Recombinant Human TLK2 / PKU-ALPHA Protein (aa 397-772)

    • Recombinant Human TLK2 / PKU-ALPHA Protein (aa 397-772)-Elabscience
    • Recombinant protein products for various applications-Elabscience
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    • Recombinant Human TLK2 / PKU-ALPHA Protein (aa 397-772)-Elabscience
    • Recombinant protein products for various applications-Elabscience
    • Recombinant Human TLK2 / PKU-ALPHA Protein (aa 397-772)-Elabscience
    • Recombinant protein products for various applications-Elabscience

      Catalog number:PKSH030362

      Synonyms:HsHPK;PKU-ALPHA

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      Overview

      Synonyms HsHPK;PKU-ALPHA
      Species Human
      Expression_host Baculovirus-Insect Cells
      Sequence Leu 397-Asn772
      Accession Q86UE8-1
      Mol_Mass 43.6 kDa
      AP_Mol_Mass 44 kDa

      Properties

      Purity > 95 % as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per µg as determined by the LAL method.
      Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt, store it immediately at<-20°C.
      Formulation Supplied as sterile 20mM Tris, 500mM NaCl, 3mM DTT, 10% glycerol, pH 8.0
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Serine / threonine-protein kinase tousled-like 2, also known as PKU-alpha, Tousled-like kinase 2 and TLK2, is a nucleus protein which belongs to the protein kinase superfamily and Ser/Thr protein kinase family. The tousled-like kinases are an evolutionarily conserved family of proteins implicated in DNA repair, DNA replication and mitosis in metazoans and plants. Their absence from the yeasts and other eukaryotic 'microbes' suggests a specific role for them in the development of multicellular organisms. Tousled-like kinase 2 / TLK2 is widely expressed. It is present in fetal placenta, liver, kidney, pancreas, heart and skeletal muscle. It is also found in adult cell lines. Tousled-like kinase 2 / TLK2 contains one protein kinase domain. Tousled-like kinase 2 / TLK2 is rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly.

      SDS-PAGE

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      MSDS for ELISA

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