Recombinant Mouse ACP5/TRAP Protein (His Tag)(Active)

    • Recombinant Mouse ACP5 / TRAP Protein (His tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
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    • Recombinant Mouse ACP5 / TRAP Protein (His tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
    • Recombinant Mouse ACP5 / TRAP Protein (His tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience

      Catalog number:PKSM040765

      Synonyms:TRACP;TRAP

      Size:
      • 10 μg
      • 20 μg
      Qty:
      - +
      Price: $365

      Lead Time: 7~10 daysWelcome to order from local distributors.

      Add to cart Compare Bulk request Manual

      Overview

      Synonyms TRACP;TRAP
      Species Mouse
      Expression_host HEK293 Cells
      Sequence Met 1-Pro 327
      Accession NP_031414.1
      Mol_Mass 35.8 kDa
      AP_Mol_Mass 35.8 kDa
      Tag C-His
      Bio_Activity Measured by its ability to cleave a substrate, p-Nitrophenyl phosphate (pNPP). The specific activity is >9,000 pmoles/min/µg.

      Properties

      Purity > 95 % as determined by SDS-PAGE
      Endotoxin < 1.0 EU per µg of the protein as determined by the LAL method.
      Storage Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from sterile PBS, pH 7.4
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Tartrate-resistant acid phosphatase (TRACP) or acid phosphatase 5, tartrate resistant (ACP5 or TRAP) is a glycosylated monomeric metalloenzyme expressed in mammals. TRACP is associated with osteoblast migration to bone resorption sites, and, once there, TRACP is believed to initiate osteoblast differentiation, activation, and proliferation. TRACP once considered to be just a histochemical marker of osteoclasts is now recognised to be a molecule of widespread occurrence with functions in both the skeleton and the immune system. Two forms of TRACP circulate in human blood, TRACP 5a derived from macrophages and dendritic cells, and TRACP-5b derived from osteoclasts. Recent data have demonstrated the utility of TRACP-5b as a marker of osteoclast number and bone resorption, and serum TRACP-5a as a marker of inflammatory conditions. TRACP is expressed by osteoclasts, macrophages, dendritic cells and a number of other cell types. It has a critical role in many biological processes including skeletal development, collagen synthesis and degradation, the mineralisation of bone, cytokine production by macrophages and dendritic cells, macrophage recruitment, dendritic cell maturation and a role in the development of Th1 responses.

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