Recombinant Human SIGLEC15/CD33L3 Protein (His Tag)(Active)

    • Recombinant Human SIGLEC15 / CD33L3 Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience
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    • Recombinant Human SIGLEC15 / CD33L3 Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Human SIGLEC15 / CD33L3 Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSH033529

      Synonyms:Sialic acid-binding Ig-like lectin 15; Siglec-15; CD33 antigen-like 3; CD33L3

      Size:
      • 10μg
      • 50μg
      Qty:
      - +
      Price: $129

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      Overview

      Synonyms Sialic acid-binding Ig-like lectin 15; Siglec-15; CD33 antigen-like 3; CD33L3
      Species Human
      Expression_host Human Cells
      Sequence Phe20-Thr263
      Accession Q6ZMC9
      Application Functional ELISA
      Mol_Mass 27.4 kDa
      AP_Mol_Mass 30-40 kDa
      Tag C-His
      Bio_Activity Immobilized Human Siglec-15-His at 10μg/ml(100 μl/well) can bind Biotinylated Human MAG-His(Cat: PKSM041303). The ED50 of Human Siglec-15-His is 6.2ug/ml .

      Properties

      Purity > 95% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from a 0.2 μm filtered solution of PBS,150mMNacl,0.3%chaps,5% Trehalose,pH 7.4.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Human Siglec-15 is a transmembrane glycoprotein in the Siglec family. Siglecs are type I transmembrane proteins where the NH3+-terminus is in the extracellular space and the COO?-terminus is cytosolic. Each Siglec contains an N-terminal V-type immunoglobulin domain (Ig domain) which acts as the binding receptor for sialic acid. These lectins are placed into the group of I-type lectins because the lectin domain is an immunoglobulin fold. All Siglecs are extended from the cell surface by C2-type Ig domains which have no binding activity. Siglecs differ in the number of these C2-type domains. Human Siglec-15 consists of a 244 amino acid (aa) extracellular domain (ECD) with two Ig-like domains, a 21 aa transmembrane segment, and a 44 aa cytoplasmic domain. Siglec-15 function is important for osteoclast formation and TRANCE/RANK Ligand signaling in osteoclasts.

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      MSDS for ELISA ISO 9001

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