colony-enhancing factor 1; Visfatin; NAMPT; PBEF; PBEF1
      Species Human
      Expression_host E.coli
      Sequence Met1-His491
      Accession P43490
      Mol_Mass 57 kDa
      AP_Mol_Mass 55 kDa
      Tag N-His

      Properties

      Purity > 90% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from a 0.2 μm filtered solution of 20mM HEPES, 150mM NaCl, pH8.0.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Pre-B cell colony enhancing factor (PBEF) was originally identified as a cytokine that potentiated the clonal expansion and differentiation of pre-B cells, but it is also acknowledged to be the ubiquitous intracellular enzyme nicotinamide phosphoribosyltranferase (NAMPT) and the adipokine “visfatin”. PBEF is constitutively expressed in the fetal membranes where its greatest expression is in the amnion. It has intracellular and extracellular forms. Most of the intracellular functions of PBEF are due to its role as a Nampt which can induce angiogenesis through upregulation of VEGF and VEGFR and secretion of MCP-1. Extracellular PBEF has been shown to increase inflammatory cytokines, such as TNF-α, IL-1β, IL-16, and TGF-β1. PBEF also increases the production of IL-6, TNF-α, and IL-1β in CD14+ monocyctes, macrophages, and dendritic cells, enhances the effectiveness of T cells.

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