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Recombinant Mouse CD40/TNFRSF5 Protein (His & Fc Tag)(Active)

  • Cat.No.:PKSM040734

  • Expression host: HEK293 Cells

To Purchase PKSM040734

Size:
  • 50μg
  • 100μg
Price: $454
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Description

Synonyms Tumor necrosis factor receptor superfamily member 5; B-cell surface antigen CD40; Bp50; CD40L receptor; CD40; TNFRSF5;I326936;HIGM1; IGM; IMD3; p50; T-BAM; Tnfrsf5; TRAP
Species Mouse
Expression_host HEK293 Cells
Sequence Met 1-Arg 193
Accession P27512-1
Application Functional ELISA
Mol_Mass 47 kDa
AP_Mol_Mass 57 kDa
Tag C-His-Fc
Bio_Activity Measured by its ability to bind recombinant human CD40L in a functional ELISA.

Properties

Purity > 90 % as determined by SDS-PAGE
Endotoxin level < 1.0 EU per µg of the protein as determined by the LAL method.
Storage Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from sterile PBS, pH 7.4
Reconstitution Please refer to the printed manual for detailed information.

Background

CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 protein is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines. Defects in CD40 result in hyper-IgM immunodeficiency type 3 (HIGM3). In addition, CD40/CD40L interaction is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis.

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