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Recombinant Mouse CD27/TNFRSF7 Protein (His Tag)(Active)

  • Cat.No.:PKSM040859

  • Expression host: HEK293 Cells

To Purchase PKSM040859

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  • 50μg
  • 100μg
Price: $454
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Description

Synonyms CD27 antigen; CD27L receptor; T-cell activation antigen CD27; Tumor necrosis factor receptor superfamily member 7;S152;Tnfrsf7;Tp55
Species Mouse
Expression_host HEK293 Cells
Sequence Met 1-Arg 182
Accession NP_001028298.1
Application Functional ELISA
Mol_Mass 19.6 kDa
AP_Mol_Mass 35 kDa
Tag C-His
Bio_Activity Measured by its binding ability in a functional ELISA. Immobilized recombinant mouse CD27 at 2 µg/ml (100 μl/well) can bind human CD70 with a linear range of 78-1250 pg/ml.

Properties

Purity > 96 % as determined by SDS-PAGE
Endotoxin level < 1.0 EU per µg of the protein as determined by the LAL method.
Storage Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from sterile PBS, pH 7.4
Reconstitution Please refer to the printed manual for detailed information.

Background

CD27, also known as TNFRSF7, is a member of the TNF-receptor superfamily limited to cells of the lymphoid lineage, and exists as both a dimeric glycoprotein on the cell surface and as a soluble protein in serum. As a type I transmembrane glycoprotein of about 55 kDa existing as disulfide-linked homodimer, CD27 has been shown to play roles in lymphoid proliferation, differentiation, and apoptosis.It has important role in generation of T cell immunity, and is an apparently robust marker for normal memory B cells. It is a T and B cell co-stimulatory molecule, the activity of CD27 is governed by its TNF-like ligand CD70 on lymphocytes and dendritic cells. The CD27-CD70 interaction is required for Th1 generation responses to differentiation signals and long-term maintenance of T cell immunity, and meanwhile, plays a key role in regulating B-cell differentiation, activation and immunoglobulin synthesis.

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