Recombinant Human SPHK1 / Sphingosine Kinase 1 Protein

    • Recombinant Human SPHK1 / Sphingosine Kinase 1 Protein-Elabscience
    • Recombinant protein products for various applications-Elabscience
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    • Recombinant Human SPHK1 / Sphingosine Kinase 1 Protein-Elabscience
    • Recombinant protein products for various applications-Elabscience
    • Recombinant Human SPHK1 / Sphingosine Kinase 1 Protein-Elabscience
    • Recombinant protein products for various applications-Elabscience

      Catalog number:PKSH030315

      Synonyms:SPHK;SPHK1;SPK

      Size:
      • 20µg
      • 50µg
      Qty:
      - +
      Price: $486

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms SPHK;SPHK1;SPK
      Species Human
      Expression_host Baculovirus-Insect Cells
      Sequence Met 1-Leu 384
      Accession Q9NYA1-1
      Mol_Mass 42.7 kDa
      AP_Mol_Mass 46 kDa
      Bio_Activity The specific activity was determined to be 1028 nmol/min/mg using Sphingosine Kinase Substrate as substrate.

      Properties

      Purity > 85 % as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per µg as determined by the LAL method.
      Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
      Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt, store it immediately at<-20°C.
      Formulation Supplied as sterile 20mM Tris, 500mM NaCl, 10% glycerol, pH 8.0
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      SPHK1, also known as sphingosine Kinase 1, catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P). S1P exhibits a broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis. It is a ligand for cell surface G protein-coupled receptors. SPHK 1 is a potential therapeutic target for the control of cancer and inflammation. SPHK1 plays a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes.

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