Recombinant Mouse ALCAM/CD166 Protein (His Tag) (Active)

    • Recombinant Mouse  CD166 / ALCAM Protein (His Tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
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    • Recombinant Mouse  CD166 / ALCAM Protein (His Tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
    • Recombinant Mouse  CD166 / ALCAM Protein (His Tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience

      Catalog number:PKSM040923

      Synonyms:AI853494; BEN; CD166; DM-GRASP; MuSC; SC1;CD166 antigen;cluster of differentiation 166; CD166; activated leucocyte cell adhesion molecule; CD6 ligand; Protein DM-GRASP;CD6L;MEMD

      Size:
      • 50 μg
      • 100 μg
      Qty:
      - +
      Price: $454

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms AI853494; BEN; CD166; DM-GRASP; MuSC; SC1;CD166 antigen;cluster of differentiation 166; CD166; activated leucocyte cell adhesion molecule; CD6 ligand; Protein DM-GRASP;CD6L;MEMD
      Species Mouse
      Expression_host HEK293 Cells
      Sequence Met 1-Lys 527
      Accession NP_033785.1
      Application Functional ELISA
      Mol_Mass 57.7 kDa
      AP_Mol_Mass 70-80 kDa
      Tag C-His
      Bio_Activity Immobilized mouse ALCAM-His at 10 µg/ml (100 μl/well) can bind mouse CD6-Fc, The EC50 of mouse CD6-Fc is 0.08-0.18 µg/ml.

      Properties

      Purity > 98 % as determined by SDS-PAGE
      Endotoxin < 1.0 EU per µg of the protein as determined by the LAL method.
      Storage Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from sterile PBS, pH 7.4
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Activated leukocyte cell adhesion molecule (ALCAM)/Cluster of differentiation (CD166) is a type I transmembrane cell adhesion molecule belonging to the Ig superfamily and a ligand for CD6 that is expressed on T lymphocytes. The extracellular domain of ALCAM contains five Ig-like domains (three Ig-like C2-type domains and two Ig-like V-type domains), of which the amino-terminal V1 domain is essential for ligand binding and ALCAM-mediated cell aggregation. ALCAM mediates both heterophilic (ALCAM-CD6) and homophilic (ALCAM-ALCAM) cell-cell interactions. ALCAM/CD6 interaction plays a role in T cell development and T cell regulation, as well as in the binding of T- and B-cells to activated leukocytes. Recently, homophilic (ALCAM-ALCAM) adhesion was shown to play important roles in tight cell-to-cell interaction and regulation of stem cell differentiation. While expressed in a wide variety of tissues, ALCAM is usually restricted to subsets of cells involved in dynamic growth and/or migration, including neural development, branching organ development, hematopoiesis, immune response and tumor progression. And CD166 is regarded as a potential novel breast cancer indicator and therapeutic target.

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      MSDS for ELISA ISO 9001

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