Recombinant Human VEGFR2/Flk-1/KDR Protein (His Tag)

    • Recombinant Human VEGFR2 / KDR Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience
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    • Recombinant Human VEGFR2 / KDR Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Human VEGFR2 / KDR Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSH033473

      Synonyms:Vascular endothelial growth factor receptor 2; KDR; VEGFR-2; Fetal liver kinase 1; FLK-1; Kinase insert domain receptor; Protein-tyrosine kinase receptor flk-1;CD309;Flk-1;FLK1;VEGFR;VEGFR2

      Size:
      • 10μg
      • 50μg
      Qty:
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      Price: $178

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      Overview

      Synonyms Vascular endothelial growth factor receptor 2; KDR; VEGFR-2; Fetal liver kinase 1; FLK-1; Kinase insert domain receptor; Protein-tyrosine kinase receptor flk-1;CD309;Flk-1;FLK1;VEGFR;VEGFR2
      Species Human
      Expression_host Human Cells
      Sequence Ala20-Glu764
      Accession P35968
      Mol_Mass 84.3 kDa
      AP_Mol_Mass 84-95 kDa
      Tag C-His

      Properties

      Purity > 95% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from a 0.2 μm filtered solution of PBS,pH 7.4.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Human Vascular endothelial growth factor receptor 2(KDR, VEGFR-2) is a member of the class III subfamily of receptor tyrosine kinases (RTKs). KDR is involved in a number of fundamental biological processes such as the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. It also plays an essential role in promoting proliferation, survival, migration and differentiation of endothelial cells, reorganization of the actin cytoskeleton. VEGFR2 is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo.The adaptor protein SHB has been shown to interact with VEGFR2 in receptor tyrosine kinase signaling. In addition, VEGFR2 is able to interact with HIV-1 extracellular Tat protein upon VEGF activation, and seems to enhance angiogenesis in Kaposi's sarcoma lesions. VEGF R2 is thought to be the primary inducer of VEGF-mediated blood vessel growth, while VEGF R3 plays a significant role in VEGF-C and VEGF-D-mediated lymphangiogenesis.

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