Recombinant Human SMPD1 / ASM Protein (His tag)

    • Recombinant Human SMPD1 / ASM Protein (His tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
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    • Recombinant Human SMPD1 / ASM Protein (His tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
    • Recombinant Human SMPD1 / ASM Protein (His tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience

      Catalog number:PKSH030372

      Synonyms:ASM;ASMASE;NPD

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      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms ASM;ASMASE;NPD
      Species Human
      Expression_host Baculovirus-Insect Cells
      Sequence Met 1-Cys 631
      Accession NP_000534.3
      Mol_Mass 65 kDa
      AP_Mol_Mass 65 kDa
      Tag C-His
      Bio_Activity Measured by its ability to cleave. 2-N-Hexadecanoylamino-4-nitrophenylphosphorylcholine (HNPPC). The specific activity is >1,000 pmol/min/μg.

      Properties

      Purity > 94 % as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per µg as determined by the LAL method.
      Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt, store it immediately at<-20°C.
      Formulation Lyophilized from sterile 50mM Tris, 100mM NaCl, pH 8.0, 0.1% OGP, 10% glycerol
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Sphingomyelin phosphodiesterase 1 (SMPD1) , also known as ASM ( acid sphingomyelinase ), is a member of the acid sphingomyelinase family of enzymes. Three isoforms have been identified, isoform 1 is 631 amino acids (aa) in length as the pro form, while Isoform 2 and isoform 3 have lost catalytic activity. The active SMPD1 isoform 1 contains one saposin B-type domain that likely interacts with sphingomyelin, and a catalytic region. Human SMPD1 is 86% aa identical to mouse SMPD1. SMPD1 is a monomeric lysosomal enzyme that converts sphingomyelin (a plasma membrane lipid ) into ceramide through the removal of phosphorylcholine. This generates second messenger components that participate in signal transduction. Defects in SMPD1 are the cause of Niemann-Pick disease type A (NPA) and type B (NPB), also known as Niemann-Pick disease classical infantile form and Niemann-Pick disease visceral form. Niemann-Pick disease is a clinically and genetically heterogeneous recessive disorder. NPB has little if any neurologic involvement and patients may survive into adulthood.

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