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Recombinant Mouse Carboxylesterase-2/CES2 Protein (His Tag)

Uniprot : Q91WG0

Cat.No.:PKSM040639
Expression host: HEK293 Cells

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50μg

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Description

Synonyms	ces2A3
Species	Mouse
Expression_host	HEK293 Cells
Sequence	Met 1-Lys 557
Accession	NP_663578.1
Mol_Mass	60.4 kDa
AP_Mol_Mass	52 kDa
Tag	C-His
Bio_Activity	Measured by its ability to hydrolyze pnitrophenylacetate. The specific activity is > 90, 000 pmoles/min/μg.

Properties

Purity	> 85 % as determined by reducing SDS-PAGE.
Endotoxin level	< 1.0 EU per μg of the protein as determined by the LAL method.
Storage	Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Formulation	Lyophilized from sterile PBS, pH 7.4 Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual.
Reconstitution	Please refer to the printed manual for detailed information.

Background

Carboxylesterase 2 (CES2) is a member of the carboxylesterase family and belongs to the multigene family. Carboxylesterase 2 is responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and beroin. It also serves to hydrolyze long-chain fatty acid esters and thioesters. It is speculated that carboxylesterases may play a role in lipid metabolism and the blood-brain barrier system and together with isform 1, are a serine esterase involved in both drug metabolism and activation. Human carboxylesterase 2 is commonly expressed in tumor tissues and irinotecan, a topoisomerase I inhibitor commonly used in the treatment of many solid tumors.

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